Click here to switch to the map view.

The map label for this gene is tcrA

Identifier: 148660372

GI number: 148660372

Start: 700348

End: 701109

Strand: Reverse

Name: tcrA

Synonym: MRA_0609

Alternate gene names: 148660372

Gene position: 701109-700348 (Counterclockwise)

Preceding gene: 148660382

Following gene: 148660371

Centisome position: 15.86

GC content: 69.16

Gene sequence:

>762_bases
GTGGCAGATGAAACGACGATGAGAGCTGGTCGCGGCCCGGGCCGGGCATGCGGCAGGGTGTCGGGTGTGCGCATCCTGGT
GGTCGAGGACGAGCCCAAGATGACGGCGCTGCTGGCGCGGGCGCTGACCGAGGAGGGCCACACGGTCGACACCGTTGCCG
ACGGCCGCCATGCGGTGGCGGCCGTCGACGGCGGTGACTACGACGCGGTGGTGCTGGATGTGATGCTGCCCGGTATCGAC
GGGTTCGAGGTATGCGCGCGGCTGCGACGGCAGCGGGTGTGGACACCGGTGCTGATGCTTACCGCCCGCGGCGCGGTCAC
CGACCGCATCGCGGGCCTAGACGGCGGCGCCGACGATTACCTCACCAAACCGTTCAACCTCGACGAACTGTTCGCCCGGT
TGCGCGCGCTGTCACGGCGCGGGCCCATCCCACGCCCACCGACGCTGGAGGCCGGCGATCTACGCCTGGACCCGAGCGAA
CACCGAGTCTGGCGTGCCGACACCGAAATCCGGCTCAGTCACAAGGAATTCACCCTGCTGGAAGCCCTGATCCGCCGTCC
CGGCATCGTCCACACCCGCGCCCAGCTGCTGGAACGCTGCTGGGACGCCGCCTACGAGGCCCGCTCCAACATCGTCGACG
TCTACATCCGCTACCTGCGCGACAAGATCGACCGGCCCTTCGGCGTCACCTCGCTGGAAACCATTCGCGGTGCCGGATAC
CGGCTGCGCAAGGACGGAGGACGGCATGCGCTCCCCCGCTGA

Upstream 100 bases:

>100_bases
GCCGCGGCCACGGCGGAAACTCCGAACTGCACGATGCGATTCATCGCTTTCTCCTGATCTGTCTACCTCGCTGTGACGGT
GTGCGGCTCCGACGGTAGGG

Downstream 100 bases:

>100_bases
GTGGCCCATCCGATGGCGACTCACCCTCGTCTTCAGCGCCGCCATGGCGCTCGTTCTGGCAGCAGCCGGCGCCGTCACCG
TCGTCCAGTTCCGCGACGCC

Product: putative two component DNA binding transcriptional regulatory protein TcrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGID
GFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSE
HRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
RLRKDGGRHALPR

Sequences:

>Translated_253_residues
MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGID
GFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSE
HRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
RLRKDGGRHALPR
>Mature_252_residues
ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDG
FEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEH
RVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYR
LRKDGGRHALPR

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=39.647577092511, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=41.3636363636364, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=40.9090909090909, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=37.3390557939914, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=37.8378378378378, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.0909090909091, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.7713004484305, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=33.4862385321101, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=34.061135371179, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=37.1681415929204, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=33.9130434782609, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=31.6017316017316, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.3030303030303, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=117, Percent_Identity=36.7521367521368, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=127, Percent_Identity=29.1338582677165, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=31.0924369747899, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=116, Percent_Identity=32.7586206896552, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=123, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TCRA1_MYCTU (O07776)

Other databases:

- EMBL:   BX842574
- PIR:   E70909
- RefSeq:   NP_215116.1
- HSSP:   Q9WYN0
- ProteinModelPortal:   O07776
- SMR:   O07776
- EnsemblBacteria:   EBMYCT00000002096
- GeneID:   887870
- GenomeReviews:   AL123456_GR
- KEGG:   mtu:Rv0602c
- TubercuList:   Rv0602c
- GeneTree:   EBGT00050000014820
- HOGENOM:   HBG753323
- ProtClustDB:   CLSK790622
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 28171; Mature: 28039

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEEE
AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
EECCCCCHHEEEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCCCCHHH
LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEECCCEEEECHHHHHHH
EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCE
RLRKDGGRHALPR
EEECCCCCCCCCC
>Mature Secondary Structure 
ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEEE
AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
EECCCCCHHEEEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCCCCHHH
LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEECCCEEEECHHHHHHH
EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCE
RLRKDGGRHALPR
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230