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The map label for this gene is menC

Identifier: 148660322

GI number: 148660322

Start: 645800

End: 646780

Strand: Direct

Name: menC

Synonym: MRA_0560

Alternate gene names: 148660322

Gene position: 645800-646780 (Clockwise)

Preceding gene: 148660321

Following gene: 148660323

Centisome position: 14.61

GC content: 70.23

Gene sequence:

>981_bases
GTGATACCCGTGCTGCCCCCCCTAGAAGCCCTGCTGGACCGCCTGTATGTGGTGGCCCTGCCGATGCGAGTGCGTTTCCG
CGGCATCACCACCCGTGAAGTGGCCTTGATCGAGGGTCCGGCCGGTTGGGGCGAATTCGGTGCGTTCGTGGAGTACCAGT
CCGCGCAGGCGTGCGCGTGGTTGGCGTCGGCGATCGAGACCGCCTACTGTGCGCCGCCGCCGGTGCGACGTGACCGCGTT
CCGATTAACGCCACTGTGCCGGCCGTTGCCGCCGCCCAGGTGGGCGAGGTGCTGGCCCGGTTTCCTGGGGCCCGGACGGC
CAAGGTGAAGGTCGCCGAGCCTGGGCAGAGCTTGGCCGACGACATCGAGCGTGTCAACGCGGTTCGGGAGCTGGTTCCCA
TGGTGCGGGTGGACGCCAACGGTGGCTGGGGTGTCGCCGAGGCGGTGGCCGCGGCGGCCGCCCTGACCGCCGACGGCCCG
CTGGAATACCTTGAACAACCCTGTGCCACCGTCGCCGAACTCGCCGAGTTGCGCCGGCGGGTGGATGTGCCGATCGCCGC
CGACGAAAGCATCCGCAAGGCCGAGGATCCGTTGGCCGTTGTCCGCGCTCAGGCCGCCGATATCGCGGTGCTGAAGGTCG
CCCCGCTGGGCGGTATTTCGGCGCTGCTTGATATCGCGGCGCGGATCGCCGTTCCGGTGGTGGTCTCCAGCGCGCTCGAT
TCCGCCGTCGGAATCGCCGCCGGCCTGACCGCCGCCGCGGCCCTGCCGGAGCTCGACCACGCGTGCGGGCTGGGCACCGG
CGGGCTGTTTGAAGAGGACGTGGCCGAGCCCGCAGCACCCGTCGACGGCTTTCTGGCAGTTGCGCGGACAACGCCCGACC
CGGCGCGGTTGCAAGCCCTGGGTGCACCGCCGCAGCGGCGACAGTGGTGGATCGACCGGGTCAAGGCCTGCTACTCGTTG
CTTGTACCGTCTTTCGGGTGA

Upstream 100 bases:

>100_bases
TGGTGGTGCTGTCGGCGGATCCCCGGACGGTGCCGCCAGAGCAGATCGCCGACCTGGCGGTGCGGGCGACGTTTCTGGCC
GGTCGCCAGGTTTATCGGCG

Downstream 100 bases:

>100_bases
TCAACCTGGCCTACGACGACAACGGGACCGGTGACCCGGTGGTCTTTATCGCCGGCCGCGGCGGCGCCGGACGCACCTGG
CACCCACATCAAGTCCCGGC

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRV
PINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGP
LEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALD
SAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSL
LVPSFG

Sequences:

>Translated_326_residues
MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRV
PINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGP
LEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALD
SAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSL
LVPSFG
>Mature_326_residues
MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRV
PINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGP
LEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALD
SAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSL
LVPSFG

Specific function: Converts SHCHC to OSB

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENC_MYCBO (P65426)

Other databases:

- EMBL:   BX248335
- RefSeq:   NP_854228.1
- ProteinModelPortal:   P65426
- SMR:   P65426
- EnsemblBacteria:   EBMYCT00000016127
- GeneID:   1091649
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0568
- GeneTree:   EBGT00050000017426
- HOGENOM:   HBG568083
- OMA:   LEYVEQP
- ProtClustDB:   PRK02901
- BioCyc:   MBOV233413:MB0568-MONOMER
- BRENDA:   4.2.1.113
- HAMAP:   MF_00470
- InterPro:   IPR013342
- InterPro:   IPR001354
- InterPro:   IPR010196
- PANTHER:   PTHR13794
- SMART:   SM00922

Pfam domain/function: PF01188 MR_MLE

EC number: =4.2.1.113

Molecular weight: Translated: 33975; Mature: 33975

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: ACT_SITE 110-110 ACT_SITE 212-212

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAW
CCCCCCCHHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCCCHHHHHHHHHCCHHHHHH
LASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLAD
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
DIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAELRRR
HHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALD
CCCCCCCCHHHHHHCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQAL
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHCCCCCCCCHHEEEECCCCCHHHHHCC
GAPPQRRQWWIDRVKACYSLLVPSFG
CCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAW
CCCCCCCHHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCCCHHHHHHHHHCCHHHHHH
LASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLAD
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
DIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAELRRR
HHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALD
CCCCCCCCHHHHHHCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQAL
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHCCCCCCCCHHEEEECCCCCHHHHHCC
GAPPQRRQWWIDRVKACYSLLVPSFG
CCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972