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The map label for this gene is proC

Identifier: 148660268

GI number: 148660268

Start: 591393

End: 592280

Strand: Direct

Name: proC

Synonym: MRA_0507

Alternate gene names: 148660268

Gene position: 591393-592280 (Clockwise)

Preceding gene: 148660267

Following gene: 148660269

Centisome position: 13.38

GC content: 66.22

Gene sequence:

>888_bases
ATGCTTTTCGGCATGGCAAGGATCGCGATTATCGGCGGCGGCAGCATCGGTGAGGCATTGCTGTCGGGTCTGCTGCGGGC
GGGCCGGCAGGTCAAAGACCTGGTAGTGGCCGAGCGGATGCCCGATCGCGCCAACTACCTGGCGCAGACCTATTCGGTGT
TGGTGACGTCGGCGGCCGACGCGGTGGAGAACGCGACGTTCGTCGTCGTCGCGGTCAAACCAGCCGACGTCGAGCCGGTG
ATCGCGGATCTGGCGAACGCGACTGCGGCGGCCGAAAACGACAGTGCTGAGCAGGTGTTCGTCACCGTGGTAGCGGGCAT
CACGATCGCGTATTTCGAATCCAAGCTACCGGCTGGGACGCCAGTGGTGCGTGCGATGCCGAACGCGGCGGCATTGGTGG
GAGCGGGGGTTACAGCGCTGGCCAAAGGCCGCTTTGTCACCCCGCAACAGCTTGAGGAGGTCTCGGCCTTGTTCGACGCG
GTCGGCGGCGTGCTGACCGTTCCGGAATCGCAGTTGGACGCGGTGACCGCGGTGTCCGGCTCGGGTCCGGCCTATTTCTT
TCTGCTGGTCGAGGCCCTGGTGGATGCCGGAGTCGGGGTGGGCTTGAGCCGTCAGGTGGCCACCGATCTCGCCGCGCAGA
CAATGGCTGGCTCAGCGGCGATGCTGCTGGAGCGGATGGAGCAAGACCAGGGTGGCGCCAATGGCGAGCTGATGGGGCTG
CGCGTGGACCTTACCGCATCACGGCTGCGCGCCGCGGTTACCTCGCCGGGCGGTACGACCGCCGCTGCGCTGCGGGAACT
CGAACGCGGCGGGTTTCGGATGGCTGTCGACGCGGCGGTTCAAGCCGCCAAAAGCCGCTCTGAGCAGCTCAGAATTACAC
CGGAATGA

Upstream 100 bases:

>100_bases
GGACCACATCGTCGTCGACCGGTTGGGCCGCATCGTGGTGCAGACGCGCCAACTGGCGATGGTGCCTGCCCAGTAGCACG
GATCGGCCGAGCTGTCTGCG

Downstream 100 bases:

>100_bases
TTCACGAATTTTGAACTGATTATCCCTCACCAGTACCAGTAACCCCACTAGTCCCGCTATTCTCCTCTTTGTAAGCGCGT
GTGGGTGCCAGCGGAGGGGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPV
IADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGL
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE

Sequences:

>Translated_295_residues
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPV
IADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGL
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
>Mature_295_residues
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPV
IADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGL
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family

Homologues:

Organism=Homo sapiens, GI198041662, Length=285, Percent_Identity=31.5789473684211, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI21361454, Length=291, Percent_Identity=32.9896907216495, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI24797097, Length=294, Percent_Identity=34.3537414965986, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI24797095, Length=294, Percent_Identity=34.3537414965986, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786585, Length=286, Percent_Identity=34.2657342657343, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=284, Percent_Identity=35.2112676056338, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=294, Percent_Identity=30.2721088435374, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=310, Percent_Identity=27.0967741935484, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21358587, Length=291, Percent_Identity=36.426116838488, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24648116, Length=295, Percent_Identity=33.2203389830508, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24647700, Length=185, Percent_Identity=41.6216216216216, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): P5CR_MYCTU (Q11141)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   G70745
- RefSeq:   NP_215014.1
- RefSeq:   NP_334929.1
- ProteinModelPortal:   Q11141
- SMR:   Q11141
- EnsemblBacteria:   EBMYCT00000000256
- EnsemblBacteria:   EBMYCT00000070475
- GeneID:   887256
- GeneID:   923905
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0520
- KEGG:   mtu:Rv0500
- TIGR:   MT0520
- TubercuList:   Rv0500
- GeneTree:   EBGT00050000017740
- HOGENOM:   HBG726602
- OMA:   INSGRIT
- ProtClustDB:   PRK11880
- BRENDA:   1.5.1.2
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0040007
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11645
- PIRSF:   PIRSF000193
- TIGRFAMs:   TIGR00112

Pfam domain/function: PF03807 F420_oxidored; SSF48179 6DGDH_C_like

EC number: =1.5.1.2

Molecular weight: Translated: 30172; Mature: 30172

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAAD
CCCCEEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGT
HHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSG
CHHHHCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHEEEECC
SGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEE
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
EEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAAD
CCCCEEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGT
HHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSG
CHHHHCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHEEEECC
SGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEE
RVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
EEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036