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The map label for this gene is senX3

Identifier: 148660257

GI number: 148660257

Start: 580659

End: 581891

Strand: Direct

Name: senX3

Synonym: MRA_0497

Alternate gene names: 148660257

Gene position: 580659-581891 (Clockwise)

Preceding gene: 148660256

Following gene: 148660258

Centisome position: 13.14

GC content: 64.88

Gene sequence:

>1233_bases
GTGACTGTGTTCTCGGCGCTGTTGCTGGCCGGGGTTTTGTCCGCGCTGGCACTGGCCGTCGGTGGTGCTGTTGGAATGCG
GCTGACGTCGCGGGTCGTCGAACAGCGCCAACGGGTGGCCACGGAGTGGTCGGGAATCACGGTTTCGCAGATGTTGCAAT
GCATTGTCACGCTGATGCCGCTGGGCGCCGCGGTGGTGGACACCCATCGCGACGTTGTCTACCTCAACGAACGGGCCAAA
GAGCTAGGTCTGGTGCGCGACCGCCAGCTCGATGATCAGGCCTGGCGGGCCGCCCGGCAGGCGCTGGGTGGTGAAGACGT
CGAGTTCGACCTGTCGCCGCGCAAGCGGTCGGCCACGGGTCGATCCGGGCTATCAGTGCATGGGCATGCCCGGTTGCTGA
GCGAGGAAGACCGCCGGTTCGCCGTGGTGTTCGTGCACGACCAGTCGGATTATGCGCGGATGGAGGCGGCTAGGCGTGAC
TTCGTGGCCAACGTCAGTCACGAGCTCAAGACGCCCGTCGGTGCCATGGCTCTACTCGCCGAGGCGCTGCTGGCGTCGGC
CGACGACTCCGAAACCGTTCGGCGGTTCGCCGAGAAGGTGCTCATTGAGGCCAACCGGCTCGGTGACATGGTCGCCGAGT
TGATCGAGCTATCCCGGCTACAGGGCGCCGAGCGGCTACCCAATATGACCGACGTCGACGTCGATACGATTGTGTCGGAA
GCGATTTCACGCCATAAGGTGGCGGCCGACAACGCCGACATCGAAGTCCGCACCGACGCGCCCAGCAATCTGCGGGTGCT
GGGCGACCAAACTCTGCTGGTTACCGCACTGGCAAACCTGGTTTCCAATGCGATTGCCTATTCGCCGCGCGGGTCGCTGG
TGTCGATCAGCCGTCGCCGTCGCGGTGCCAACATCGAGATCGCCGTCACCGACCGGGGCATCGGCATCGCGCCGGAAGAC
CAGGAGCGGGTCTTCGAACGGTTCTTCCGGGGGGACAAGGCGCGCTCGCGTGCCACCGGAGGCAGCGGACTCGGGTTGGC
CATCGTCAAACACGTCGCGGCTAATCACGACGGCACCATCCGCGTGTGGAGCAAACCGGGAACCGGGTCAACGTTCACCT
TGGCTCTTCCGGCGTTGATCGAGGCCTATCACGACGACGAGCGACCCGAGCAGGCGCGAGAGCCCGAACTGCGGTCAAAC
AGGTCACAACGAGAGGAAGAGCTGAGCCGATGA

Upstream 100 bases:

>100_bases
TGTGAACGGTAACCGAACAGCTGTGGCGTAGTGTGTGACTTGTCCGATTTTGGCCTTGCCGCGCTAGGGCGACGTTCACC
GGATTTGTAGGATTTTCCTT

Downstream 100 bases:

>100_bases
CCTGCGCCGACGACGATGCAGAGCGTAGCGATGAGGTGGGGGCACCACCCGCTTGCGGGGGAGAGTGGCGCTGATGACCT
GCGCCGACGACGATGCAGAG

Product: putative two component sensor histidine kinase SenX3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAK
ELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRD
FVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSE
AISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPED
QERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSN
RSQREEELSR

Sequences:

>Translated_410_residues
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAK
ELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRD
FVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSE
AISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPED
QERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSN
RSQREEELSR
>Mature_409_residues
TVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKE
LGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDF
VANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEA
ISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQ
ERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNR
SQREEELSR

Specific function: Probably forms part of a two-component regulatory system senX3/regX3. Phosphorylates regX3 (Probable)

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=34.4262295081967, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=29.8642533936652, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=31.4159292035398, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=31.6964285714286, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=32.3404255319149, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=27.4193548387097, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=27.9661016949153, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693157, Length=394, Percent_Identity=25.6345177664975, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=27.6859504132231, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=29.6610169491525, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=27.6422764227642, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=200, Percent_Identity=30, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789403, Length=204, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=27.3469387755102, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=245, Percent_Identity=27.3469387755102, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=28.90625, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=27.6679841897233, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=217, Percent_Identity=29.4930875576037, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=101, Percent_Identity=44.5544554455446, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SENX3_MYCBO (P0A601)

Other databases:

- EMBL:   Y13627
- EMBL:   BX248335
- RefSeq:   NP_854163.1
- ProteinModelPortal:   P0A601
- EnsemblBacteria:   EBMYCT00000018095
- GeneID:   1091549
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0500
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG334875
- OMA:   PADGLRI
- ProtClustDB:   CLSK790553
- BioCyc:   MBOV233413:MB0500-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 44825; Mature: 44694

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1bd741e8)-; HASH(0x1c7a53c8)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATG
CCHHHHHCCCCEEEECHHHHHHCCHHCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCC
RSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLA
CCCCEECHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHH
AISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRR
HHHHHHHCCCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHC
RGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTI
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCCEE
RVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
EEEECCCCCCEEEHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATG
CCHHHHHCCCCEEEECHHHHHHCCHHCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCC
RSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLA
CCCCEECHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHH
AISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRR
HHHHHHHCCCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHC
RGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTI
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCCEE
RVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
EEEECCCCCCEEEHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9426136; 12788972