BacMap

Definition	Mycobacterium tuberculosis H37Ra, complete genome.
Accession	NC_009525
Length	4,419,977

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The map label for this gene is ydfG [C]

Identifier: 148660251

GI number: 148660251

Start: 574356

End: 575111

Strand: Reverse

Name: ydfG [C]

Synonym: MRA_0491

Alternate gene names: 148660251

Gene position: 575111-574356 (Counterclockwise)

Preceding gene: 148660259

Following gene: 148660248

Centisome position: 13.01

GC content: 68.12

Gene sequence:

>756_bases
ATGACGACAATCGGCACCCGCAAGCGAGTCGCCGTGGTCACCGGCGCCAGTTCCGGTATCGGCGAGGCAACCGCGAGAAC
CCTTGCGGCCCAGGGGTTTCACGTGGTCGCGGTGGCGCGTCGGGCGGACCGGATCACCGCGCTGGCCAACCAGATCGGCG
GAACCGCAATTGTGGCCGATGTCACTGACGACGCCGCCGTCGAAGCGTTGGCCCGCGCGCTGAGCCGGGTGGACGTGCTG
GTCAACAACGCCGGTGGCGCCAAGGGGCTTCAGTTCGTCGCCGATGCCGATTTGGAGCACTGGCGATGGATGTGGGACAC
CAACGTACTGGGCACGCTGCGGGTAACCCGCGCGCTGCTGCCCAAGCTGATCGACTCCGGCGACGGCCTGATCGTCACCG
TCACCTCGATCGCCGCGATCGAGGTGTACGACGGCGGCGCCGGCTACACCGCTGCCAAGCACGCGCAGGGCGCGCTGCAT
CGCACGCTGCGCGGCGAACTGCTGGGGAAGCCGGTCCGGCTCACCGAGATCGCTCCAGGTGCGGTCGAGACCGAATTTTC
GCTGGTCCGCTTCGACGGCGACCAGCAACGCGCGGACGCGGTTTATGCCGGCATGACACCGCTAGTAGCCGCCGACGTCG
CCGAGGTGATCGGATTCGTGGCCACCCGGCCCTCACACGTCAACCTTGACCAGATCGTCATCCGGCCCCGCGACCAGGCA
TCAGCTAGCCGTCGCGCTACCCACCCGGTCCGTTAG

Upstream 100 bases:

>100_bases
CGGCAACAACACGCGCCCGCGAAAAGACACGCGGTCGTCGTGCGGAACAAGGCGCTGTGGTACACACCGAGAATTTAGCA
CGTTTATTAGAGTTGTCCCG

Downstream 100 bases:

>100_bases
TAGTCGTGGGTGTGCCGGACGGGGTGGGGGCATCCGACGGCGTGACCGGGGCGGTGACCGGGATTTGCGTCGCCGCCGGT
TTGGCCGCCGGTGGCGGTAG

Product: putative short-chain type dehydrogenase/reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALANQIGGTAIVADVTDDAAVEALARALSRVDVL
VNNAGGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALH
RTLRGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVIRPRDQA
SASRRATHPVR

Sequences:

>Translated_251_residues
MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALANQIGGTAIVADVTDDAAVEALARALSRVDVL
VNNAGGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALH
RTLRGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVIRPRDQA
SASRRATHPVR
>Mature_250_residues
TTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALANQIGGTAIVADVTDDAAVEALARALSRVDVLV
NNAGGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALHR
TLRGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVIRPRDQAS
ASRRATHPVR

Specific function: Unknown

COG id: COG4221

COG function: function code R; Short-chain alcohol dehydrogenase of unknown specificity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=34.1269841269841, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI7706318, Length=189, Percent_Identity=35.978835978836, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI20149619, Length=233, Percent_Identity=30.4721030042918, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI32483357, Length=201, Percent_Identity=31.3432835820896, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI40254992, Length=186, Percent_Identity=32.258064516129, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7657478, Length=190, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI5031737, Length=197, Percent_Identity=34.010152284264, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=34.0314136125654, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4557649, Length=185, Percent_Identity=29.1891891891892, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI40548397, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010158, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010156, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22758144, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI10190704, Length=207, Percent_Identity=28.5024154589372, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI126723191, Length=177, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4758504, Length=194, Percent_Identity=32.9896907216495, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787820, Length=240, Percent_Identity=37.9166666666667, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1787335, Length=196, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=32.620320855615, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082100, Length=189, Percent_Identity=35.978835978836, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787905, Length=186, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788459, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87082160, Length=202, Percent_Identity=27.2277227722772, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI2367175, Length=195, Percent_Identity=32.3076923076923, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=242, Percent_Identity=30.5785123966942, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71997402, Length=195, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=261, Percent_Identity=27.9693486590038, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=242, Percent_Identity=29.7520661157025, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17570069, Length=204, Percent_Identity=29.9019607843137, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=30.1158301158301, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=257, Percent_Identity=30.3501945525292, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=244, Percent_Identity=28.2786885245902, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=198, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=194, Percent_Identity=31.9587628865979, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=254, Percent_Identity=29.5275590551181, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=239, Percent_Identity=29.2887029288703, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=238, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=190, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=242, Percent_Identity=28.099173553719, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=241, Percent_Identity=27.8008298755187, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=196, Percent_Identity=29.5918367346939, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=278, Percent_Identity=27.3381294964029, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=246, Percent_Identity=27.6422764227642, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=244, Percent_Identity=28.6885245901639, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=173, Percent_Identity=30.635838150289, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=248, Percent_Identity=37.0967741935484, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322067, Length=194, Percent_Identity=33.5051546391753, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322227, Length=192, Percent_Identity=28.6458333333333, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322226, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=27.7486910994764, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007236, Length=247, Percent_Identity=35.6275303643725, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI23397609, Length=228, Percent_Identity=34.2105263157895, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24641232, Length=250, Percent_Identity=31.6, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571387, Length=248, Percent_Identity=31.8548387096774, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281364494, Length=249, Percent_Identity=30.1204819277108, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24641388, Length=250, Percent_Identity=33.6, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357041, Length=235, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648693, Length=248, Percent_Identity=31.0483870967742, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355889, Length=248, Percent_Identity=31.0483870967742, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648944, Length=244, Percent_Identity=32.3770491803279, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=29.0816326530612, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24663911, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI116007234, Length=249, Percent_Identity=30.9236947791165, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=30.8641975308642, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007238, Length=176, Percent_Identity=35.7954545454545, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571526, Length=190, Percent_Identity=32.6315789473684, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355319, Length=205, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24580925, Length=206, Percent_Identity=28.6407766990291, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161076933, Length=192, Percent_Identity=30.7291666666667, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24584748, Length=192, Percent_Identity=30.7291666666667, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24639444, Length=235, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=196, Percent_Identity=30.6122448979592, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859837, Length=161, Percent_Identity=35.4037267080745, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644339, Length=188, Percent_Identity=27.6595744680851, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): Y484_MYCTU (Q11150)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   G70743
- RefSeq:   NP_214998.1
- RefSeq:   NP_334911.1
- ProteinModelPortal:   Q11150
- SMR:   Q11150
- EnsemblBacteria:   EBMYCT00000003500
- EnsemblBacteria:   EBMYCT00000072273
- GeneID:   887158
- GeneID:   923858
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0502
- KEGG:   mtu:Rv0484c
- TIGR:   MT0502
- TubercuList:   Rv0484c
- GeneTree:   EBGT00050000015153
- HOGENOM:   HBG750976
- OMA:   GDGHVVT
- ProtClustDB:   CLSK790548
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26416; Mature: 26285

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 149-149 BINDING 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALANQIGGTAIVAD
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCEEEEEE
VTDDAAVEALARALSRVDVLVNNAGGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALL
CCCHHHHHHHHHHHHHHHHEEECCCCCCCEEEEECCCHHHHEEEECCCCHHHHHHHHHHH
PKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALHRTLRGELLGKPVRLTEIAPG
HHHHCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
AVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVIRPRDQA
CCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCHH
SASRRATHPVR
HHHHCCCCCCC
>Mature Secondary Structure 
TTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALANQIGGTAIVAD
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCEEEEEE
VTDDAAVEALARALSRVDVLVNNAGGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALL
CCCHHHHHHHHHHHHHHHHEEECCCCCCCEEEEECCCHHHHEEEECCCCHHHHHHHHHHH
PKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALHRTLRGELLGKPVRLTEIAPG
HHHHCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
AVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVIRPRDQA
CCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCHH
SASRRATHPVR
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036