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The map label for this gene is 148660239

Identifier: 148660239

GI number: 148660239

Start: 564033

End: 564737

Strand: Reverse

Name: 148660239

Synonym: MRA_0479

Alternate gene names: NA

Gene position: 564737-564033 (Counterclockwise)

Preceding gene: 148660246

Following gene: 148660238

Centisome position: 12.78

GC content: 62.55

Gene sequence:

>705_bases
GTGGCAGAGCGTATCCCGGCCGTGACCGTGAAGACGGATGGTCGCAAGCGACGCTGGCACCAGCACAAGGTGGAGCGCCG
CAATGAGCTGGTGGACGGCACGATTGAGGCGATTCGCCGGCATGGCCGCTTCCTCAGCATGGACGAGATAGCGGCCGAGA
TCGGGGTCTCCAAGACCGTGCTCTACCGCTACTTCGTCGACAAAAACGACCTGACGACCGCCGTGATGATGCGGTTCACG
CAGACCACCTTGATCCCCAACATGATCGCTGCGCTGTCGGCCGATATGGATGGTTTCGAACTGACCCGCGAAATCATCCG
GGTCTATGTCGAGACCGTGGCGGCCCAACCGGAGCCGTATCGGTTCGTGATGGCGAATAGCTCGGCCAGCAAAAGCAAAG
TGATTGCCGACTCGGAGCGAATCATTGCCCGCATGCTCGCGGTGATGCTGCGCCGCCGCATGCAAGAAGCCGGGATGGAC
ACCGGCGGAGTCGAGCCGTGGGCATATCTGATCGTGGGCGGCGTGCAGCTGGCCACCCACTCCTGGATGTCAGACCCGCG
CATGAGCAGTGACGAACTGATCGACTACCTGACGATGCTGAGCTGGAGCGCACTGTGCGGCATCGTCGAGGCCGGCGGAT
CGTTGGAGAAGTTTCGCGAGCAGCCGCATCCTTCGCCGATCGTGCCTGCCTGGGGGCAGGTCTAG

Upstream 100 bases:

>100_bases
CGACACTGTCCTGCGCACCCCGCGCGCGCGTCCAATGTGCCAGCAGGACCCCCAATTGGCCGTAGTATCGGGAGCGTCTA
GTGAATGGGAATTGGCAACA

Downstream 100 bases:

>100_bases
GCTTTAGGGATGCCCGACGCGGGCGCGGGCTCCCGGCTCAGATCGTGGGCCTACGCACTTCGCACCACCAACCCGCCAGC
TGACGGGCCGACCGACACGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFLSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFT
QTTLIPNMIAALSADMDGFELTREIIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMD
TGGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV

Sequences:

>Translated_234_residues
MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFLSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFT
QTTLIPNMIAALSADMDGFELTREIIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMD
TGGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV
>Mature_233_residues
AERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFLSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQ
TTLIPNMIAALSADMDGFELTREIIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDT
GGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y472_MYCTU (O53757)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   D70829
- RefSeq:   NP_214986.1
- RefSeq:   NP_334898.1
- ProteinModelPortal:   O53757
- EnsemblBacteria:   EBMYCT00000002957
- EnsemblBacteria:   EBMYCT00000071432
- GeneID:   886308
- GeneID:   923837
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0489
- KEGG:   mtu:Rv0472c
- TIGR:   MT0489
- TubercuList:   Rv0472c
- GeneTree:   EBGT00050000014654
- HOGENOM:   HBG564995
- OMA:   QLATHWW
- ProtClustDB:   CLSK790539
- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.357.10

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like; SSF48498 TetR_like_C

EC number: NA

Molecular weight: Translated: 26418; Mature: 26287

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFLSMDEIAAEIGVSKTV
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
LYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELTREIIRVYVETVAAQPEPY
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCE
RFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDTGGVEPWAYLIVGGVQLATH
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRFLSMDEIAAEIGVSKTV
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
LYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELTREIIRVYVETVAAQPEPY
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCE
RFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMDTGGVEPWAYLIVGGVQLATH
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036