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The map label for this gene is 148660231

Identifier: 148660231

GI number: 148660231

Start: 556192

End: 557616

Strand: Reverse

Name: 148660231

Synonym: MRA_0471

Alternate gene names: NA

Gene position: 557616-556192 (Counterclockwise)

Preceding gene: 148660236

Following gene: 148660230

Centisome position: 12.62

GC content: 65.26

Gene sequence:

>1425_bases
GTGTCCAAGACCTACGTCGGCTCGCGGGTCCGCCAACTGCGTAACGAGCGCGGGTTCAGCCAGGCCGCGCTGGCCCAGAT
GCTGGAGATCTCGCCGAGCTATCTGAACCAGATCGAACACGACGTCCGGCCGCTGACCGTGGCCGTGCTGCTGCGCATCA
CCGAAGTGTTCGGGGTGGACGCGACGTTCTTTGCCTCCCAGGACGACACCCGGCTGGTTGCCGAACTCAGGGAGGTGACC
CTGGACCGCGATCTAGACATCGCCATCGACCCGCATGAAGTGGCCGAAATGGTCAGCGCTCATCCCGGGCTGGCCTGCGC
GGTGGTCAACCTGCATCGGCGCTACCGGATCACCACCGCGCAGCTGGCCGCCGCGACCGAGGAGCGGTTCTCCGACGGCA
GTGGCCGAGGGTCGATCACCATGCCGCACGAAGAGGTGCGCGACTACTTCTACCAACGCCAGAACTATCTACATGCGCTG
GACACCGCGGCCGAAGACCTCACGGCCCAGATGCGGATGCACCACGGCGACCTGGCCCGCGAATTGACCCGCCGGCTCAC
CGAGGTGCACGGAGTACGCATCAACAAGCGCATCGACCTCGGTGACACCGTGCTGCACCGCTACGACCCCGCGACCAACA
CGCTGGAGATCAGCAGTCACCTCTCCCCGGGCCAGCAGGTGTTCAAGATGGCCGCCGAGTTGGCCTATCTCGAGTTCGGC
GACCTCATCGACGCCATGGTCACCGACGGCAAGTTCACCAGCGCCGAGTCGCGGACGTTGGCCCGGCTGGGCCTGGCTAA
TTACTTCGCCGCGGCCACCGTGCTGCCCTACCGCCAGTTCCACGACGTCGCCGAGAATTTCCGCTACGACGTCGAGCGGC
TGTCGGCGTTCTACTCGGTGAGCTACGAGACCATCGCCCACCGGCTGTCGACACTACAACGGCCTTCGATGCGCGGGGTC
CCGTTCACCTTCGTCCGGGTGGACCGAGCGGGAAACATGTCAAAACGTCAGTCGGCCACCGGCTTTCACTTCTCCTCCAG
CGGCGGCACCTGCCCGCTGTGGAACGTCTACGAAACGTTTGCCAACCCGGGGAAGATCTTGGTGCAAATCGCCCAGATGC
CCGACGGCCGCAACTACCTGTGGGTGGCCCGCACCGTTGAGCTCCGGGCCGCCCGGTATGGTCAGCCCGGTAAGACCTTC
GCGATCGGGCTGGGCTGCGAACTTCGCCACGCGCACCGGCTCGTCTACTCGGAAGGACTCGACTTGTCGGGTGACCCGAA
TACTGCGGCCACACCTATCGGCGCCGGTTGCCGCGTCTGCGAACGCGACAACTGTCCGCAACGCGCCTTCCCCGCCTTGG
GGCGGGCACTGGATCTCGACGAACACCGCAGCACGGTGTCCCCGTATCTGGTGAAACAACTATGA

Upstream 100 bases:

>100_bases
CCGGTGCGAATCATGCCAACGCCGTGGCGGAAACACCAATCGCAGCACGCTTGCTAACTCTGCGAATGGCGTCTTCACAA
CACCCGGTACGCTCGGTTGG

Downstream 100 bases:

>100_bases
CCGGTCAGAACGGCCAAGTCGCGCGTATCTCCCCGGGGAAGTTCCGCCAGCTGGGGCCGGTCAACTGGCTGGTGGCCAAG
CTGGCCGCACGTGCGGTTGG

Product: putative transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVT
LDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHAL
DTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFG
DLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGV
PFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTF
AIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL

Sequences:

>Translated_474_residues
MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVT
LDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHAL
DTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFG
DLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGV
PFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTF
AIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
>Mature_473_residues
SKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTL
DRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALD
TAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFGD
LIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVP
FTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTFA
IGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL

Specific function: Unknown

COG id: COG3800

COG function: function code R; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH cro/C1-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y465_MYCTU (O53750)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   E70828
- RefSeq:   NP_214979.1
- RefSeq:   NP_334891.1
- ProteinModelPortal:   O53750
- SMR:   O53750
- EnsemblBacteria:   EBMYCT00000002939
- EnsemblBacteria:   EBMYCT00000069505
- GeneID:   886320
- GeneID:   923828
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0481
- KEGG:   mtu:Rv0465c
- TIGR:   MT0481
- TubercuList:   Rv0465c
- GeneTree:   EBGT00050000016556
- HOGENOM:   HBG294134
- OMA:   FRYDIER
- ProtClustDB:   CLSK864508
- GO:   GO:0006350
- InterPro:   IPR018653
- InterPro:   IPR010359
- InterPro:   IPR001387
- InterPro:   IPR010982
- SMART:   SM00530

Pfam domain/function: PF09856 DUF2083; PF06114 DUF955; PF01381 HTH_3; SSF47413 Lambda_like_DNA

EC number: NA

Molecular weight: Translated: 53073; Mature: 52941

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVD
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
ATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTA
EEEECCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHHCCCCCEEHHHHHHHHHEEHHH
QLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLAR
HHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFG
HHHHHHHHHHCEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
DLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETF
HHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHCCCCCEEECCCCCCCCCHHHHHHH
ANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGL
CCCCCEEEEEECCCCCCCEEEEEEEEEHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCC
DLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHCC
>Mature Secondary Structure 
SKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVD
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
ATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTA
EEEECCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHHCCCCCEEHHHHHHHHHEEHHH
QLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLAR
HHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFG
HHHHHHHHHHCEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
DLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETF
HHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHCCCCCEEECCCCCCCCCHHHHHHH
ANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGL
CCCCCEEEEEECCCCCCCEEEEEEEEEHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCC
DLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036