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The map label for this gene is yhhW [C]

Identifier: 148659945

GI number: 148659945

Start: 213637

End: 214371

Strand: Reverse

Name: yhhW [C]

Synonym: MRA_0189

Alternate gene names: 148659945

Gene position: 214371-213637 (Counterclockwise)

Preceding gene: 148659946

Following gene: 148659944

Centisome position: 4.85

GC content: 63.13

Gene sequence:

>735_bases
ATGACCGCCACCGTCGAGATAAGGCGTGCGGCCGACCGGGCGGTCACCACGACGTCCTGGCTGAAATCCCGGCATTCGTT
CTCATTCGGCGACCACTACGATCCCGACAACACCCACCACGGGCTCCTGTTGGTGAACAACGACGACCAAATGGAACCGG
CTTCGGGTTTTGATCCCCATCCACACCGTGACATGGAAATCGTGACCTGGGTGCTGCGGGGAGCGCTCAGACACCAGGAT
TCCGCCGGCAATAGCGGAGTGATCTATCCCGGTCTGGCCCAACGCATGTCGGCCGGCACCGGAATCTTGCATTCGGAAAT
GAACGATTCTGCTACCGAGCCGGTGCATTTCGTGCAGATGTGGGTAATACCCGATGCAACCGGCATCACTGCCAGCTACC
AACAGCAGGAGATAGACGACGAACTGTTGCGCGCCGGCCTGGTAACCATCGCGTCGGGCATACCCGGGCAAGACGCAGCG
CTCACCCTGCATAACAGCAGCGCCTCGTTGCACGGCGCGCGGCTGCGGCCCGGCGCTACGGTCAGCCTGCCCTGCGCACC
CTTCCTGCATCTGTTCGTCGCCTACGGCCGCCTCACTCTGGAAGGTGGCGGCGAGCTTGCCGACGGGGACGCGGTGCGGT
TCACCGACGCTGACGCCCGCGGCCTGACCGCCAATGAGCCGTCGGAAGTACTGATCTGGGAGATGCACGCGAAGCTGGGC
GATTCGGCAACATAG

Upstream 100 bases:

>100_bases
ATGGCCGCCGACCGCGTGTCACACGTGGTGGCCTTCCTCGACACCACCTTGTTCCCGAAATTCGGCCTGCCCGATTCGCT
GTGATGGCGAACGTGACGTC

Downstream 100 bases:

>100_bases
AGTGGCCACGACAGACAGGAGCCCGCATGTCTCAAGCGCAGCCGCGCCCCGCCGCACCCAACCCCAAGCGGAACGTCAAA
GCGATTCGGACGGTGCGTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Putative quercetinase; Pirin-like protein Rv0181c/MT0190

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQD
SAGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAA
LTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLG
DSAT

Sequences:

>Translated_244_residues
MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQD
SAGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAA
LTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLG
DSAT
>Mature_243_residues
TATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDS
AGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAAL
TLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLGD
SAT

Specific function: Putative quercetin 2,3-dioxygenase

COG id: COG1741

COG function: function code R; Pirin-related protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pirin family

Homologues:

Organism=Homo sapiens, GI66363697, Length=197, Percent_Identity=30.4568527918782, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4505823, Length=197, Percent_Identity=30.4568527918782, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789847, Length=232, Percent_Identity=35.3448275862069, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789493, Length=103, Percent_Identity=32.0388349514563, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y181_MYCTU (P65724)

Other databases:

- EMBL:   BX842572
- EMBL:   AE000516
- PIR:   H70905
- RefSeq:   NP_214695.1
- RefSeq:   NP_334596.1
- ProteinModelPortal:   P65724
- SMR:   P65724
- EnsemblBacteria:   EBMYCT00000001653
- EnsemblBacteria:   EBMYCT00000069172
- GeneID:   886788
- GeneID:   923072
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0190
- KEGG:   mtu:Rv0181c
- TIGR:   MT0190
- TubercuList:   Rv0181c
- GeneTree:   EBGT00050000015891
- HOGENOM:   HBG370454
- OMA:   YAYVHVA
- ProtClustDB:   CLSK2748589
- GO:   GO:0005829
- InterPro:   IPR011051
- InterPro:   IPR012093
- InterPro:   IPR003829
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- PANTHER:   PTHR13903
- PIRSF:   PIRSF006232

Pfam domain/function: PF02678 Pirin; SSF51182 RmlC_like_cupin

EC number: =1.13.11.24

Molecular weight: Translated: 26287; Mature: 26155

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPH
CCCEEEHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
PHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQM
CCCCHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHCCCCCEEECCCCCCCCCCEEEEEE
WVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAALTLHNSSASLHGARLRPGAT
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEECCCCE
VSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLG
EECCHHHHHHHHHHHCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCC
DSAT
CCCC
>Mature Secondary Structure 
TATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLLVNNDDQMEPASGFDPH
CCEEEHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
PHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGILHSEMNDSATEPVHFVQM
CCCCHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHCCCCCEEECCCCCCCCCCEEEEEE
WVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAALTLHNSSASLHGARLRPGAT
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEECCCCE
VSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDADARGLTANEPSEVLIWEMHAKLG
EECCHHHHHHHHHHHCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCC
DSAT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036