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The map label for this gene is fadD10 [H]

Identifier: 148659861

GI number: 148659861

Start: 109514

End: 111136

Strand: Direct

Name: fadD10 [H]

Synonym: MRA_0103

Alternate gene names: 148659861

Gene position: 109514-111136 (Clockwise)

Preceding gene: 148659860

Following gene: 148659862

Centisome position: 2.48

GC content: 62.66

Gene sequence:

>1623_bases
ATGGGAGGAAAGAAGTTTCAAGCTATGCCTCAGTTGCCATCTACCGTGCTGGACCGGGTCTTCGAGCAGGCACGGCAGCA
GCCGGAAGCAATCGCCTTGCGTCGCTGCGACGGCACTAGCGCACTGCGGTACCGTGAACTCGTCGCCGAAGTTGGTGGCC
TTGCCGCGGATTTGCGTGCCCAGTCGGTTAGCCGGGGTTCTAGGGTGCTGGTCATTTCCGACAATGGACCCGAGACGTAC
CTGTCGGTGCTGGCGTGTGCAAAGCTCGGGGCGATCGCCGTCATGGCCGACGGCAATCTTCCGATCGCAGCCATCGAACG
ATTCTGTCAGATCACCGACCCCGCAGCGGCTCTCGTCGCACCAGGGAGCAAGATGGCATCTTCCGCCGTTCCCGAGGCGC
TGCACTCGATACCAGTGATCGCGGTCGACATAGCCGCTGTTACACGGGAATCCGAGCATTCCTTGGATGCAGCCAGCCTC
GCCGGGAACGCGGACCAGGGGAGCGAGGATCCGCTGGCGATGATCTTCACCAGCGGTACCACGGGCGAGCCCAAGGCTGT
GCTACTGGCCAACCGCACCTTCTTCGCCGTCCCGGACATCTTGCAAAAAGAGGGTTTGAACTGGGTCACTTGGGTCGTCG
GCGAAACCACCTACTCGCCGCTGCCGGCGACGCACATCGGTGGACTGTGGTGGATACTTACCTGCCTGATGCACGGCGGG
TTGTGTGTCACCGGCGGCGAGAATACGACATCGTTGCTGGAGATTCTCACCACGAACGCGGTGGCGACGACGTGCCTAGT
GCCAACGCTTCTTTCGAAGTTAGTTTCTGAACTGAAGTCCGCCAACGCGACGGTTCCCTCGCTGCGCCTAGTTGGATACG
GTGGTTCGCGGGCGATCGCGGCCGATGTGCGGTTTATCGAAGCTACCGGCGTGCGCACCGCACAGGTCTACGGATTGAGC
GAGACCGGTTGCACGGCTTTGTGTTTGCCGACCGATGACGGCTCGATCGTCAAGATCGAAGCAGGTGCTGTTGGCCGTCC
GTACCCTGGCGTGGACGTCTATCTTGCCGCTACCGATGGCATCGGCCCTACCGCCCCCGGCGCCGGCCCGTCCGCCTCGT
TCGGCACGCTATGGATTAAGTCACCGGCCAACATGCTGGGCTACTGGAACAATCCCGAACGCACCGCAGAGGTGCTGATT
GACGGCTGGGTGAACACCGGTGACCTGCTGGAGCGCCGCGAGGACGGCTTCTTCTACATCAAGGGAAGATCCTCGGAGAT
GATCATCTGTGGTGGCGTGAACATTGCGCCCGACGAGGTCGATCGCATCGCGGAGGGCGTGTCGGGCGTCCGCGAGGCCG
CGTGCTACGAGATTCCTGACGAAGAGTTCGGCGCGCTGGTGGGCCTGGCCGTGGTCGCATCGGCAGAGCTTGACGAGTCG
GCAGCCCGGGCGCTCAAGCACACGATTGCGGCTCGTTTTCGACGGGAGTCCGAGCCGATGGCGCGGCCGTCGACAATTGT
GATCGTCACCGACATTCCACGAACGCAGTCCGGCAAGGTCATGCGGGCCTCGCTTGCAGCGGCGGCAACAGCAGACAAGG
CCAGAGTGGTCGTTCGTGGCTGA

Upstream 100 bases:

>100_bases
CGCTATCTCAAGGTCCCGTGCGTCATCGAGTTCTGGGACGAGAACGGCGGGGCGGCGTCCGGTGAGATCGAACTAGCGGC
CCTCAACATTCCGTAATCCA

Downstream 100 bases:

>100_bases
GCCGGTGCGGGACCGAATCCTCGCCGCCGTCTGCGACGTGTTGTATATCGACGAGGCGGATCTCATTGATGGCGACGAAA
CGGATCTCCGCGACCTCGGG

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETY
LSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASL
AGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGG
LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLS
ETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLI
DGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDES
AARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG

Sequences:

>Translated_540_residues
MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETY
LSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASL
AGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGG
LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLS
ETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLI
DGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDES
AARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
>Mature_539_residues
GGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYL
SVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLA
GNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGL
CVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSE
TGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLID
GWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESA
ARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=532, Percent_Identity=25, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI42544132, Length=513, Percent_Identity=24.3664717348928, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI187761345, Length=398, Percent_Identity=30.6532663316583, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI187761343, Length=398, Percent_Identity=30.6532663316583, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI156151445, Length=539, Percent_Identity=25.7884972170686, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI157311624, Length=550, Percent_Identity=23.2727272727273, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI157311622, Length=550, Percent_Identity=23.2727272727273, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI58082049, Length=546, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI122937307, Length=481, Percent_Identity=24.1164241164241, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI115511026, Length=492, Percent_Identity=23.1707317073171, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI195947378, Length=409, Percent_Identity=23.7163814180929, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1788107, Length=375, Percent_Identity=27.2, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=25.7088846880907, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=26.0038240917782, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790505, Length=575, Percent_Identity=24.5217391304348, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI221142682, Length=513, Percent_Identity=25.1461988304094, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786529, Length=587, Percent_Identity=23.679727427598, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788595, Length=484, Percent_Identity=26.2396694214876, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786801, Length=476, Percent_Identity=22.4789915966387, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=518, Percent_Identity=24.3243243243243, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=520, Percent_Identity=23.6538461538462, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71996755, Length=498, Percent_Identity=24.2971887550201, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17559526, Length=384, Percent_Identity=25.5208333333333, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=535, Percent_Identity=24.1121495327103, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=396, Percent_Identity=26.7676767676768, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=396, Percent_Identity=26.7676767676768, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=396, Percent_Identity=26.7676767676768, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=410, Percent_Identity=24.8780487804878, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=554, Percent_Identity=22.5631768953069, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557194, Length=544, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115534440, Length=554, Percent_Identity=21.1191335740072, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=538, Percent_Identity=23.9776951672862, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323182, Length=585, Percent_Identity=23.2478632478632, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319699, Length=384, Percent_Identity=24.4791666666667, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18859661, Length=422, Percent_Identity=25.1184834123223, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24581924, Length=544, Percent_Identity=25, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648253, Length=541, Percent_Identity=23.1053604436229, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648255, Length=541, Percent_Identity=23.1053604436229, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648257, Length=537, Percent_Identity=22.3463687150838, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24653035, Length=373, Percent_Identity=23.8605898123324, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356947, Length=366, Percent_Identity=25.1366120218579, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355181, Length=399, Percent_Identity=25.31328320802, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076582, Length=392, Percent_Identity=23.2142857142857, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130357, Length=370, Percent_Identity=23.5135135135135, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648260, Length=378, Percent_Identity=21.6931216931217, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 56590; Mature: 56459

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHCCHHHHHHH
QSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVA
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCEEEC
PGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGT
CCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCC
TGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGG
CCCCCEEEEECCEEEECCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEE
ADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDG
EEEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEECC
IGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYI
CCCCCCCCCCCCCCCEEEEECCHHHCCCCCCCHHEEEEEEECCCCCHHHHHHCCCCEEEE
KGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDES
ECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
AARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
GGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRA
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHCCHHHHHHH
QSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVA
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCEEEC
PGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGT
CCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCC
TGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGG
CCCCCEEEEECCEEEECCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEE
ADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDG
EEEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEECC
IGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYI
CCCCCCCCCCCCCCCEEEEECCHHHCCCCCCCHHEEEEEEECCCCCHHHHHHCCCCEEEE
KGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDES
ECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
AARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]