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The map label for this gene is icd2 [H]

Identifier: 148659826

GI number: 148659826

Start: 73632

End: 75869

Strand: Reverse

Name: icd2 [H]

Synonym: MRA_0068

Alternate gene names: 148659826

Gene position: 75869-73632 (Counterclockwise)

Preceding gene: 148659827

Following gene: 148659808

Centisome position: 1.72

GC content: 61.8

Gene sequence:

>2238_bases
ATGAGCGCCGAACAGCCGACCATCATTTACACGCTGACCGACGAGGCGCCGCTGCTGGCGACCTACGCCTTTCTGCCGAT
TGTGCGTGCCTTTGCCGAACCGGCGGGCATCAAGATCGAGGCCAGCGACATCTCTGTAGCGGCACGCATCCTGGCGGAAT
TCCCCGATTACCTGACCGAGGAGCAGCGGGTACCGGATAACCTCGCCGAACTGGGCCGGCTGACTCAGCTACCCGACACC
AACATCATCAAGCTGCCGAACATCAGCGCCTCGGTGCCACAGCTGGTAGCCGCCATCAAGGAACTGCAAGACAAGGGTTA
CGCGGTCCCAGACTACCCGGCGGACCCGAAGACTGACCAGGAGAAGGCCATCAAAGAGCGCTACGCCAGATGCCTGGGCA
GCGCGGTGAACCCGGTACTGCGCCAAGGCAATTCGGACCGTCGGGCGCCCAAGGCGGTGAAGGAGTACGCGCGCAAGCAC
CCGCACAGCATGGGCGAGTGGTCGATGGCCTCACGCACCCACGTAGCGCACATGCGGCACGGTGACTTCTACGCCGGCGA
GAAGTCGATGACACTGGACCGCGCGCGCAACGTGAGGATGGAACTGCTGGCCAAGAGCGGCAAGACGATCGTGCTCAAGC
CCGAGGTGCCGCTGGATGACGGCGACGTCATCGACAGCATGTTCATGAGCAAGAAAGCGCTGTGCGACTTCTACGAAGAG
CAGATGCAGGATGCGTTCGAGACCGGCGTGATGTTCTCCTTGCACGTCAAGGCGACCATGATGAAGGTCAGCCACCCCAT
CGTCTTCGGCCACGCGGTCAGGATCTTCTACAAGGACGCCTTCGCCAAGCACCAGGAGCTGTTCGACGACTTGGGCGTCA
ACGTCAACAATGGCTTGTCCGATCTGTACAGCAAGATCGAGTCGCTGCCGGCGTCGCAACGCGACGAGATCATCGAGGAC
CTACACCGTTGCCACGAACACCGCCCCGAGCTCGCGATGGTCGATTCGGCCAGAGGTATCTCCAACTTCCACTCGCCGAG
CGATGTGATCGTGGACGCCTCGATGCCCGCGATGATTCGCGCGGGCGGCAAGATGTATGGCGCCGACGGAAAGCTCAAGG
ACACCAAGGCGGTCAACCCGGAGTCCACCTTCTCGCGCATCTATCAGGAGATCATCAACTTCTGCAAGACAAATGGCCAG
TTCGATCCGACGACGATGGGCACCGTCCCCAATGTGGGTCTGATGGCCCAGCAGGCCGAGGAGTACGGCTCGCACGACAA
GACGTTCGAGATTCCCGAGGACGGCGTCGCCAACATCGTCGATGTCGCCACCGGCGAGGTGCTGCTGACCGAGAACGTGG
AAGCCGGCGACATCTGGCGCATGTGCATCGTCAAGGACGCACCGATCCGTGACTGGGTCAAGCTGGCTGTCACCCGCGCG
CGCATCTCCGGGATGCCGGTGCTGTTCTGGCTGGACCCGTACCGCCCGCACGAGAACGAGCTGATCAAGAAGGTCAAGAC
ATACCTGAAAGATCACGACACCGAAGGTCTGGACATCCAGATCATGTCGCAAGTGCGATCCATGCGCTACACGTGCGAGC
GCCTGGTCCGTGGACTGGACACCATCGCCGCGACCGGCAACATCCTGCGCGACTACCTCACCGACCTGTTCCCGATCCTG
GAGTTAGGCACCAGCGCCAAGATGCTGTCCGTCGTTCCGCTGATGGCCGGCGGCGGAATGTACGAGACGGGGGCGGGCGG
TTCGGCACCCAAGCACGTCAAACAATTGGTGGAGGAGAATCACCTGCGCTGGGATTCTCTGGGTGAGTTCCTCGCGCTGG
GCGCCGGTTTCGAGGATATCGGCATCAAGACCGGTAACGAGCGGGCCAAACTCTTGGGTAAGACCCTGGATGCCGCCATC
GGCAAGCTGCTGGACAACGACAAGAGTCCGTCGCGCAAAACCGGTGAACTCGACAACCGGGGCAGCCAGTTCTACCTCGC
CATGTACTGGGCACAAGAGCTGGCCGCGCAGACCGACGACCAGCAGCTGGCCGAACACTTCGCCTCGCTGGCAGATGTGT
TGACCAAAAACGAAGACGTCATCGTGCGAGAGCTCACCGAGGTACAAGGCGAACCGGTGGACATCGGCGGCTACTACGCG
CCGGACAGCGACATGACTACGGCGGTGATGCGGCCCAGCAAGACGTTCAATGCAGCGCTGGAGGCTGTCCAAGGCTGA

Upstream 100 bases:

>100_bases
ACCGCCCGAATCATGTGCGGCGCAATCCGCGATACTGGTAACCGCCGCTACAACGCGGAGTGATTCAGCATCTGACCGAC
AGTGACGCCGGGAGAACACC

Downstream 100 bases:

>100_bases
CGACGGGCTGGCCCGGCTACGACGGCGCCATTGGCGTCCCGCAAAGGGATGTCACCGAACGAGTTTGATTTCGCACGGAA
GGCCCGGCGCGGCCGCAAGC

Product: isocitrate dehydrogenase (NADP) Icd2

Products: NA

Alternate protein names: IDH-II; IDP-2; NADP+-specific ICDH 2; Oxalosuccinate decarboxylase 2 [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDT
NIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKH
PHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEE
QMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIED
LHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQ
FDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRA
RISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPIL
ELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAI
GKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYA
PDSDMTTAVMRPSKTFNAALEAVQG

Sequences:

>Translated_745_residues
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDT
NIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKH
PHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEE
QMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIED
LHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQ
FDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRA
RISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPIL
ELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAI
GKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYA
PDSDMTTAVMRPSKTFNAALEAVQG
>Mature_744_residues
SAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTN
IIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHP
HSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEEQ
MQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDL
HRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQF
DPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRAR
ISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILE
LGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIG
KLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAP
DSDMTTAVMRPSKTFNAALEAVQG

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82551; Mature: 82420

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
EQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQ
HHCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEE
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
QMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLS
HHHHHHHHCCEEEEEHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIR
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAE
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
RISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLD
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNR
CCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYA
CCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCEEC
PDSDMTTAVMRPSKTFNAALEAVQG
CCCCCCHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
EQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQ
HHCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEE
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
QMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLS
HHHHHHHHCCEEEEEHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIR
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAE
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
RISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLD
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNR
CCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYA
CCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCEEC
PDSDMTTAVMRPSKTFNAALEAVQG
CCCCCCHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226630; 1295895 [H]