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The map label for this gene is hutC [H]

Identifier: 148652662

GI number: 148652662

Start: 1010433

End: 1011281

Strand: Direct

Name: hutC [H]

Synonym: PsycPRwf_0853

Alternate gene names: 148652662

Gene position: 1010433-1011281 (Clockwise)

Preceding gene: 148652656

Following gene: 148652663

Centisome position: 33.92

GC content: 48.29

Gene sequence:

>849_bases
ATGTTCACTCATTGTGATGAGTATTCTTTACTTTCCTTAATAAATAAGTCTTTTATCATGTCAAAAAAGAAAACAATGGT
GCCAAAGTCTAATTCAAGAGCGAAGCCTGCCTATCAGCGTATTAAAGACAGCATTTTAAAAAATATTCATTCGGGAAAAT
GGCAGGCAGGAGAAGCCATTCCGACGGAACACGCTTTAGCAGATAAATTTTCTGTATCACGAATGACTGTCAATCGTGCG
TTAAAGGAGCTTAGTGAGGAGCGAGTATTACATCGCAGACAAGGTTCGGGCACCTTTGTGGCGCAGCAGCAATACAACCA
TACGGTGGTAGAAGTGCGCAATATCGCCGCTGATATTAAAGCCACAGGCAAGCAGTATAGTGCGCAAGTCATCAGTCAGC
GCCGGGTCGCTGCCAGTGAAGTCAGTCCGCGAATCTTGGCATTATTAACCCAGCCGATGCTGGATATCTCTCCGACACCG
ACCACAGGTCTTGAGCGGCGAGAGGACACCGATCTTATTGATGAGGTAAAGCTGGTACATATCGCCAATGGTAAGCCGCT
ACAATACGAGGAGCGCTGGGTAGATGCCTCATTAGTGCCGCAATTTATCGAGCAAGACTTCAGTGTGGTCAATACCAGCG
ACTATCTGATACAGCAGGCCCCACTACAAGGGGGTAGCTATACCATTCGTGCGGTGGCGGCGCCCAAGCCGGTGGCTAAG
GCTTTAGATTTGGCAGTGGGTGCCCCTGCATTATTGCTCAGTCGTCAGACTTTCTCAGCCGGCCGCGTGGTTACCTTTGT
TAATATGTGGCATGCCGGTGACAGTTATCAGATCTCTGGCACCTTGTAG

Upstream 100 bases:

>100_bases
CCAATTTAAGAGTGCCTTTATTTTTATAGTAAAATTTTTTATAACTAAGTTTGTTGTGATTGGCTAAATTGTATTATTAT
CGCTATATCAATGTTTATGG

Downstream 100 bases:

>100_bases
CTACTTTAGCGTTTGGCTTTGCTGACATTTATATCTGCCAGTATCAGCTCTTTTAAGCCAAAATAAGTAACGCTTCGGCT
GACTTTGACCTTGTGGGTAA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MFTHCDEYSLLSLINKSFIMSKKKTMVPKSNSRAKPAYQRIKDSILKNIHSGKWQAGEAIPTEHALADKFSVSRMTVNRA
LKELSEERVLHRRQGSGTFVAQQQYNHTVVEVRNIAADIKATGKQYSAQVISQRRVAASEVSPRILALLTQPMLDISPTP
TTGLERREDTDLIDEVKLVHIANGKPLQYEERWVDASLVPQFIEQDFSVVNTSDYLIQQAPLQGGSYTIRAVAAPKPVAK
ALDLAVGAPALLLSRQTFSAGRVVTFVNMWHAGDSYQISGTL

Sequences:

>Translated_282_residues
MFTHCDEYSLLSLINKSFIMSKKKTMVPKSNSRAKPAYQRIKDSILKNIHSGKWQAGEAIPTEHALADKFSVSRMTVNRA
LKELSEERVLHRRQGSGTFVAQQQYNHTVVEVRNIAADIKATGKQYSAQVISQRRVAASEVSPRILALLTQPMLDISPTP
TTGLERREDTDLIDEVKLVHIANGKPLQYEERWVDASLVPQFIEQDFSVVNTSDYLIQQAPLQGGSYTIRAVAAPKPVAK
ALDLAVGAPALLLSRQTFSAGRVVTFVNMWHAGDSYQISGTL
>Mature_282_residues
MFTHCDEYSLLSLINKSFIMSKKKTMVPKSNSRAKPAYQRIKDSILKNIHSGKWQAGEAIPTEHALADKFSVSRMTVNRA
LKELSEERVLHRRQGSGTFVAQQQYNHTVVEVRNIAADIKATGKQYSAQVISQRRVAASEVSPRILALLTQPMLDISPTP
TTGLERREDTDLIDEVKLVHIANGKPLQYEERWVDASLVPQFIEQDFSVVNTSDYLIQQAPLQGGSYTIRAVAAPKPVAK
ALDLAVGAPALLLSRQTFSAGRVVTFVNMWHAGDSYQISGTL

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=250, Percent_Identity=28.4, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082252, Length=225, Percent_Identity=27.5555555555556, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790118, Length=244, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 31304; Mature: 31304

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTHCDEYSLLSLINKSFIMSKKKTMVPKSNSRAKPAYQRIKDSILKNIHSGKWQAGEAI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PTEHALADKFSVSRMTVNRALKELSEERVLHRRQGSGTFVAQQQYNHTVVEVRNIAADIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCCCCHHHHHHHHHHHHH
ATGKQYSAQVISQRRVAASEVSPRILALLTQPMLDISPTPTTGLERREDTDLIDEVKLVH
HCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHEEEEE
IANGKPLQYEERWVDASLVPQFIEQDFSVVNTSDYLIQQAPLQGGSYTIRAVAAPKPVAK
ECCCCCCCHHHHHCCHHHHHHHHHCCHHEECCHHHHHEECCCCCCCEEEEEECCCCHHHH
ALDLAVGAPALLLSRQTFSAGRVVTFVNMWHAGDSYQISGTL
HHHHHCCCHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCC
>Mature Secondary Structure
MFTHCDEYSLLSLINKSFIMSKKKTMVPKSNSRAKPAYQRIKDSILKNIHSGKWQAGEAI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PTEHALADKFSVSRMTVNRALKELSEERVLHRRQGSGTFVAQQQYNHTVVEVRNIAADIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCCCCHHHHHHHHHHHHH
ATGKQYSAQVISQRRVAASEVSPRILALLTQPMLDISPTPTTGLERREDTDLIDEVKLVH
HCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHEEEEE
IANGKPLQYEERWVDASLVPQFIEQDFSVVNTSDYLIQQAPLQGGSYTIRAVAAPKPVAK
ECCCCCCCHHHHHCCHHHHHHHHHCCHHEECCHHHHHEECCCCCCCEEEEEECCCCHHHH
ALDLAVGAPALLLSRQTFSAGRVVTFVNMWHAGDSYQISGTL
HHHHHCCCHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]