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The map label for this gene is pcaK [H]

Identifier: 148652550

GI number: 148652550

Start: 882443

End: 883759

Strand: Direct

Name: pcaK [H]

Synonym: PsycPRwf_0741

Alternate gene names: 148652550

Gene position: 882443-883759 (Clockwise)

Preceding gene: 148652549

Following gene: 148652551

Centisome position: 29.62

GC content: 40.85

Gene sequence:

>1317_bases
ATGAAATCAATCGTATTAAAGGATTTTATTGATAGTCGAGCGCTTGGCAATCGTCAGAAGTCTATTATAGCCCTATGTAT
GGCCCTAATGATTTTGGACGGTTATGATATACAAGCGATGGCTTATGCCGCCCCTCTAATTATTAGTGATTGGCAAATTG
ACAAAACCATGTTGGGTGTGGTGTTCAGCTCAAGCTTGGTTGGTTTGTTCTTTGGTTCATTGTTGATTAGTAATTTGTCA
GATCGCTTTGGGCGTCGTATCATTTTGCTAATCTCAACCTTACTGTTTTCGATATTTATGTTAGTCACGCCAATGGCTCA
TAACCTAGAGCAATTGGCGATTTTGCGTTTTGTGACGGGTATTTTTTTGGGCGGTATTATGCCCAATGCTATGGCATATT
GTGCTGAGATTGTGCCAAGCAAATACCGTGTGTTTACAATGATTATGATCTCATCAGGCTTTACCATTGGTGCAATGCTA
GGTGGTTTTGTGGCAACGTGGTTAAAGGCTTATGGGTGGCAAGCAATCTTTTATTTTGGTGGTATCGTCCCCTTAATTTT
GTTTGTGATCATGTTTCTGGCCTTGCCCGAGTCGTTACAATTCTTGGCCTCAAAGCCCAATAATGAGAGCAAGATAAAGT
CAATATTACAGCGCTTTTATCCCAGTGCTACTATATCTAATGACACCACTATCATATTACCTAAGAATGAAACGGTTAAA
GCCTCACCAATAGAATTATTTAAAGAAAATCGCAGCTTTTTTACCATCACTATCTGGATTGCCAGTATGATGAACTTGAT
GAGCTTGTACTTTTTATCAAGTTGGCTACCGACACTGGGTATGGAGGCAGGACTTACCACCACTCAAGCGTTAATGATAG
GCTCAACGTTACAATTTGGCGGTACAGTGGGTAGTTTATTGATGGGAACACGCATCAATAAGCTGGGCTTTTATAAAGTA
TTAATTCCCATCTTTATAGTGGCTGCTCTTAGTGTTGCAATGATTGGCTTTAGTGCAGGCAGTATTGTAGTGCTATTTAT
TGTGGTGTTTATTGCAGGGTTCACGGTTGTCGGTGGACAACCTACACTTAATGCGTTGTCTGCTGAACGCTATCCTACCT
TGCTACGTACAACAGGTGTTGGCTGGAGCTTGGGAATTGGTAGAATTGGATCGATGATAGGCCCGGTTATTGGCGGCTTG
CTCTCAAAATCTTTAACATTAAGTACACTGTTTTTATTTGCAGCAGTGCCTTCAATTGTGGTAGTTATAATGATGATAAT
GCAAGCAAGACACCCTGGTAGTAAGTCTGAGCTTTAG

Upstream 100 bases:

>100_bases
ATTTCTAACTCACTATCTATAGGTTTATTGATGTTGCTCGTTGATAGTAGATGAGTGCTTTGAAAAGTATTTTAAAGTAG
GTGTTAAACAAGGATGTTAC

Downstream 100 bases:

>100_bases
TAACTTAATCTCAGATACAATCTCAGATACGATCTCAGTTACGTTTAAATAAAAAGCTAAGACCATAGGGTATTAACGAA
CAATAATCTAACAAGGAACT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKSIVLKDFIDSRALGNRQKSIIALCMALMILDGYDIQAMAYAAPLIISDWQIDKTMLGVVFSSSLVGLFFGSLLISNLS
DRFGRRIILLISTLLFSIFMLVTPMAHNLEQLAILRFVTGIFLGGIMPNAMAYCAEIVPSKYRVFTMIMISSGFTIGAML
GGFVATWLKAYGWQAIFYFGGIVPLILFVIMFLALPESLQFLASKPNNESKIKSILQRFYPSATISNDTTIILPKNETVK
ASPIELFKENRSFFTITIWIASMMNLMSLYFLSSWLPTLGMEAGLTTTQALMIGSTLQFGGTVGSLLMGTRINKLGFYKV
LIPIFIVAALSVAMIGFSAGSIVVLFIVVFIAGFTVVGGQPTLNALSAERYPTLLRTTGVGWSLGIGRIGSMIGPVIGGL
LSKSLTLSTLFLFAAVPSIVVVIMMIMQARHPGSKSEL

Sequences:

>Translated_438_residues
MKSIVLKDFIDSRALGNRQKSIIALCMALMILDGYDIQAMAYAAPLIISDWQIDKTMLGVVFSSSLVGLFFGSLLISNLS
DRFGRRIILLISTLLFSIFMLVTPMAHNLEQLAILRFVTGIFLGGIMPNAMAYCAEIVPSKYRVFTMIMISSGFTIGAML
GGFVATWLKAYGWQAIFYFGGIVPLILFVIMFLALPESLQFLASKPNNESKIKSILQRFYPSATISNDTTIILPKNETVK
ASPIELFKENRSFFTITIWIASMMNLMSLYFLSSWLPTLGMEAGLTTTQALMIGSTLQFGGTVGSLLMGTRINKLGFYKV
LIPIFIVAALSVAMIGFSAGSIVVLFIVVFIAGFTVVGGQPTLNALSAERYPTLLRTTGVGWSLGIGRIGSMIGPVIGGL
LSKSLTLSTLFLFAAVPSIVVVIMMIMQARHPGSKSEL
>Mature_438_residues
MKSIVLKDFIDSRALGNRQKSIIALCMALMILDGYDIQAMAYAAPLIISDWQIDKTMLGVVFSSSLVGLFFGSLLISNLS
DRFGRRIILLISTLLFSIFMLVTPMAHNLEQLAILRFVTGIFLGGIMPNAMAYCAEIVPSKYRVFTMIMISSGFTIGAML
GGFVATWLKAYGWQAIFYFGGIVPLILFVIMFLALPESLQFLASKPNNESKIKSILQRFYPSATISNDTTIILPKNETVK
ASPIELFKENRSFFTITIWIASMMNLMSLYFLSSWLPTLGMEAGLTTTQALMIGSTLQFGGTVGSLLMGTRINKLGFYKV
LIPIFIVAALSVAMIGFSAGSIVVLFIVVFIAGFTVVGGQPTLNALSAERYPTLLRTTGVGWSLGIGRIGSMIGPVIGGL
LSKSLTLSTLFLFAAVPSIVVVIMMIMQARHPGSKSEL

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=439, Percent_Identity=22.3234624145786, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI166064021, Length=403, Percent_Identity=23.8213399503722, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI213021148, Length=456, Percent_Identity=22.1491228070175, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87081723, Length=401, Percent_Identity=29.925187032419, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082159, Length=399, Percent_Identity=25.8145363408521, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786229, Length=370, Percent_Identity=24.0540540540541, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082404, Length=389, Percent_Identity=21.8508997429306, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082231, Length=441, Percent_Identity=21.5419501133787, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789312, Length=443, Percent_Identity=25.0564334085779, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788068, Length=379, Percent_Identity=24.2744063324538, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=437, Percent_Identity=22.4256292906178, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI193207197, Length=438, Percent_Identity=23.5159817351598, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71980582, Length=361, Percent_Identity=24.0997229916898, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980584, Length=361, Percent_Identity=24.0997229916898, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922616, Length=388, Percent_Identity=23.7113402061856, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922874, Length=402, Percent_Identity=21.6417910447761, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24649618, Length=361, Percent_Identity=22.1606648199446, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47649; Mature: 47649

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIVLKDFIDSRALGNRQKSIIALCMALMILDGYDIQAMAYAAPLIISDWQIDKTMLGV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEECCCHHHHHHHH
VFSSSLVGLFFGSLLISNLSDRFGRRIILLISTLLFSIFMLVTPMAHNLEQLAILRFVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLGGIMPNAMAYCAEIVPSKYRVFTMIMISSGFTIGAMLGGFVATWLKAYGWQAIFYFG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
GIVPLILFVIMFLALPESLQFLASKPNNESKIKSILQRFYPSATISNDTTIILPKNETVK
HHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
ASPIELFKENRSFFTITIWIASMMNLMSLYFLSSWLPTLGMEAGLTTTQALMIGSTLQFG
CCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHC
GTVGSLLMGTRINKLGFYKVLIPIFIVAALSVAMIGFSAGSIVVLFIVVFIAGFTVVGGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCC
PTLNALSAERYPTLLRTTGVGWSLGIGRIGSMIGPVIGGLLSKSLTLSTLFLFAAVPSIV
CCHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVIMMIMQARHPGSKSEL
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKSIVLKDFIDSRALGNRQKSIIALCMALMILDGYDIQAMAYAAPLIISDWQIDKTMLGV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEECCCHHHHHHHH
VFSSSLVGLFFGSLLISNLSDRFGRRIILLISTLLFSIFMLVTPMAHNLEQLAILRFVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLGGIMPNAMAYCAEIVPSKYRVFTMIMISSGFTIGAMLGGFVATWLKAYGWQAIFYFG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
GIVPLILFVIMFLALPESLQFLASKPNNESKIKSILQRFYPSATISNDTTIILPKNETVK
HHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
ASPIELFKENRSFFTITIWIASMMNLMSLYFLSSWLPTLGMEAGLTTTQALMIGSTLQFG
CCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHC
GTVGSLLMGTRINKLGFYKVLIPIFIVAALSVAMIGFSAGSIVVLFIVVFIAGFTVVGGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCC
PTLNALSAERYPTLLRTTGVGWSLGIGRIGSMIGPVIGGLLSKSLTLSTLFLFAAVPSIV
CCHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVIMMIMQARHPGSKSEL
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]