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The map label for this gene is yddQ [H]

Identifier: 148652532

GI number: 148652532

Start: 862824

End: 863372

Strand: Direct

Name: yddQ [H]

Synonym: PsycPRwf_0721

Alternate gene names: 148652532

Gene position: 862824-863372 (Clockwise)

Preceding gene: 148652529

Following gene: 148652533

Centisome position: 28.96

GC content: 44.44

Gene sequence:

>549_bases
ATGAGCACAAAAGTACTTATCGTTGTAGATATTCAAAATGAGTATTTTCCGCAAGGTAAATTATCACTCGTAGGTATCAA
TGAAGCCGCTGATAATGCAGCTTTGGTTATTGCGTCTGCTAGAGAAAAAGGCCATACCGTCATTCATATCCGCCATGAAA
TGCCCTCTATTGATGCGCCGATATTTACGCCTAATACCGATGGTGTAGAGATCCATGAGAAGGTAAAACCGATAGAGGGT
GAAGTCGTCGTTGTGAAGCATTATGCCAATTCATTCCGTGAGACGACTCTGAAAGAGCTGTTAGATAAAGAAGGCATTAA
AGAGGTGACCGTAATTGGCGCCATGAGCCACATGTGTATTGATGCAACCGTTCGCGCGGCAGTGGACTTTGGTTATACCA
CGACCACGATTCATGATGCTTGTGCCACGCTTGATCTTGAATTTAATGGAACGACCGTACCCGCAGCGCAGGTTCATGCC
ACTATTATGGCAGCCATTGAGTTTATGTATGGCGAAGTGATTGATACCCAAACCTGGATTGCACGTTAA

Upstream 100 bases:

>100_bases
TTATTAACCTCTTATGTGTCGATGTAGCCACTCGTTAGTGTAGCATAGAGCTTGTAAAATATACGCCTATACAGTCACTT
TGATAAAAAAAGGAATCATC

Downstream 100 bases:

>100_bases
TACTGAGTGTTTAACCAAACCCTCATTAAGTCGTAAAACAGACTCATCAACAAGAATCTCATTAACAAGGTATCAAATTA
TGAATATAGCGAAATCGCTC

Product: isochorismatase hydrolase

Products: Nicotinate; pyrazinoic acid; NH3 [C]

Alternate protein names: NA

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MSTKVLIVVDIQNEYFPQGKLSLVGINEAADNAALVIASAREKGHTVIHIRHEMPSIDAPIFTPNTDGVEIHEKVKPIEG
EVVVVKHYANSFRETTLKELLDKEGIKEVTVIGAMSHMCIDATVRAAVDFGYTTTTIHDACATLDLEFNGTTVPAAQVHA
TIMAAIEFMYGEVIDTQTWIAR

Sequences:

>Translated_182_residues
MSTKVLIVVDIQNEYFPQGKLSLVGINEAADNAALVIASAREKGHTVIHIRHEMPSIDAPIFTPNTDGVEIHEKVKPIEG
EVVVVKHYANSFRETTLKELLDKEGIKEVTVIGAMSHMCIDATVRAAVDFGYTTTTIHDACATLDLEFNGTTVPAAQVHA
TIMAAIEFMYGEVIDTQTWIAR
>Mature_181_residues
STKVLIVVDIQNEYFPQGKLSLVGINEAADNAALVIASAREKGHTVIHIRHEMPSIDAPIFTPNTDGVEIHEKVKPIEGE
VVVVKHYANSFRETTLKELLDKEGIKEVTVIGAMSHMCIDATVRAAVDFGYTTTTIHDACATLDLEFNGTTVPAAQVHAT
IMAAIEFMYGEVIDTQTWIAR

Specific function: NAD biosynthesis; nicotinamide to NaMN; first step. [C]

COG id: COG1335

COG function: function code Q; Amidases related to nicotinamidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismatase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000868 [H]

Pfam domain/function: PF00857 Isochorismatase [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 19906; Mature: 19775

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKVLIVVDIQNEYFPQGKLSLVGINEAADNAALVIASAREKGHTVIHIRHEMPSIDAP
CCCEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCC
IFTPNTDGVEIHEKVKPIEGEVVVVKHYANSFRETTLKELLDKEGIKEVTVIGAMSHMCI
EECCCCCCEEEHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
DATVRAAVDFGYTTTTIHDACATLDLEFNGTTVPAAQVHATIMAAIEFMYGEVIDTQTWI
HHHHHHHEECCCEEHEEEHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
AR
CC
>Mature Secondary Structure 
STKVLIVVDIQNEYFPQGKLSLVGINEAADNAALVIASAREKGHTVIHIRHEMPSIDAP
CCEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCC
IFTPNTDGVEIHEKVKPIEGEVVVVKHYANSFRETTLKELLDKEGIKEVTVIGAMSHMCI
EECCCCCCEEEHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
DATVRAAVDFGYTTTTIHDACATLDLEFNGTTVPAAQVHATIMAAIEFMYGEVIDTQTWI
HHHHHHHEECCCEEHEEEHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Nicotinamide; pyrazinamide; H2O [C]

Specific reaction: Nicotinamide + H2O = Nicotinate + NH3 pyrazinamide + H2O = pyrazinoic acid + NH3 [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]