| Definition | Psychrobacter sp. PRwf-1 chromosome, complete genome. |
|---|---|
| Accession | NC_009524 |
| Length | 2,978,976 |
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The map label for this gene is hdhA [H]
Identifier: 148652458
GI number: 148652458
Start: 782045
End: 782827
Strand: Direct
Name: hdhA [H]
Synonym: PsycPRwf_0646
Alternate gene names: 148652458
Gene position: 782045-782827 (Clockwise)
Preceding gene: 148652457
Following gene: 148652459
Centisome position: 26.25
GC content: 45.08
Gene sequence:
>783_bases ATGACTCCTTCCAAACTATTCGATTTAACCAATAAGACAGCTATTGTGACCGGTGGCGCCAATGGTATCGGCAAAGCATC TGCTATCCTACTTGCCCAGCACGGTGCTAATGTCGTTATTGCCGACCTAAAATTAGACGATGCACAAAAAGTCGCTAAAG AGATAACTGCTCTAGAGGACACAGATGCTCAAGCATTGGCCATTGAGTGCAATATTTTAAAAGATGATAACTTAACCAAT CTTGTTGATAAAACCATTGAGACATTCGGTGCGGTTCATATCCTGATTAATAATGCTGGCGGCGGGGGCGGTGGAAAAGA AAACCCCTTTGAGATAGACGTTAGTGATTTTAAACGTGATTTTGAGCTGAACGTATTTAGCGGTTGGCGTCTATGTCAGC TGGTTGTGCCACATATGAAAAAAGCAGGTTATGGCTCTATTATCTTCACGACCTCTATGGCCAGCATCAATAAAAGCCCT AACATGAGCGGTTATGCCAGCTCAAAAGCTGCGGTTAATCATATGGTCGCAAACCTTGCTCACGACTTTGGCCCAGAAGT ACGCATTAATGCCGTAGGACCAGGCGCCACCAAAACAGACGCTCTGCAAACGGTGTTAACGCCTGAGCTTGAAGATAAGA TGTTAGAGCATACTCCAATTAAGCGCTTAGGCGAACCTGAAGATATTGCAGGGGCTATGCTGTACTTTGCCTCTCCCATA TCTGAGTGGGTGAGTGGACAGACCTTATTTGTAAATGGTGGTGGCACGCAGACGTTAGATTGA
Upstream 100 bases:
>100_bases ATCCAAGGTGTTCTACCCAAAGCAAACAATCGCTTACCCATACAGCCCATTACTTTTGTTATGGTGTCTATCTATCAACA TTAACAAAAGTACTACTGCT
Downstream 100 bases:
>100_bases TAATAGCAACTTTTAAACTTGCCCTTTTATAGTCAAGTCAAGGTAAAAGTGCTACCCGTTACTCTATGCAGTGCTTTTAA ATTAAGGTTCTGTATTTACA
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 260; Mature: 259
Protein sequence:
>260_residues MTPSKLFDLTNKTAIVTGGANGIGKASAILLAQHGANVVIADLKLDDAQKVAKEITALEDTDAQALAIECNILKDDNLTN LVDKTIETFGAVHILINNAGGGGGGKENPFEIDVSDFKRDFELNVFSGWRLCQLVVPHMKKAGYGSIIFTTSMASINKSP NMSGYASSKAAVNHMVANLAHDFGPEVRINAVGPGATKTDALQTVLTPELEDKMLEHTPIKRLGEPEDIAGAMLYFASPI SEWVSGQTLFVNGGGTQTLD
Sequences:
>Translated_260_residues MTPSKLFDLTNKTAIVTGGANGIGKASAILLAQHGANVVIADLKLDDAQKVAKEITALEDTDAQALAIECNILKDDNLTN LVDKTIETFGAVHILINNAGGGGGGKENPFEIDVSDFKRDFELNVFSGWRLCQLVVPHMKKAGYGSIIFTTSMASINKSP NMSGYASSKAAVNHMVANLAHDFGPEVRINAVGPGATKTDALQTVLTPELEDKMLEHTPIKRLGEPEDIAGAMLYFASPI SEWVSGQTLFVNGGGTQTLD >Mature_259_residues TPSKLFDLTNKTAIVTGGANGIGKASAILLAQHGANVVIADLKLDDAQKVAKEITALEDTDAQALAIECNILKDDNLTNL VDKTIETFGAVHILINNAGGGGGGKENPFEIDVSDFKRDFELNVFSGWRLCQLVVPHMKKAGYGSIIFTTSMASINKSPN MSGYASSKAAVNHMVANLAHDFGPEVRINAVGPGATKTDALQTVLTPELEDKMLEHTPIKRLGEPEDIAGAMLYFASPIS EWVSGQTLFVNGGGTQTLD
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=32.9457364341085, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=31.6793893129771, Blast_Score=112, Evalue=2e-25, Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=31.640625, Blast_Score=105, Evalue=5e-23, Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=31.25, Blast_Score=105, Evalue=6e-23, Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=27.0588235294118, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=28.6343612334802, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=31.5789473684211, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=26.0162601626016, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI7706318, Length=210, Percent_Identity=24.2857142857143, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI4503301, Length=234, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI66933014, Length=257, Percent_Identity=27.6264591439689, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI40254986, Length=214, Percent_Identity=27.1028037383178, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI20149619, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=50.5747126436782, Blast_Score=236, Evalue=2e-63, Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=32.6848249027237, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=30.2788844621514, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=29.4820717131474, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=27.7777777777778, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=28.1853281853282, Blast_Score=101, Evalue=5e-23, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=28.8, Blast_Score=94, Evalue=9e-21, Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=31.2, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=26.7206477732794, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=29.3650793650794, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1786812, Length=260, Percent_Identity=25.3846153846154, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=26.2548262548263, Blast_Score=77, Evalue=8e-16, Organism=Escherichia coli, GI1787526, Length=245, Percent_Identity=25.3061224489796, Blast_Score=77, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17561402, Length=264, Percent_Identity=34.0909090909091, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=31.5589353612167, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=28.8461538461538, Blast_Score=111, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=30.3030303030303, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI17562904, Length=276, Percent_Identity=28.9855072463768, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=29.1187739463602, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=29.368029739777, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=27.906976744186, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=28.7313432835821, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=27.3764258555133, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=28.7878787878788, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=29.8387096774194, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=30.2788844621514, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=29.6992481203008, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=28.6792452830189, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=29.8387096774194, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=30.8300395256917, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=26.7175572519084, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=26.615969581749, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=26.4925373134328, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=29.8804780876494, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=27.8625954198473, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=26.8774703557312, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17536025, Length=276, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=28.7937743190661, Blast_Score=67, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17568967, Length=187, Percent_Identity=30.4812834224599, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17508895, Length=171, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=28.2868525896414, Blast_Score=99, Evalue=7e-22, Organism=Saccharomyces cerevisiae, GI6322226, Length=189, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6323882, Length=196, Percent_Identity=27.0408163265306, Blast_Score=66, Evalue=5e-12, Organism=Saccharomyces cerevisiae, GI6322861, Length=242, Percent_Identity=26.0330578512397, Blast_Score=66, Evalue=6e-12, Organism=Drosophila melanogaster, GI21355319, Length=265, Percent_Identity=27.9245283018868, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=32.9365079365079, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=31.6, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=27.9527559055118, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=27.6, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=32.03125, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=26.3779527559055, Blast_Score=90, Evalue=2e-18, Organism=Drosophila melanogaster, GI17737361, Length=234, Percent_Identity=27.3504273504274, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24580925, Length=209, Percent_Identity=28.7081339712919, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI281364892, Length=204, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24641232, Length=244, Percent_Identity=26.2295081967213, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24649181, Length=200, Percent_Identity=27.5, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24640492, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=24.7524752475248, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI21356301, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 27556; Mature: 27424
Theoretical pI: Translated: 4.82; Mature: 4.82
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTPSKLFDLTNKTAIVTGGANGIGKASAILLAQHGANVVIADLKLDDAQKVAKEITALED CCCHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHCCC TDAQALAIECNILKDDNLTNLVDKTIETFGAVHILINNAGGGGGGKENPFEIDVSDFKRD CCCEEEEEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCEEEEHHHCCCC FELNVFSGWRLCQLVVPHMKKAGYGSIIFTTSMASINKSPNMSGYASSKAAVNHMVANLA EEEEEECCHHHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHH HDFGPEVRINAVGPGATKTDALQTVLTPELEDKMLEHTPIKRLGEPEDIAGAMLYFASPI HHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHH SEWVSGQTLFVNGGGTQTLD HHHHCCCEEEEECCCCCCCC >Mature Secondary Structure TPSKLFDLTNKTAIVTGGANGIGKASAILLAQHGANVVIADLKLDDAQKVAKEITALED CCHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHCCC TDAQALAIECNILKDDNLTNLVDKTIETFGAVHILINNAGGGGGGKENPFEIDVSDFKRD CCCEEEEEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCEEEEHHHCCCC FELNVFSGWRLCQLVVPHMKKAGYGSIIFTTSMASINKSPNMSGYASSKAAVNHMVANLA EEEEEECCHHHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHH HDFGPEVRINAVGPGATKTDALQTVLTPELEDKMLEHTPIKRLGEPEDIAGAMLYFASPI HHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHH SEWVSGQTLFVNGGGTQTLD HHHHCCCEEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]