Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 148652032

GI number: 148652032

Start: 256323

End: 257633

Strand: Direct

Name: moeA [H]

Synonym: PsycPRwf_0216

Alternate gene names: 148652032

Gene position: 256323-257633 (Clockwise)

Preceding gene: 148652031

Following gene: 148652033

Centisome position: 8.6

GC content: 51.56

Gene sequence:

>1311_bases
ATGATCACTGTTGCTGAGCTACAAGCTGCCATTACTGAGCGTATTAATAGTTACAATCAAACCGATTCAAGCTTGACGCA
GCGCACCACAGAGCGCCGTGATCTATTGGCCAGTCAGCATCATATTTTAGCGACCGATATCATCTCGCCCTTTGATGTGC
CGCGTCAGAATTTATCGGCCATGGACGGCTATGCGCTTGCCGGTGGTAGTACTCTTGACGCGGGCAGTTACATTGAGATT
GTGGGCGAGTCACAAGCCGGCGCGCCTTTTAGCGGCAGTAGTGTAACTGGTGAGGCACAATTACAGCCAGGCCAAGGCGT
GCGTATTTTTACCGGCGCCGTCGTGCCCAGCGACTGTGATACCGTGGTGATGCAAGAGAACACCAATTTTGCGGCTATCA
AAGACGGCATTGATAAATCCCAAAGCTATCAGATTCAGCTCACCAAAACGGCGGTGGCCGGCAATAATATCCGCCGCCAA
GGCGAGGAGATTGAATCCGGTGAGGTGGTGCTGCACGCTGGCAAACGCTTGAACCCTGCTGATATTAGCTTACTTGCCAA
TTTGGGCGTGGCCCAAGTTGAGGTGTATCAGCCGCTGACGGTGGGTATCTTAGCCACAGGAGATGAGCTGGTCGCGGTCG
GTGAGCCGCTACAAAGCTTGGCACAGATTTACAACTCTAATACGCCAACCCTCAAGAGTATGCTTGCGCATTTGCCCATA
CAGATTCATGATTATGGCATCATCCCCGATGACTTAGAGCGCACCAAGCAGGCGGTATTAACGGCGATGCAAGAATGTGA
TGTGGTGATCTCAACCGCTGGGGTGTCGGTGGGCGATTATGACTTTTTAACCACTGTGATTGAAGACTTAGGGCAGATTA
ACCATTACAAAGTGGCGATGAAGCCGGGCAAGCCTTTTGTGTTTGGGGAATTAAACAAAGACCTTTCGGTGCCAGTATTA
TACTTTGGACTGCCCGGTAATCCGTTATCGTCTGTGGTGGGCAGTTTGCAGTTTATTATTCCTGCCCTATGGCGCTTATC
GGGTATCGATGTGGCAGACATGCCGCTGCCATTGACTGTTACTGCTACTTTGTCTAGCGATGTCAAAAAGTCGCCAGGCC
GCGCCGATTTTCAGCGCGGTATTGTCAGTCAAAATGAGGCGGGGGAGTATGTGGTGACCCCTGCTGGCAAACAAGATTCG
CACCGCATCAAGCAGTTAAGCCATGCTAATTGTCTGATTGTGTTGCCCCAGCAGTCGGGCAGTATGAGCGCCGGTGAACA
GGTGACGGTGCAGCTGTTTCCTTGGAGCTAA

Upstream 100 bases:

>100_bases
ACAAGCCTTGGAAGACATGGCCGAGGCCGAGTAGAATGGGGTATGATGTTAGGACTTATCAAGCCTGTGAATAACCCGAT
TAATCAAAGAGAGCGTATTT

Downstream 100 bases:

>100_bases
TGGGCTTGAGGGAACTGGCTGTGCGCTATATAAGCGCTATCTAGGTGCTATATATGCCCTAGCTAGGCGCTATGCTGGGT
CATAGCGCTTATAAATGTTG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MITVAELQAAITERINSYNQTDSSLTQRTTERRDLLASQHHILATDIISPFDVPRQNLSAMDGYALAGGSTLDAGSYIEI
VGESQAGAPFSGSSVTGEAQLQPGQGVRIFTGAVVPSDCDTVVMQENTNFAAIKDGIDKSQSYQIQLTKTAVAGNNIRRQ
GEEIESGEVVLHAGKRLNPADISLLANLGVAQVEVYQPLTVGILATGDELVAVGEPLQSLAQIYNSNTPTLKSMLAHLPI
QIHDYGIIPDDLERTKQAVLTAMQECDVVISTAGVSVGDYDFLTTVIEDLGQINHYKVAMKPGKPFVFGELNKDLSVPVL
YFGLPGNPLSSVVGSLQFIIPALWRLSGIDVADMPLPLTVTATLSSDVKKSPGRADFQRGIVSQNEAGEYVVTPAGKQDS
HRIKQLSHANCLIVLPQQSGSMSAGEQVTVQLFPWS

Sequences:

>Translated_436_residues
MITVAELQAAITERINSYNQTDSSLTQRTTERRDLLASQHHILATDIISPFDVPRQNLSAMDGYALAGGSTLDAGSYIEI
VGESQAGAPFSGSSVTGEAQLQPGQGVRIFTGAVVPSDCDTVVMQENTNFAAIKDGIDKSQSYQIQLTKTAVAGNNIRRQ
GEEIESGEVVLHAGKRLNPADISLLANLGVAQVEVYQPLTVGILATGDELVAVGEPLQSLAQIYNSNTPTLKSMLAHLPI
QIHDYGIIPDDLERTKQAVLTAMQECDVVISTAGVSVGDYDFLTTVIEDLGQINHYKVAMKPGKPFVFGELNKDLSVPVL
YFGLPGNPLSSVVGSLQFIIPALWRLSGIDVADMPLPLTVTATLSSDVKKSPGRADFQRGIVSQNEAGEYVVTPAGKQDS
HRIKQLSHANCLIVLPQQSGSMSAGEQVTVQLFPWS
>Mature_436_residues
MITVAELQAAITERINSYNQTDSSLTQRTTERRDLLASQHHILATDIISPFDVPRQNLSAMDGYALAGGSTLDAGSYIEI
VGESQAGAPFSGSSVTGEAQLQPGQGVRIFTGAVVPSDCDTVVMQENTNFAAIKDGIDKSQSYQIQLTKTAVAGNNIRRQ
GEEIESGEVVLHAGKRLNPADISLLANLGVAQVEVYQPLTVGILATGDELVAVGEPLQSLAQIYNSNTPTLKSMLAHLPI
QIHDYGIIPDDLERTKQAVLTAMQECDVVISTAGVSVGDYDFLTTVIEDLGQINHYKVAMKPGKPFVFGELNKDLSVPVL
YFGLPGNPLSSVVGSLQFIIPALWRLSGIDVADMPLPLTVTATLSSDVKKSPGRADFQRGIVSQNEAGEYVVTPAGKQDS
HRIKQLSHANCLIVLPQQSGSMSAGEQVTVQLFPWS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=404, Percent_Identity=34.1584158415842, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI66932975, Length=404, Percent_Identity=34.1584158415842, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1787049, Length=406, Percent_Identity=39.1625615763547, Blast_Score=267, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI25147659, Length=381, Percent_Identity=27.2965879265092, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=382, Percent_Identity=26.9633507853403, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17136978, Length=397, Percent_Identity=30.7304785894207, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24638841, Length=397, Percent_Identity=30.7304785894207, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46612; Mature: 46612

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVAELQAAITERINSYNQTDSSLTQRTTERRDLLASQHHILATDIISPFDVPRQNLSA
CEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHH
MDGYALAGGSTLDAGSYIEIVGESQAGAPFSGSSVTGEAQLQPGQGVRIFTGAVVPSDCD
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCC
TVVMQENTNFAAIKDGIDKSQSYQIQLTKTAVAGNNIRRQGEEIESGEVVLHAGKRLNPA
EEEEECCCCEEEECCCCCCCCCEEEEEEEEEECCCCHHHCCCCCCCCCEEEECCCCCCHH
DISLLANLGVAQVEVYQPLTVGILATGDELVAVGEPLQSLAQIYNSNTPTLKSMLAHLPI
HHHHHHCCCEEEEEEECCEEEEEEECCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHCCE
QIHDYGIIPDDLERTKQAVLTAMQECDVVISTAGVSVGDYDFLTTVIEDLGQINHYKVAM
EEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEE
KPGKPFVFGELNKDLSVPVLYFGLPGNPLSSVVGSLQFIIPALWRLSGIDVADMPLPLTV
CCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
TATLSSDVKKSPGRADFQRGIVSQNEAGEYVVTPAGKQDSHRIKQLSHANCLIVLPQQSG
EEECCCHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCEEEEEECCCC
SMSAGEQVTVQLFPWS
CCCCCCEEEEEEECCC
>Mature Secondary Structure
MITVAELQAAITERINSYNQTDSSLTQRTTERRDLLASQHHILATDIISPFDVPRQNLSA
CEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHH
MDGYALAGGSTLDAGSYIEIVGESQAGAPFSGSSVTGEAQLQPGQGVRIFTGAVVPSDCD
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCC
TVVMQENTNFAAIKDGIDKSQSYQIQLTKTAVAGNNIRRQGEEIESGEVVLHAGKRLNPA
EEEEECCCCEEEECCCCCCCCCEEEEEEEEEECCCCHHHCCCCCCCCCEEEECCCCCCHH
DISLLANLGVAQVEVYQPLTVGILATGDELVAVGEPLQSLAQIYNSNTPTLKSMLAHLPI
HHHHHHCCCEEEEEEECCEEEEEEECCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHCCE
QIHDYGIIPDDLERTKQAVLTAMQECDVVISTAGVSVGDYDFLTTVIEDLGQINHYKVAM
EEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEE
KPGKPFVFGELNKDLSVPVLYFGLPGNPLSSVVGSLQFIIPALWRLSGIDVADMPLPLTV
CCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
TATLSSDVKKSPGRADFQRGIVSQNEAGEYVVTPAGKQDSHRIKQLSHANCLIVLPQQSG
EEECCCHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCEEEEEECCCC
SMSAGEQVTVQLFPWS
CCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]