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The map label for this gene is tmk

Identifier: 148651943

GI number: 148651943

Start: 148636

End: 149262

Strand: Direct

Name: tmk

Synonym: PsycPRwf_0126

Alternate gene names: 148651943

Gene position: 148636-149262 (Clockwise)

Preceding gene: 148651942

Following gene: 148651945

Centisome position: 4.99

GC content: 50.24

Gene sequence:

>627_bases
TTGAGTCTAGGTAAGTTTGTAAGCTTTGAAGGCACCGAAGGGGTAGGAAAAACCACAGCGATTAATGGCTTGTGTGAGCG
CTTGCAAGCTCAAGGCATCGAGTATGTCCGCACCCGTGAGCCAGGCGGAAGCCCCTTTGCTGAGCAGCTGCGTGAGTTGT
TGTTAGACACACGTACTCAGATTAATGATGACACTGAGCTGTTATTGATGTTTGCTGCGCGCAGTGACCATCTAGCGCAA
GTTATTATGCCGGCATTAAGCGCAGGCAAATGGGTGATCTGTGATCGCTTTATTGACTCTACTGTGGCCTATCAAGGCTA
TGGACGAGGCTTTGGAAATGCCGATATGCTACATAAAATCGAGGCTCTTATTGCAGGGTTTGTACCGCGTTTACCTGACA
TTACCTTGTGGTTAGATCTGCCAGTCGCCGAGGGCATGCAGCGCGCCGGCAAACGTAGTGTAGCTGACCGCTTTGAACAG
CAGCAACTTGATTTCTTTGATCGTGTTTATCAAGGTTTTGAGGCTCAGCAGCAAGCACAGCCGCAGCGCATTCAGCGTAT
CGACGCTCAAGGTGAGGTAGAGCAAGTGGCGGATAGAATTTGGCAGTCAGTCAGCCAGCAGCTATAG

Upstream 100 bases:

>100_bases
AATAAGTAGATGTAGGCGAACAACAAGTACGCCTATTATATGTGGGAAAAACACCCTGATATTAACAAGGGTGATACTGG
CAACAACGAGGTAATCGACA

Downstream 100 bases:

>100_bases
CGGGGCAGCCTAAGGGTGAGACTTTGCCTTTGCTTCAATGACCCACTTCACCTCTTGCCAAGCTTTATTTTGCTAAGTTT
TGAGTCATAAAAGAGAGCAG

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSLGKFVSFEGTEGVGKTTAINGLCERLQAQGIEYVRTREPGGSPFAEQLRELLLDTRTQINDDTELLLMFAARSDHLAQ
VIMPALSAGKWVICDRFIDSTVAYQGYGRGFGNADMLHKIEALIAGFVPRLPDITLWLDLPVAEGMQRAGKRSVADRFEQ
QQLDFFDRVYQGFEAQQQAQPQRIQRIDAQGEVEQVADRIWQSVSQQL

Sequences:

>Translated_208_residues
MSLGKFVSFEGTEGVGKTTAINGLCERLQAQGIEYVRTREPGGSPFAEQLRELLLDTRTQINDDTELLLMFAARSDHLAQ
VIMPALSAGKWVICDRFIDSTVAYQGYGRGFGNADMLHKIEALIAGFVPRLPDITLWLDLPVAEGMQRAGKRSVADRFEQ
QQLDFFDRVYQGFEAQQQAQPQRIQRIDAQGEVEQVADRIWQSVSQQL
>Mature_207_residues
SLGKFVSFEGTEGVGKTTAINGLCERLQAQGIEYVRTREPGGSPFAEQLRELLLDTRTQINDDTELLLMFAARSDHLAQV
IMPALSAGKWVICDRFIDSTVAYQGYGRGFGNADMLHKIEALIAGFVPRLPDITLWLDLPVAEGMQRAGKRSVADRFEQQ
QLDFFDRVYQGFEAQQQAQPQRIQRIDAQGEVEQVADRIWQSVSQQL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=207, Percent_Identity=42.0289855072464, Blast_Score=140, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PSYWF (A5WBP5)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001279036.1
- ProteinModelPortal:   A5WBP5
- SMR:   A5WBP5
- STRING:   A5WBP5
- GeneID:   5205295
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0126
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK838834
- BioCyc:   PSP56811:PSYCPRWF_0126-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23366; Mature: 23235

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGKFVSFEGTEGVGKTTAINGLCERLQAQGIEYVRTREPGGSPFAEQLRELLLDTRTQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHC
INDDTELLLMFAARSDHLAQVIMPALSAGKWVICDRFIDSTVAYQGYGRGFGNADMLHKI
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCHHHHHHH
EALIAGFVPRLPDITLWLDLPVAEGMQRAGKRSVADRFEQQQLDFFDRVYQGFEAQQQAQ
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
PQRIQRIDAQGEVEQVADRIWQSVSQQL
HHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLGKFVSFEGTEGVGKTTAINGLCERLQAQGIEYVRTREPGGSPFAEQLRELLLDTRTQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHC
INDDTELLLMFAARSDHLAQVIMPALSAGKWVICDRFIDSTVAYQGYGRGFGNADMLHKI
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCHHHHHHH
EALIAGFVPRLPDITLWLDLPVAEGMQRAGKRSVADRFEQQQLDFFDRVYQGFEAQQQAQ
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
PQRIQRIDAQGEVEQVADRIWQSVSQQL
HHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA