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The map label for this gene is ubiB [H]

Identifier: 148550833

GI number: 148550833

Start: 303802

End: 305307

Strand: Reverse

Name: ubiB [H]

Synonym: Swit_5397

Alternate gene names: 148550833

Gene position: 305307-303802 (Counterclockwise)

Preceding gene: 148550834

Following gene: 148550827

Centisome position: 98.41

GC content: 67.2

Gene sequence:

>1506_bases
ATGTTGAAAAGCTTGATGGTAGCGGCCCGGGACCGGGAGCGTCTTGGTGAGGTCACCGGGGTCCTGGCGCGCTATGGCCT
CGACACGGCGATCGACCGGCTCGGCCTGGGCGCCAAAGATCTTCTTGCGGGCGAGGCAGCGGCGCTGCCCGCACGCACGC
GCCTGGCGCTGGAGGAATTGGGTCCCACCTTCGTCAAGCTCGGACAAATTCTCGCCACGCGCAGCGATCTTCTTCCTCCC
GACTGGATCACCGAATTGGAGCGGCTTCACAGCCAGGCGGCGACGCTCCCGTTCGAAATGGTGCGGCCCGCCATCGAGGA
GGCTTTGGGAGAACCTGTCGGCAAGGCGTTCGCCGCGTTCGATCCCGAGCCGCTGGCCGCCGCTTCGATGGCGCAGGTCC
ACCGCGCCCACCTGCACGATGGTCGCGCCATCGTCCTCAAGGTCCGGCGGCCCGGCATCCGTCCCCGCATGGAAGCGGAT
CTGCGCCTCATCGCCCAGTTCGCGGCGGTACTCGAGCGGGCCAGTGCGGAAATCCGGCGCTTTGCGCCCACCGCGCTCGT
CCAACAGCTCGCTTCCGCAATCCTGGAAGAACTCGACTTCACCAACGAGGCCCGCAATGCCGACCGCTTGCGCGCCGACC
TCGTCGGCAACGCGCAGGTCGTCATTCCCGGGATCCACTGGGAATGGACGTCGGAAACGCTCCTCGCCATGGATTATGTC
GAAGGGGTCGCGCCGCGCTCGGCAGAGGCCCTCGTCCAGGCGGACATCGATCCCCACGCGATCGCATCGCTCGGCGCCCA
GGTCGTGCTCGACATGGTCCTTCTCACCGGGCGGTTCCATGCCGATCCCCACCCCGGCAATCTCCTGTGCTTGCCCGGAA
ACCGCCTCGCCTTGCTGGATCTAGGCCTCATCGGCCATGTCAGCCCCCGGCGCCGGGAAGAGCTTTTGCGCTTCGTCCAG
GCCATCAATATCGGGGATCCGCAGGCCCTGGCGGAGACGCTCACCCTGTGGTCCGCCGGTGAGAGCCCGCCTCGCGAGCG
GCTCCTTCTGGCGGCCGAACAGCTTGTCGCCCGCCATGGCGGCACGCGCCTGGTGCTCGCCACCCTGGTCAACGATTTTT
TCGCGCTCATGCGGCAGGAGCGGCTGACCGTCCCGCCCGACCTGCTCCTCATCTTCAAGGCACTGGTGACGCTCGATGGC
GTCCTCGCCAACATCGCCCCCGGCTTCGACCTGACCCTTGCCCTGCGGCAGGCTGCAGTGCGCATCGTTGCCTCGCGCCT
CGATCCTGCTGCCTGGACCCCGGTACTCCAAGGTCTGCTGCTTGAGATCACAAGGATCGGGCAGGATGGCCCGCGGCTGC
TGAGGCTGATCATCGAGCGGCTGGAGCGCGATCAATTCATCCCTCCGCAGCGTGGGGGCACGGAGATCGCCGCGGCCGGG
CGGTGGATCGCGGGCGCCATTGTCGCAGGATCCCTCATCCTCGCGGCCGCTCTGATGCTTTTCTAA

Upstream 100 bases:

>100_bases
TTCCGCTCAGCCGCACGACCCACGTTCCTGCCGGCGCACCGCGCCGGTCGCGAAAACGTCGCCCCTTCGTTTCTGGTGCG
CAGCGCCTATCTCTGGGGCC

Downstream 100 bases:

>100_bases
GGCGCCCCTGATGGAGGCTTGCCGCTCCGCGGCTGCCTTTTCAGGCGGCCGAGACGCGGTCCTCAATCACGCGGAGCAAT
TCGCGATGGTCGACCGGCTT

Product: 2-octaprenylphenol hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MLKSLMVAARDRERLGEVTGVLARYGLDTAIDRLGLGAKDLLAGEAAALPARTRLALEELGPTFVKLGQILATRSDLLPP
DWITELERLHSQAATLPFEMVRPAIEEALGEPVGKAFAAFDPEPLAAASMAQVHRAHLHDGRAIVLKVRRPGIRPRMEAD
LRLIAQFAAVLERASAEIRRFAPTALVQQLASAILEELDFTNEARNADRLRADLVGNAQVVIPGIHWEWTSETLLAMDYV
EGVAPRSAEALVQADIDPHAIASLGAQVVLDMVLLTGRFHADPHPGNLLCLPGNRLALLDLGLIGHVSPRRREELLRFVQ
AINIGDPQALAETLTLWSAGESPPRERLLLAAEQLVARHGGTRLVLATLVNDFFALMRQERLTVPPDLLLIFKALVTLDG
VLANIAPGFDLTLALRQAAVRIVASRLDPAAWTPVLQGLLLEITRIGQDGPRLLRLIIERLERDQFIPPQRGGTEIAAAG
RWIAGAIVAGSLILAAALMLF

Sequences:

>Translated_501_residues
MLKSLMVAARDRERLGEVTGVLARYGLDTAIDRLGLGAKDLLAGEAAALPARTRLALEELGPTFVKLGQILATRSDLLPP
DWITELERLHSQAATLPFEMVRPAIEEALGEPVGKAFAAFDPEPLAAASMAQVHRAHLHDGRAIVLKVRRPGIRPRMEAD
LRLIAQFAAVLERASAEIRRFAPTALVQQLASAILEELDFTNEARNADRLRADLVGNAQVVIPGIHWEWTSETLLAMDYV
EGVAPRSAEALVQADIDPHAIASLGAQVVLDMVLLTGRFHADPHPGNLLCLPGNRLALLDLGLIGHVSPRRREELLRFVQ
AINIGDPQALAETLTLWSAGESPPRERLLLAAEQLVARHGGTRLVLATLVNDFFALMRQERLTVPPDLLLIFKALVTLDG
VLANIAPGFDLTLALRQAAVRIVASRLDPAAWTPVLQGLLLEITRIGQDGPRLLRLIIERLERDQFIPPQRGGTEIAAAG
RWIAGAIVAGSLILAAALMLF
>Mature_501_residues
MLKSLMVAARDRERLGEVTGVLARYGLDTAIDRLGLGAKDLLAGEAAALPARTRLALEELGPTFVKLGQILATRSDLLPP
DWITELERLHSQAATLPFEMVRPAIEEALGEPVGKAFAAFDPEPLAAASMAQVHRAHLHDGRAIVLKVRRPGIRPRMEAD
LRLIAQFAAVLERASAEIRRFAPTALVQQLASAILEELDFTNEARNADRLRADLVGNAQVVIPGIHWEWTSETLLAMDYV
EGVAPRSAEALVQADIDPHAIASLGAQVVLDMVLLTGRFHADPHPGNLLCLPGNRLALLDLGLIGHVSPRRREELLRFVQ
AINIGDPQALAETLTLWSAGESPPRERLLLAAEQLVARHGGTRLVLATLVNDFFALMRQERLTVPPDLLLIFKALVTLDG
VLANIAPGFDLTLALRQAAVRIVASRLDPAAWTPVLQGLLLEITRIGQDGPRLLRLIIERLERDQFIPPQRGGTEIAAAG
RWIAGAIVAGSLILAAALMLF

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=295, Percent_Identity=32.2033898305085, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI41393593, Length=347, Percent_Identity=30.2593659942363, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI217035081, Length=331, Percent_Identity=28.3987915407855, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI34147522, Length=247, Percent_Identity=27.1255060728745, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI27363457, Length=272, Percent_Identity=25.3676470588235, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI217416386, Length=268, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=402, Percent_Identity=31.3432835820896, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17559152, Length=258, Percent_Identity=32.5581395348837, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=340, Percent_Identity=25.2941176470588, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323282, Length=281, Percent_Identity=26.3345195729537, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=250, Percent_Identity=26, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=255, Percent_Identity=25.4901960784314, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI22024280, Length=255, Percent_Identity=31.7647058823529, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=26.6025641025641, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18859849, Length=240, Percent_Identity=26.25, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54353; Mature: 54353

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSLMVAARDRERLGEVTGVLARYGLDTAIDRLGLGAKDLLAGEAAALPARTRLALEEL
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHCCCHHHCCHHHHHHHHHH
GPTFVKLGQILATRSDLLPPDWITELERLHSQAATLPFEMVRPAIEEALGEPVGKAFAAF
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCC
DPEPLAAASMAQVHRAHLHDGRAIVLKVRRPGIRPRMEADLRLIAQFAAVLERASAEIRR
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FAPTALVQQLASAILEELDFTNEARNADRLRADLVGNAQVVIPGIHWEWTSETLLAMDYV
HHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHH
EGVAPRSAEALVQADIDPHAIASLGAQVVLDMVLLTGRFHADPHPGNLLCLPGNRLALLD
HCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEE
LGLIGHVSPRRREELLRFVQAINIGDPQALAETLTLWSAGESPPRERLLLAAEQLVARHG
ECHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
GTRLVLATLVNDFFALMRQERLTVPPDLLLIFKALVTLDGVLANIAPGFDLTLALRQAAV
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RIVASRLDPAAWTPVLQGLLLEITRIGQDGPRLLRLIIERLERDQFIPPQRGGTEIAAAG
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCC
RWIAGAIVAGSLILAAALMLF
HHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLKSLMVAARDRERLGEVTGVLARYGLDTAIDRLGLGAKDLLAGEAAALPARTRLALEEL
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHCCCHHHCCHHHHHHHHHH
GPTFVKLGQILATRSDLLPPDWITELERLHSQAATLPFEMVRPAIEEALGEPVGKAFAAF
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCC
DPEPLAAASMAQVHRAHLHDGRAIVLKVRRPGIRPRMEADLRLIAQFAAVLERASAEIRR
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FAPTALVQQLASAILEELDFTNEARNADRLRADLVGNAQVVIPGIHWEWTSETLLAMDYV
HHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHH
EGVAPRSAEALVQADIDPHAIASLGAQVVLDMVLLTGRFHADPHPGNLLCLPGNRLALLD
HCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEE
LGLIGHVSPRRREELLRFVQAINIGDPQALAETLTLWSAGESPPRERLLLAAEQLVARHG
ECHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
GTRLVLATLVNDFFALMRQERLTVPPDLLLIFKALVTLDGVLANIAPGFDLTLALRQAAV
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RIVASRLDPAAWTPVLQGLLLEITRIGQDGPRLLRLIIERLERDQFIPPQRGGTEIAAAG
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCC
RWIAGAIVAGSLILAAALMLF
HHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA