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The map label for this gene is yjcE [H]

Identifier: 148550830

GI number: 148550830

Start: 301196

End: 302833

Strand: Direct

Name: yjcE [H]

Synonym: Swit_5394

Alternate gene names: 148550830

Gene position: 301196-302833 (Clockwise)

Preceding gene: 148550829

Following gene: 148550831

Centisome position: 97.09

GC content: 65.45

Gene sequence:

>1638_bases
TTGGAAGTCATCTCGATCGTCCTGCTTTTGCTGCTCGCGGTGATCCTGAGCGGTATTTTGTCCCGAATGCTGCCCCTGCC
CTTGCCCCGGCCGCTGTTTCAGATTGGACTTGGCGCGCTCATCGGGCTGGCCGCGGACTGGCGGGTCACGCTCGATCCCG
AGATCTTCTTCCTCCTCTTCCTGCCGCCGCTGCTCTTCCTGGATGGCTGGCGCATCCCGCGCGAGGAACTGTTCAAGGAC
GGCAAGACGATCGTCGAACTGGCCCTGGGCCTCGTGGTGGCGACGGTCGTGGGGATGGGCTTCTTCATCCACTGGATGAT
CCCGGCCATGCCGCTTGCCGTCGCCTTCGCGCTCGCGGCGGTCGTCTCGCCCACGGACCCAATCGCCGTTTCGGCGATTG
CGCAGCGTGTCCCCATTCCCAAGCGGATGATGCATATCCTGGAAGGGGAATCGCTGCTCAACGACGCCTCGGGCCTCGTC
TGCCTGCGCTTTGCCATCGCAGCCACGCTGACCGGCGCCTTTTCGCTCCACCAGGCCGCCATCAACTTCGTGTGGGTCGC
GCTGGGCGGGCTGGCCGTCGGTGCGGGCCTCACCTGGCTCGTCTCGCACGCCAAGAACTGGGTATCGCGGCGCTATGGCG
AGGAGGGCGGGGCGCAGATCCTCATCAGCCTGCTCCTGCCTTTCGGCTCCTATCTGGTTGCCGAACATCTGCACTGTTCG
GGCATCCTGGCCGCGGTGGCCGCAGGCCTTACGATGGGTTTCGTAGAAGGAAGCGGCGAACTTGCCGCCTCGACGCGCAT
CCGCCGCAACACGGTGTGGGACGTCATCCAGTTCACCGCCAATGGCGTCATCTTCGTCCTGCTCGGTGAACAGCTCCCGG
CCATTCTCGCAGGCGCGGCGGAGACGGTGCGCCTTACCGGTCACCATGAACCCTGGTGGCTCGGGGTCTATGTGCTTGCG
ATCAATCTTGGACTGGCCGCCTTGCGCTTCCTTTGGGTCTGGCTGTCGTTCCGCTTGAGCTTCTTCCGGCAGGGCGACGG
ACAATCGACCCCGAACTGGCGCATAGTCGCAGCGATGTCCTTTGCCGGCGTGCGCGGCGCTATCACGCTTGCGGGCGTGC
TCACGCTCCCGCTCGTGCTCAGCGATGGGTCACCCTTCCCGGGGCGGGACCTCGCCATTTTCCTGGCGATGGGCGTCATC
ATAGTCTCGCTCCTCGTCGCGAGCCTTGGCCTTCCCGTCCTGCTGCGGGGCCTGCTCATGCCGCCCGAGCATGACCAGCA
GAGCGCCGAAGATGCCGCGCGCGTCAAAGCGGCTGAAGCGGCTATTGCCCGGATCGAGGAGGTCCAGCACGAACTGGCCG
AGGGCCGCGCGGATGCCGATCTTTTTGTGTCAGCTGCGGCGCGGATCATGGACGGTTACCGCGAGCGGATCGAAAGCCGG
GTGGGGACACGCGAGGAAAATGCCGAGATGCGGCGAGGGGAGGCGATCGAGCGGCGCCTGCGCATCGCCGCGCTCAAAGC
GGAACGGAGCCAGATCTTTCGCATGGTCCGCAAACGGGAACTCGGCAGCGAGCTTGCGCGCAAGCTCATTCGGGAGCTTG
ATCTCGCAGAAGCCCGCCATGCGGCCCAGCTCGGCTGA

Upstream 100 bases:

>100_bases
GAAATCGATTGCCGCTACGAGGGCATCAAGGGCCTCGTTCTGCGCGCCGAATTCGTCCGCAAGCGCTGAGCCGGCCTGAC
GCCAAGATAGAGGAAACCTG

Downstream 100 bases:

>100_bases
CGGCGTGGACACAGGCAAGCACGGAGCCGGAAACAGAAAAGAAGGGAGCGGGCCATGGACGAGGCCGACCGGGAATGCAG
GGTCGACGAAGCGCTGCGCC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MEVISIVLLLLLAVILSGILSRMLPLPLPRPLFQIGLGALIGLAADWRVTLDPEIFFLLFLPPLLFLDGWRIPREELFKD
GKTIVELALGLVVATVVGMGFFIHWMIPAMPLAVAFALAAVVSPTDPIAVSAIAQRVPIPKRMMHILEGESLLNDASGLV
CLRFAIAATLTGAFSLHQAAINFVWVALGGLAVGAGLTWLVSHAKNWVSRRYGEEGGAQILISLLLPFGSYLVAEHLHCS
GILAAVAAGLTMGFVEGSGELAASTRIRRNTVWDVIQFTANGVIFVLLGEQLPAILAGAAETVRLTGHHEPWWLGVYVLA
INLGLAALRFLWVWLSFRLSFFRQGDGQSTPNWRIVAAMSFAGVRGAITLAGVLTLPLVLSDGSPFPGRDLAIFLAMGVI
IVSLLVASLGLPVLLRGLLMPPEHDQQSAEDAARVKAAEAAIARIEEVQHELAEGRADADLFVSAAARIMDGYRERIESR
VGTREENAEMRRGEAIERRLRIAALKAERSQIFRMVRKRELGSELARKLIRELDLAEARHAAQLG

Sequences:

>Translated_545_residues
MEVISIVLLLLLAVILSGILSRMLPLPLPRPLFQIGLGALIGLAADWRVTLDPEIFFLLFLPPLLFLDGWRIPREELFKD
GKTIVELALGLVVATVVGMGFFIHWMIPAMPLAVAFALAAVVSPTDPIAVSAIAQRVPIPKRMMHILEGESLLNDASGLV
CLRFAIAATLTGAFSLHQAAINFVWVALGGLAVGAGLTWLVSHAKNWVSRRYGEEGGAQILISLLLPFGSYLVAEHLHCS
GILAAVAAGLTMGFVEGSGELAASTRIRRNTVWDVIQFTANGVIFVLLGEQLPAILAGAAETVRLTGHHEPWWLGVYVLA
INLGLAALRFLWVWLSFRLSFFRQGDGQSTPNWRIVAAMSFAGVRGAITLAGVLTLPLVLSDGSPFPGRDLAIFLAMGVI
IVSLLVASLGLPVLLRGLLMPPEHDQQSAEDAARVKAAEAAIARIEEVQHELAEGRADADLFVSAAARIMDGYRERIESR
VGTREENAEMRRGEAIERRLRIAALKAERSQIFRMVRKRELGSELARKLIRELDLAEARHAAQLG
>Mature_545_residues
MEVISIVLLLLLAVILSGILSRMLPLPLPRPLFQIGLGALIGLAADWRVTLDPEIFFLLFLPPLLFLDGWRIPREELFKD
GKTIVELALGLVVATVVGMGFFIHWMIPAMPLAVAFALAAVVSPTDPIAVSAIAQRVPIPKRMMHILEGESLLNDASGLV
CLRFAIAATLTGAFSLHQAAINFVWVALGGLAVGAGLTWLVSHAKNWVSRRYGEEGGAQILISLLLPFGSYLVAEHLHCS
GILAAVAAGLTMGFVEGSGELAASTRIRRNTVWDVIQFTANGVIFVLLGEQLPAILAGAAETVRLTGHHEPWWLGVYVLA
INLGLAALRFLWVWLSFRLSFFRQGDGQSTPNWRIVAAMSFAGVRGAITLAGVLTLPLVLSDGSPFPGRDLAIFLAMGVI
IVSLLVASLGLPVLLRGLLMPPEHDQQSAEDAARVKAAEAAIARIEEVQHELAEGRADADLFVSAAARIMDGYRERIESR
VGTREENAEMRRGEAIERRLRIAALKAERSQIFRMVRKRELGSELARKLIRELDLAEARHAAQLG

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=382, Percent_Identity=24.869109947644, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI148727259, Length=467, Percent_Identity=23.7687366167024, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI41872703, Length=542, Percent_Identity=25.2767527675277, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI15529998, Length=440, Percent_Identity=24.7727272727273, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI110227626, Length=421, Percent_Identity=25.41567695962, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI14211919, Length=405, Percent_Identity=23.9506172839506, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI294997330, Length=421, Percent_Identity=25.41567695962, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI5454070, Length=420, Percent_Identity=25.4761904761905, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194239733, Length=427, Percent_Identity=24.1217798594848, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4759144, Length=423, Percent_Identity=26.0047281323877, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI27777632, Length=441, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790501, Length=546, Percent_Identity=42.1245421245421, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI25150332, Length=393, Percent_Identity=26.4631043256997, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71993590, Length=396, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=396, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71999819, Length=398, Percent_Identity=23.8693467336683, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=398, Percent_Identity=23.8693467336683, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=360, Percent_Identity=23.8888888888889, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=396, Percent_Identity=23.7373737373737, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71987537, Length=452, Percent_Identity=24.3362831858407, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71987535, Length=452, Percent_Identity=24.3362831858407, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=405, Percent_Identity=22.962962962963, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71990932, Length=404, Percent_Identity=23.2673267326733, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=259, Percent_Identity=25.4826254826255, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364513, Length=259, Percent_Identity=23.9382239382239, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221473215, Length=259, Percent_Identity=23.9382239382239, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221473222, Length=259, Percent_Identity=23.9382239382239, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221473212, Length=259, Percent_Identity=23.9382239382239, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221510738, Length=393, Percent_Identity=25.9541984732824, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281360447, Length=445, Percent_Identity=24.4943820224719, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221510734, Length=393, Percent_Identity=25.9541984732824, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221510732, Length=393, Percent_Identity=26.4631043256997, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221510736, Length=393, Percent_Identity=26.4631043256997, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585580, Length=393, Percent_Identity=26.4631043256997, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585578, Length=393, Percent_Identity=26.4631043256997, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221510740, Length=393, Percent_Identity=26.4631043256997, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59086; Mature: 59086

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVISIVLLLLLAVILSGILSRMLPLPLPRPLFQIGLGALIGLAADWRVTLDPEIFFLLF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHH
LPPLLFLDGWRIPREELFKDGKTIVELALGLVVATVVGMGFFIHWMIPAMPLAVAFALAA
HHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSPTDPIAVSAIAQRVPIPKRMMHILEGESLLNDASGLVCLRFAIAATLTGAFSLHQAA
HHCCCCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
INFVWVALGGLAVGAGLTWLVSHAKNWVSRRYGEEGGAQILISLLLPFGSYLVAEHLHCS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GILAAVAAGLTMGFVEGSGELAASTRIRRNTVWDVIQFTANGVIFVLLGEQLPAILAGAA
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCC
ETVRLTGHHEPWWLGVYVLAINLGLAALRFLWVWLSFRLSFFRQGDGQSTPNWRIVAAMS
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEH
FAGVRGAITLAGVLTLPLVLSDGSPFPGRDLAIFLAMGVIIVSLLVASLGLPVLLRGLLM
HHCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
PPEHDQQSAEDAARVKAAEAAIARIEEVQHELAEGRADADLFVSAAARIMDGYRERIESR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGTREENAEMRRGEAIERRLRIAALKAERSQIFRMVRKRELGSELARKLIRELDLAEARH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQLG
HHCCC
>Mature Secondary Structure
MEVISIVLLLLLAVILSGILSRMLPLPLPRPLFQIGLGALIGLAADWRVTLDPEIFFLLF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHH
LPPLLFLDGWRIPREELFKDGKTIVELALGLVVATVVGMGFFIHWMIPAMPLAVAFALAA
HHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSPTDPIAVSAIAQRVPIPKRMMHILEGESLLNDASGLVCLRFAIAATLTGAFSLHQAA
HHCCCCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
INFVWVALGGLAVGAGLTWLVSHAKNWVSRRYGEEGGAQILISLLLPFGSYLVAEHLHCS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GILAAVAAGLTMGFVEGSGELAASTRIRRNTVWDVIQFTANGVIFVLLGEQLPAILAGAA
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCC
ETVRLTGHHEPWWLGVYVLAINLGLAALRFLWVWLSFRLSFFRQGDGQSTPNWRIVAAMS
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEH
FAGVRGAITLAGVLTLPLVLSDGSPFPGRDLAIFLAMGVIIVSLLVASLGLPVLLRGLLM
HHCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
PPEHDQQSAEDAARVKAAEAAIARIEEVQHELAEGRADADLFVSAAARIMDGYRERIESR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGTREENAEMRRGEAIERRLRIAALKAERSQIFRMVRKRELGSELARKLIRELDLAEARH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQLG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]