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The map label for this gene is iscS [H]

Identifier: 148550762

GI number: 148550762

Start: 225066

End: 226229

Strand: Direct

Name: iscS [H]

Synonym: Swit_5326

Alternate gene names: 148550762

Gene position: 225066-226229 (Clockwise)

Preceding gene: 148550761

Following gene: 148550763

Centisome position: 72.55

GC content: 65.46

Gene sequence:

>1164_bases
ATGGCTGAGCGTGCGGCGCCTCTACACCCTCCGGTCTATCTGGATCACCATGCGAGCACACCCGTCGATCCCCGGGTGAT
CGAAGCGATGTGCGAAGCGATGCGCACGCTTCCTGCCAATCCCAACAGCGTCGAGCACGCGCTGGGCCGGCAGGCCGCGG
CGGCCATCGACGTCGCGCGTATCGAGGTCGCTTCGCTTGTCGGCGGGGAGGCGCAGGATATCCATTTTACCGCGTCGGCG
TCCGACGCAATCCGCAAGGCGCTGGAACTGGCGATCGCCCAGCGGGGGGAACTGCGGGTTGCAGCCATGCCGGTGGAACA
CCCCGCAATGATCCACGCACTGCGGGCGTTGGAGCGGCAGGGCTTGGCCACGGTGCATTGGTTGCAGGTCGATGCTTGCG
CGCAGCTTTGTCGCGCGAGCCTGGACGCAGCGCTGGCTGAGGGTCTGGACCTTGTGTGCATGATGGCTGCGAACAACGAG
GTGGGCACGGTCTATCCTGTAGAGGAGGTCCTGAATGCCTGTCTGGAAAACGGCGTCCTTACGCTGGTCGACGCGACGCA
AGCTGCTGGGCGCATCGATCTCCATCCTGTCACGCCCTTGGCGGACTATCTGGTCCTGAGCGGCCATAAGATCTACGGTC
CCAAGGGTATCGGCGTCCTGAACGCGCCTGGCTCAGGCGCCGCTGTCGCCGAGGTTTTTGCCCAGGCTGGCACGCCTAAT
GTTCCGGCGATCATAGGCCTTGGCGTCGCCTGCCGCATTGCCGGCGAGGAGCGGGTTGCGGAGTGCGCGCATGCCCAAAA
GCTTCGGGACCGGCTGGAAGCGGGTCTGCGGGCCTCGCTGGACCAGCTCGTGGTAAACGGCGATCTCCAGCGCCGCCTTC
CGCACAGCCTCCACGTGTCGATCCCGGGTGTCACCAACGATGCGATGCTCGCACGGGTGAGCCATCAGTTGGCCTTGTCG
ACAGGCGCAGCGTGCGCTTCGGGTGCCCAGGAGCCGTCCCATGTGCTGCGGTCGATGGGGCTTGGCGACGAGTTGGCGGA
TAGTGCCCTGCGGCTCTCGGTGGGCCGCTTCAATACCGAACAGGACGTCGATCGTGCCGTCCAGATTCTTGTCGGCGCGG
CTCGCGCCATTCTCAGTGCGCGCCAGGAGCACCATCTATGCTGA

Upstream 100 bases:

>100_bases
GACCGGTTGATCCGCTGGTTGGGCCGGCTCGGCCGGACGGTCGACGTCAAGGTAAAGGTGGCCGCGCCAGCCGGCGTGCC
GCCACGCGCGAGGCGTGCTC

Downstream 100 bases:

>100_bases
CCTCTGCCCGTCCCCATTATCGCTTTTCCGGGCATGAAAGCTTTGCCTGTCGCTATGCGTGGCTGCCCAAGGCCTACCGC
GCACTGCGCAACGATCCGTT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MAERAAPLHPPVYLDHHASTPVDPRVIEAMCEAMRTLPANPNSVEHALGRQAAAAIDVARIEVASLVGGEAQDIHFTASA
SDAIRKALELAIAQRGELRVAAMPVEHPAMIHALRALERQGLATVHWLQVDACAQLCRASLDAALAEGLDLVCMMAANNE
VGTVYPVEEVLNACLENGVLTLVDATQAAGRIDLHPVTPLADYLVLSGHKIYGPKGIGVLNAPGSGAAVAEVFAQAGTPN
VPAIIGLGVACRIAGEERVAECAHAQKLRDRLEAGLRASLDQLVVNGDLQRRLPHSLHVSIPGVTNDAMLARVSHQLALS
TGAACASGAQEPSHVLRSMGLGDELADSALRLSVGRFNTEQDVDRAVQILVGAARAILSARQEHHLC

Sequences:

>Translated_387_residues
MAERAAPLHPPVYLDHHASTPVDPRVIEAMCEAMRTLPANPNSVEHALGRQAAAAIDVARIEVASLVGGEAQDIHFTASA
SDAIRKALELAIAQRGELRVAAMPVEHPAMIHALRALERQGLATVHWLQVDACAQLCRASLDAALAEGLDLVCMMAANNE
VGTVYPVEEVLNACLENGVLTLVDATQAAGRIDLHPVTPLADYLVLSGHKIYGPKGIGVLNAPGSGAAVAEVFAQAGTPN
VPAIIGLGVACRIAGEERVAECAHAQKLRDRLEAGLRASLDQLVVNGDLQRRLPHSLHVSIPGVTNDAMLARVSHQLALS
TGAACASGAQEPSHVLRSMGLGDELADSALRLSVGRFNTEQDVDRAVQILVGAARAILSARQEHHLC
>Mature_386_residues
AERAAPLHPPVYLDHHASTPVDPRVIEAMCEAMRTLPANPNSVEHALGRQAAAAIDVARIEVASLVGGEAQDIHFTASAS
DAIRKALELAIAQRGELRVAAMPVEHPAMIHALRALERQGLATVHWLQVDACAQLCRASLDAALAEGLDLVCMMAANNEV
GTVYPVEEVLNACLENGVLTLVDATQAAGRIDLHPVTPLADYLVLSGHKIYGPKGIGVLNAPGSGAAVAEVFAQAGTPNV
PAIIGLGVACRIAGEERVAECAHAQKLRDRLEAGLRASLDQLVVNGDLQRRLPHSLHVSIPGVTNDAMLARVSHQLALST
GAACASGAQEPSHVLRSMGLGDELADSALRLSVGRFNTEQDVDRAVQILVGAARAILSARQEHHLC

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=379, Percent_Identity=34.8284960422164, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI156713448, Length=410, Percent_Identity=33.6585365853659, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI48994898, Length=376, Percent_Identity=36.7021276595745, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1787970, Length=281, Percent_Identity=27.4021352313167, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25143064, Length=385, Percent_Identity=32.7272727272727, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17533177, Length=316, Percent_Identity=26.8987341772152, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=369, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20129463, Length=365, Percent_Identity=33.1506849315069, Blast_Score=195, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40632; Mature: 40501

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERAAPLHPPVYLDHHASTPVDPRVIEAMCEAMRTLPANPNSVEHALGRQAAAAIDVAR
CCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IEVASLVGGEAQDIHFTASASDAIRKALELAIAQRGELRVAAMPVEHPAMIHALRALERQ
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHC
GLATVHWLQVDACAQLCRASLDAALAEGLDLVCMMAANNEVGTVYPVEEVLNACLENGVL
CCCEEEHEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHCCCE
TLVDATQAAGRIDLHPVTPLADYLVLSGHKIYGPKGIGVLNAPGSGAAVAEVFAQAGTPN
EEEECHHCCCEEECCCCCHHHHHHHHCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCCC
VPAIIGLGVACRIAGEERVAECAHAQKLRDRLEAGLRASLDQLVVNGDLQRRLPHSLHVS
CCHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEE
IPGVTNDAMLARVSHQLALSTGAACASGAQEPSHVLRSMGLGDELADSALRLSVGRFNTE
CCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCH
QDVDRAVQILVGAARAILSARQEHHLC
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AERAAPLHPPVYLDHHASTPVDPRVIEAMCEAMRTLPANPNSVEHALGRQAAAAIDVAR
CCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IEVASLVGGEAQDIHFTASASDAIRKALELAIAQRGELRVAAMPVEHPAMIHALRALERQ
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHC
GLATVHWLQVDACAQLCRASLDAALAEGLDLVCMMAANNEVGTVYPVEEVLNACLENGVL
CCCEEEHEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHCCCE
TLVDATQAAGRIDLHPVTPLADYLVLSGHKIYGPKGIGVLNAPGSGAAVAEVFAQAGTPN
EEEECHHCCCEEECCCCCHHHHHHHHCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCCC
VPAIIGLGVACRIAGEERVAECAHAQKLRDRLEAGLRASLDQLVVNGDLQRRLPHSLHVS
CCHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEE
IPGVTNDAMLARVSHQLALSTGAACASGAQEPSHVLRSMGLGDELADSALRLSVGRFNTE
CCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCH
QDVDRAVQILVGAARAILSARQEHHLC
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA