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The map label for this gene is zraS [C]

Identifier: 148550687

GI number: 148550687

Start: 141342

End: 143057

Strand: Direct

Name: zraS [C]

Synonym: Swit_5251

Alternate gene names: 148550687

Gene position: 141342-143057 (Clockwise)

Preceding gene: 148550686

Following gene: 148550688

Centisome position: 45.56

GC content: 66.55

Gene sequence:

>1716_bases
GTGCGCGATTGGCAACCTGCGGAAGTCGCGCTCATCGAGGAAGTGGCCGCGCGGGTGTGGGACGCAGTCGAGCGGGCCAA
TGCGGTCGACGACCTGCGCGCGCTCAATGCCGATCTGGAACGCCGGATCGCGGCGGCCGTGGCCGAGCGTGAGAAAGCCG
AAGAGGCCTTGCGGCAAAGCCAGAAGATGGAAGCGGTCGGCCAGCTCACCGGCGGGATCGCGCATGATTTCAACAATCTG
CTGACCATCGTCACTGGCAATATCGACATGGCCAGCCGGGCACTCGAGGCGGCGGGCGTCAACGATCCGCGCGCGCGCCG
CGCGCTCGACAATGCGATGAAGGGCGGCGAACGCGCGGCGGCGCTCACGCACCGGCTGCTCGCTTTCTCGCGCCGCCAGC
CGCTGGCGCCTAAGCCGACCGATGCCGATCGGCTGGTCGCGGGCATGTCTGATCTCCTCGGTCGTTCGCTGGGCGAGACG
GTCAGCCTCGAGATCGTTACCTCGCCGGGGCTCTGGCGGATCGAGGCCGACCAGAACCAGCTTGAAAATGCGATCCTCAA
TCTGGCCCTCAATGCGCGCGACGCGATGCCCCAGGGCGGAACGCTGACGATCGAGACGGCCAATGCCCGGCTGGGGGACG
AATATAGCGCGCAGCATGCCGAGGTGGCGCCTGGCCAATATGTGGTGATCGCGGTGACCGATACCGGTGAAGGTATGACC
CGCGAGACGCTGGCCCGGGTGTTCGAACCCTTTTTCACCACCAAGGAGGTGGGCCGCGGCACGGGCCTGGGACTCTCGCA
GGTCTACGGCTTCACCAAGCAGTCGGGCGGACATGTGAAGATTTATTCGGAGGAGAATCAGGGCACCACCGTCAAGATTT
ACCTGCCGCGCCTCGTTAGCGATGGCGAAGTGGAGCCGGCCGCGGAGCAGGTGACCGACCTGGAGACCAGCCCGCGCCGG
GAGACCATCCTTGCTGTCGAGGATGATGACGATGTACGCGCCTATACGGTCGAGTGCCTGCGCGAACTCGGTTACCGGGT
GCTCGAAGCCCATGACGGGCCCTCGGCGCTCGCGCTGATGGAGCGGCAGGGAACTTCGGTGGACCTGCTGTTCACCGATG
TGGTCATGCCCGGCATGTCGGGCCGCGAGCTCGCGGACGAGCTGCGGCGACGCCAGCCCGATCTGCGCGTGCTCTACACC
TCGGGCTATACGCGCAACGCCATCACCCATGGCGGACGGCTGGACGAAGGCGTGGAGATGATCGCCAAGCCTTTCACCTA
CCAGGCCTTGGCCATGAAATTGCGGGACATGCTAGAGGCTGGCCGCACCAAGCGCGTGCTGGTGGTCGACCACGATCCGA
TGGTGCGGGCGCTGGTGGCCGAATCCTTGGCCGGGGTCGACTATACCGCCGACGAAGCCGCGACGGCGGCCGAGGCCTTG
ATGACGGTCCGGGCGGCACAGGGGCGCTTCGATGCCGTGGTGCTGGATCTCGCACTCCCCGACAAGCCGGGCGACCTTGT
GGCGGCCGAATTGCGGGCGCTTCATGCCGATCTACCGATTCTGATCGCAGCGGACGCAGGCGCCGAGGCGCTCGCGGCGC
GGTTCGCCGAGGATCGCTGCATCGCCGTCATCGCCAAACCCTATACCGGCGGTCTGCTCAAGGAAGCGCTGGCCGATCTG
GGGATGCGATGCGCGGTCGGGGACACGGGGCAATAG

Upstream 100 bases:

>100_bases
CGGGCATCGGCCTCGCGGCCTTCGGGATCGCGAGCCTGGTCGCCGTGCCGCTGATCCGCGAGGGCGTATTGCGTGCCTCT
CTCTACGTCAATAGGACGAG

Downstream 100 bases:

>100_bases
GACGCGGAGAAAAGGGCGGCTGCTCTTGTCGGGCAGCGCTCGGGAGACGCCGCAGGCGATAGGCGCGTTCGATGGCGGCG
ACGGCGTGGCCGGCCAGCAA

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MRDWQPAEVALIEEVAARVWDAVERANAVDDLRALNADLERRIAAAVAEREKAEEALRQSQKMEAVGQLTGGIAHDFNNL
LTIVTGNIDMASRALEAAGVNDPRARRALDNAMKGGERAAALTHRLLAFSRRQPLAPKPTDADRLVAGMSDLLGRSLGET
VSLEIVTSPGLWRIEADQNQLENAILNLALNARDAMPQGGTLTIETANARLGDEYSAQHAEVAPGQYVVIAVTDTGEGMT
RETLARVFEPFFTTKEVGRGTGLGLSQVYGFTKQSGGHVKIYSEENQGTTVKIYLPRLVSDGEVEPAAEQVTDLETSPRR
ETILAVEDDDDVRAYTVECLRELGYRVLEAHDGPSALALMERQGTSVDLLFTDVVMPGMSGRELADELRRRQPDLRVLYT
SGYTRNAITHGGRLDEGVEMIAKPFTYQALAMKLRDMLEAGRTKRVLVVDHDPMVRALVAESLAGVDYTADEAATAAEAL
MTVRAAQGRFDAVVLDLALPDKPGDLVAAELRALHADLPILIAADAGAEALAARFAEDRCIAVIAKPYTGGLLKEALADL
GMRCAVGDTGQ

Sequences:

>Translated_571_residues
MRDWQPAEVALIEEVAARVWDAVERANAVDDLRALNADLERRIAAAVAEREKAEEALRQSQKMEAVGQLTGGIAHDFNNL
LTIVTGNIDMASRALEAAGVNDPRARRALDNAMKGGERAAALTHRLLAFSRRQPLAPKPTDADRLVAGMSDLLGRSLGET
VSLEIVTSPGLWRIEADQNQLENAILNLALNARDAMPQGGTLTIETANARLGDEYSAQHAEVAPGQYVVIAVTDTGEGMT
RETLARVFEPFFTTKEVGRGTGLGLSQVYGFTKQSGGHVKIYSEENQGTTVKIYLPRLVSDGEVEPAAEQVTDLETSPRR
ETILAVEDDDDVRAYTVECLRELGYRVLEAHDGPSALALMERQGTSVDLLFTDVVMPGMSGRELADELRRRQPDLRVLYT
SGYTRNAITHGGRLDEGVEMIAKPFTYQALAMKLRDMLEAGRTKRVLVVDHDPMVRALVAESLAGVDYTADEAATAAEAL
MTVRAAQGRFDAVVLDLALPDKPGDLVAAELRALHADLPILIAADAGAEALAARFAEDRCIAVIAKPYTGGLLKEALADL
GMRCAVGDTGQ
>Mature_571_residues
MRDWQPAEVALIEEVAARVWDAVERANAVDDLRALNADLERRIAAAVAEREKAEEALRQSQKMEAVGQLTGGIAHDFNNL
LTIVTGNIDMASRALEAAGVNDPRARRALDNAMKGGERAAALTHRLLAFSRRQPLAPKPTDADRLVAGMSDLLGRSLGET
VSLEIVTSPGLWRIEADQNQLENAILNLALNARDAMPQGGTLTIETANARLGDEYSAQHAEVAPGQYVVIAVTDTGEGMT
RETLARVFEPFFTTKEVGRGTGLGLSQVYGFTKQSGGHVKIYSEENQGTTVKIYLPRLVSDGEVEPAAEQVTDLETSPRR
ETILAVEDDDDVRAYTVECLRELGYRVLEAHDGPSALALMERQGTSVDLLFTDVVMPGMSGRELADELRRRQPDLRVLYT
SGYTRNAITHGGRLDEGVEMIAKPFTYQALAMKLRDMLEAGRTKRVLVVDHDPMVRALVAESLAGVDYTADEAATAAEAL
MTVRAAQGRFDAVVLDLALPDKPGDLVAAELRALHADLPILIAADAGAEALAARFAEDRCIAVIAKPYTGGLLKEALADL
GMRCAVGDTGQ

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=27.8225806451613, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788713, Length=461, Percent_Identity=25.3796095444685, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=257, Percent_Identity=26.0700389105058, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61632; Mature: 61632

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDWQPAEVALIEEVAARVWDAVERANAVDDLRALNADLERRIAAAVAEREKAEEALRQS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKMEAVGQLTGGIAHDFNNLLTIVTGNIDMASRALEAAGVNDPRARRALDNAMKGGERAA
HHHHHHHHHHCHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHH
ALTHRLLAFSRRQPLAPKPTDADRLVAGMSDLLGRSLGETVSLEIVTSPGLWRIEADQNQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCHHH
LENAILNLALNARDAMPQGGTLTIETANARLGDEYSAQHAEVAPGQYVVIAVTDTGEGMT
HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
RETLARVFEPFFTTKEVGRGTGLGLSQVYGFTKQSGGHVKIYSEENQGTTVKIYLPRLVS
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCC
DGEVEPAAEQVTDLETSPRRETILAVEDDDDVRAYTVECLRELGYRVLEAHDGPSALALM
CCCCCHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCHHHHHCCCCCHHHHHH
ERQGTSVDLLFTDVVMPGMSGRELADELRRRQPDLRVLYTSGYTRNAITHGGRLDEGVEM
HCCCCEEEEEEEHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHH
IAKPFTYQALAMKLRDMLEAGRTKRVLVVDHDPMVRALVAESLAGVDYTADEAATAAEAL
HHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MTVRAAQGRFDAVVLDLALPDKPGDLVAAELRALHADLPILIAADAGAEALAARFAEDRC
HHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCE
IAVIAKPYTGGLLKEALADLGMRCAVGDTGQ
EEEEECCCCCHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MRDWQPAEVALIEEVAARVWDAVERANAVDDLRALNADLERRIAAAVAEREKAEEALRQS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKMEAVGQLTGGIAHDFNNLLTIVTGNIDMASRALEAAGVNDPRARRALDNAMKGGERAA
HHHHHHHHHHCHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHH
ALTHRLLAFSRRQPLAPKPTDADRLVAGMSDLLGRSLGETVSLEIVTSPGLWRIEADQNQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCHHH
LENAILNLALNARDAMPQGGTLTIETANARLGDEYSAQHAEVAPGQYVVIAVTDTGEGMT
HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
RETLARVFEPFFTTKEVGRGTGLGLSQVYGFTKQSGGHVKIYSEENQGTTVKIYLPRLVS
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCC
DGEVEPAAEQVTDLETSPRRETILAVEDDDDVRAYTVECLRELGYRVLEAHDGPSALALM
CCCCCHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCHHHHHCCCCCHHHHHH
ERQGTSVDLLFTDVVMPGMSGRELADELRRRQPDLRVLYTSGYTRNAITHGGRLDEGVEM
HCCCCEEEEEEEHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHH
IAKPFTYQALAMKLRDMLEAGRTKRVLVVDHDPMVRALVAESLAGVDYTADEAATAAEAL
HHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MTVRAAQGRFDAVVLDLALPDKPGDLVAAELRALHADLPILIAADAGAEALAARFAEDRC
HHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCE
IAVIAKPYTGGLLKEALADLGMRCAVGDTGQ
EEEEECCCCCHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA