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The map label for this gene is kefBC [H]

Identifier: 148550651

GI number: 148550651

Start: 104722

End: 106431

Strand: Direct

Name: kefBC [H]

Synonym: Swit_5214

Alternate gene names: 148550651

Gene position: 104722-106431 (Clockwise)

Preceding gene: 148550650

Following gene: 148550652

Centisome position: 33.76

GC content: 64.21

Gene sequence:

>1710_bases
ATGGAAGAACAGCTTGCTCAGACATTCCTTCTGATCGCGGCTGCATTTGTGGCAGTTGCCATCCTGGCGAGGCTCCGCCT
GTCGCCGGTGTTGGGCTATCTCGCCGCCGGCCTGCTCCTGGGCCCCCATGGCATAGGCGCAGTAACCGACAGCGAAGGCA
CCCATTTTTTCGGCGAGCTCGGCATCGCTCTCCTCATGTTCGTGATTGGCCTTGAATTTTCCGTGCCTCGGCTGCTGTCC
AGCGGGGGCGCCATGATCGGGCTCGGGTTCGGAACCGTGGCAGGCGCAACACTGCTGGCGGGAGCTGCGAGCCATTTCCT
CGTAGGATTGCCGCTTCTGCCAGCGGCCCTCCTGGGCGGCGCCATCGCCATGTCATCGACCGCCATCATCCAAAAGCATC
TCGTCGACACCGACGCGGTATCGAGCCGCCACGGCGTGGCTGCGACCGGCATAGTCCTGTTTGAGGACCTGGTCGCTTTG
ATCCTGCTGTCGCTCATTGCTGCCCTTCCAGACGCGGCCAACGAGGTCGAGATGGAAAAGGTACTGCTGCGCATGGGTGT
CAGCTTCGTGGCATTGGCGGGCGTGGCGCTTCTCGCACGGCGCACGCTTGGCCGTTTGCTCGGGTGGGTCGCGAGATCCG
GCCCGGACGAAACCTTCCTGCTGGGCGTGCTGACGCTTGTTGTGGGCGCGTCGCTTGCAGCGGAAAAGATCGGACTGTCG
CTTCCTATCGGCGCCTTCGTAGTCGGGATGATGGTCGGCGAAAGTGACTTCAGGCACCAGCTCGAAGAGGAAATCCGGCC
ATTTCGCGATCTGCTGCTGGGCGTCTTCTTCGTGACGATCGGCATGTCGGTCGACTGGTCGCAGATCCTGGCCCAGCCGG
CTGTCACCTTTCTCGTTCTGGCCGCGATCCTTGTCGTCAAGTTCCTGGTCGTCTTTGGCGTCACCCGTCTCTCAGGCCTC
CCGGCAAGCAGCGCGGTCAAGACCGGCTTGCTTCTGGCGCATTCGGGTGAGCTTGGGCTACTCATCGTGGGTCGGTCGCT
CGATAGCGCCCTTCTGTCGCCCGCGATCGGCCAGCCCGTCCTGGGCGCGATCGCCGCGAGCATGCTCGTCGGACCGATCC
TGGCGCAGTGGAGCGACCGGGCCGGAGATCTCATCCTGCGGAGCCGGGATCCGCGCGGCGCGGAGATCGAAACAGCGGTT
CGCACAACATCTCAGGAGCTCAAGGGTCACGTCGTGCTTGCCGGCTGCGGCCCCGTGGGCCGTCTGGTCGCGCTCACACT
CGAGGCGAGCGAAATTCCATACCTGGCGATCGAGCGAAACGTGGAGCGCCTTCGCCGCGCCCAACAGGACGGTCATAAAG
CGGTTTTCGGCGACGCCAGCCGAGCGGGAATACTCAAGGCAGCCGGCGTCGATCGCGCCGCAGCCATCATCGTGCTTGTC
AACAATTGGCATCGGTCGGTGCGCATCATTCGCGAAGCCAAGCGCCTGAACCCCGCGATCCATGTGATCGCCAGCCTCCG
CGACGATGCGCATCTGGGTGAGCTGGCGCAGGCGGGCGCGGCACATGTCTTTCCCGAAAACTATGCTGCGGGGCTTGGGC
TCGGCGCTCAGGCCCTGATGACGCTCGGCATGTCTGCGGACGATGCGACCGATAGGATCCGGGCTATGCGGGCGCAGCTC
AGTCCGGACCTTCAGATCGTGCCGCGGTGA

Upstream 100 bases:

>100_bases
GTCTTTAGGTCGGGTGGCTGGCATCAACCGATGACATCTCCCTCTTTCATCCTACATCACGCCCAAATCCAACTAGCGAC
TGGATAAGGCTCTTGAATTC

Downstream 100 bases:

>100_bases
GTTGCCAGCCCGACCAACCACACTCAAACTAAATCATTACGACACCAACATAAAATGTGGAGATAGGCGAGCGGATGACT
TACCTTGGATGCAGTGACAA

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MEEQLAQTFLLIAAAFVAVAILARLRLSPVLGYLAAGLLLGPHGIGAVTDSEGTHFFGELGIALLMFVIGLEFSVPRLLS
SGGAMIGLGFGTVAGATLLAGAASHFLVGLPLLPAALLGGAIAMSSTAIIQKHLVDTDAVSSRHGVAATGIVLFEDLVAL
ILLSLIAALPDAANEVEMEKVLLRMGVSFVALAGVALLARRTLGRLLGWVARSGPDETFLLGVLTLVVGASLAAEKIGLS
LPIGAFVVGMMVGESDFRHQLEEEIRPFRDLLLGVFFVTIGMSVDWSQILAQPAVTFLVLAAILVVKFLVVFGVTRLSGL
PASSAVKTGLLLAHSGELGLLIVGRSLDSALLSPAIGQPVLGAIAASMLVGPILAQWSDRAGDLILRSRDPRGAEIETAV
RTTSQELKGHVVLAGCGPVGRLVALTLEASEIPYLAIERNVERLRRAQQDGHKAVFGDASRAGILKAAGVDRAAAIIVLV
NNWHRSVRIIREAKRLNPAIHVIASLRDDAHLGELAQAGAAHVFPENYAAGLGLGAQALMTLGMSADDATDRIRAMRAQL
SPDLQIVPR

Sequences:

>Translated_569_residues
MEEQLAQTFLLIAAAFVAVAILARLRLSPVLGYLAAGLLLGPHGIGAVTDSEGTHFFGELGIALLMFVIGLEFSVPRLLS
SGGAMIGLGFGTVAGATLLAGAASHFLVGLPLLPAALLGGAIAMSSTAIIQKHLVDTDAVSSRHGVAATGIVLFEDLVAL
ILLSLIAALPDAANEVEMEKVLLRMGVSFVALAGVALLARRTLGRLLGWVARSGPDETFLLGVLTLVVGASLAAEKIGLS
LPIGAFVVGMMVGESDFRHQLEEEIRPFRDLLLGVFFVTIGMSVDWSQILAQPAVTFLVLAAILVVKFLVVFGVTRLSGL
PASSAVKTGLLLAHSGELGLLIVGRSLDSALLSPAIGQPVLGAIAASMLVGPILAQWSDRAGDLILRSRDPRGAEIETAV
RTTSQELKGHVVLAGCGPVGRLVALTLEASEIPYLAIERNVERLRRAQQDGHKAVFGDASRAGILKAAGVDRAAAIIVLV
NNWHRSVRIIREAKRLNPAIHVIASLRDDAHLGELAQAGAAHVFPENYAAGLGLGAQALMTLGMSADDATDRIRAMRAQL
SPDLQIVPR
>Mature_569_residues
MEEQLAQTFLLIAAAFVAVAILARLRLSPVLGYLAAGLLLGPHGIGAVTDSEGTHFFGELGIALLMFVIGLEFSVPRLLS
SGGAMIGLGFGTVAGATLLAGAASHFLVGLPLLPAALLGGAIAMSSTAIIQKHLVDTDAVSSRHGVAATGIVLFEDLVAL
ILLSLIAALPDAANEVEMEKVLLRMGVSFVALAGVALLARRTLGRLLGWVARSGPDETFLLGVLTLVVGASLAAEKIGLS
LPIGAFVVGMMVGESDFRHQLEEEIRPFRDLLLGVFFVTIGMSVDWSQILAQPAVTFLVLAAILVVKFLVVFGVTRLSGL
PASSAVKTGLLLAHSGELGLLIVGRSLDSALLSPAIGQPVLGAIAASMLVGPILAQWSDRAGDLILRSRDPRGAEIETAV
RTTSQELKGHVVLAGCGPVGRLVALTLEASEIPYLAIERNVERLRRAQQDGHKAVFGDASRAGILKAAGVDRAAAIIVLV
NNWHRSVRIIREAKRLNPAIHVIASLRDDAHLGELAQAGAAHVFPENYAAGLGLGAQALMTLGMSADDATDRIRAMRAQL
SPDLQIVPR

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=383, Percent_Identity=24.5430809399478, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1786232, Length=566, Percent_Identity=30.2120141342756, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1789749, Length=555, Percent_Identity=29.1891891891892, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1786685, Length=522, Percent_Identity=30.2681992337165, Blast_Score=182, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 59337; Mature: 59337

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQLAQTFLLIAAAFVAVAILARLRLSPVLGYLAAGLLLGPHGIGAVTDSEGTHFFGEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
GIALLMFVIGLEFSVPRLLSSGGAMIGLGFGTVAGATLLAGAASHFLVGLPLLPAALLGG
HHHHHHHHHHCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAMSSTAIIQKHLVDTDAVSSRHGVAATGIVLFEDLVALILLSLIAALPDAANEVEMEK
HHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
VLLRMGVSFVALAGVALLARRTLGRLLGWVARSGPDETFLLGVLTLVVGASLAAEKIGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LPIGAFVVGMMVGESDFRHQLEEEIRPFRDLLLGVFFVTIGMSVDWSQILAQPAVTFLVL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AAILVVKFLVVFGVTRLSGLPASSAVKTGLLLAHSGELGLLIVGRSLDSALLSPAIGQPV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEEEECCCEEEEEECCCHHHHHHCCCCCCHH
LGAIAASMLVGPILAQWSDRAGDLILRSRDPRGAEIETAVRTTSQELKGHVVLAGCGPVG
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHH
RLVALTLEASEIPYLAIERNVERLRRAQQDGHKAVFGDASRAGILKAAGVDRAAAIIVLV
HHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCEEEEEEE
NNWHRSVRIIREAKRLNPAIHVIASLRDDAHLGELAQAGAAHVFPENYAAGLGLGAQALM
CCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHH
TLGMSADDATDRIRAMRAQLSPDLQIVPR
HHCCCCCCHHHHHHHHHHHCCCCCEECCC
>Mature Secondary Structure
MEEQLAQTFLLIAAAFVAVAILARLRLSPVLGYLAAGLLLGPHGIGAVTDSEGTHFFGEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
GIALLMFVIGLEFSVPRLLSSGGAMIGLGFGTVAGATLLAGAASHFLVGLPLLPAALLGG
HHHHHHHHHHCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAMSSTAIIQKHLVDTDAVSSRHGVAATGIVLFEDLVALILLSLIAALPDAANEVEMEK
HHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
VLLRMGVSFVALAGVALLARRTLGRLLGWVARSGPDETFLLGVLTLVVGASLAAEKIGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LPIGAFVVGMMVGESDFRHQLEEEIRPFRDLLLGVFFVTIGMSVDWSQILAQPAVTFLVL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AAILVVKFLVVFGVTRLSGLPASSAVKTGLLLAHSGELGLLIVGRSLDSALLSPAIGQPV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEEEECCCEEEEEECCCHHHHHHCCCCCCHH
LGAIAASMLVGPILAQWSDRAGDLILRSRDPRGAEIETAVRTTSQELKGHVVLAGCGPVG
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHH
RLVALTLEASEIPYLAIERNVERLRRAQQDGHKAVFGDASRAGILKAAGVDRAAAIIVLV
HHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCEEEEEEE
NNWHRSVRIIREAKRLNPAIHVIASLRDDAHLGELAQAGAAHVFPENYAAGLGLGAQALM
CCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHH
TLGMSADDATDRIRAMRAQLSPDLQIVPR
HHCCCCCCHHHHHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]