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The map label for this gene is pdhA [H]

Identifier: 148550593

GI number: 148550593

Start: 47425

End: 48507

Strand: Reverse

Name: pdhA [H]

Synonym: Swit_5154

Alternate gene names: 148550593

Gene position: 48507-47425 (Counterclockwise)

Preceding gene: 148550595

Following gene: 148550592

Centisome position: 15.64

GC content: 63.34

Gene sequence:

>1083_bases
GTGGCCAAAGAGCAGCATGTGAAGGCAGAGAGCCGAGCCGGGCCGGCAAGGCGGGCTTCGGTTTCATCTGGATCCGCCTC
CAATCGCGAACGTCCGGCCGAGCCCGTCCGCTATCAGGCGACCAATGCGGAGATGCTGGAACTCTACCGCCAGATGCTGC
TGATCCGCCGTTTCGAGGAAAAGGCCGGCCAGCTTTACGGCTTCGGCATGATCGGCGGCTTCTGCCATCTTTATATCGGG
CAGGAGGCCGTCGCCGTCGGCCTGCAATCGGCTATGAGGGTGGGCAAGGACAGCGTCATCACCGGCTATCGCGACCACGG
CCACATGCTGGCCTACGGGATCGATCCCAAGGTCATCATGGCAGAGCTGACCGGCCGCGCTGCGGGCATTTCACGCGGCA
AGGGCGGGTCGATGCACATGTTCTCGGTCGATCATGGCTTCTATGGCGGCCACGGCATCGTCGGCGCGCAGGTGGGGCTG
GGCACGGGCCTAGCCTTCAAGCATAAATATGCGGATGATGGCGGCGTCTGCCTCACCTATTTCGGCGACGGCGCGGCCAA
TCAGGGACAGGTCTACGAAAGCTTCAACATGGCGGAGCTGTGGAAGCTGCCGGTGATTTTCGTGATCGAGAACAACCAGT
ACGCCATGGGAACCAGCGTCAACCGCGCGTCGGCCGAGGACCAACTCTATCGGCGCGGCGAGAGCTTCCGCATCCCCGGC
ATCCAGGTGGACGGCATGGACGTGCTCGCTGTCCGTGGCGCTGCTGAGGAAGCCCGGCAGTGGGTGCTGTCCGGCAAGGG
GCCGATCCTCCTGGAATTGAAGACCTACCGCTATCGGGGCCATTCCATGTCCGATCCGGCCAAGTACCGCTCGCGCGAGG
AAGTGCAGGCGGTCCGCGACAAGTCCGATGCCATCGAGCATCTCAAGCAGGAGTTGGAGGCGGCCGGCGTCACCGAGGAT
GAGTTGAAGGCGCTGGAGAAGGAGATCCGCCAGATCGTTCAGGAAGCCGCCGACTTCGCCGAGCAGGCCCCGGAGCCCGA
GCTTGCCGAACTCTATACCGATGTGCTGGTGGGGCAATATTGA

Upstream 100 bases:

>100_bases
TGGTTATACATACATCGAATGAACTATGATTTGAACTGATGTGACATTTATCTCATGGCCAGACCCCGAAAGCGCAGCAG
GCAGGGGAAGGGAAGGGTTC

Downstream 100 bases:

>100_bases
TGGCGATTGAACTGAAGATGCCGGCGCTTTCTCCCACCATGGAGGAGGGTACGCTCGCAAAGTGGCTCGTCAAGGAAGGC
GATGCGGTGAAATCCGGCGA

Product: pyruvate dehydrogenase (acetyl-transferring)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MAKEQHVKAESRAGPARRASVSSGSASNRERPAEPVRYQATNAEMLELYRQMLLIRRFEEKAGQLYGFGMIGGFCHLYIG
QEAVAVGLQSAMRVGKDSVITGYRDHGHMLAYGIDPKVIMAELTGRAAGISRGKGGSMHMFSVDHGFYGGHGIVGAQVGL
GTGLAFKHKYADDGGVCLTYFGDGAANQGQVYESFNMAELWKLPVIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPG
IQVDGMDVLAVRGAAEEARQWVLSGKGPILLELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDAIEHLKQELEAAGVTED
ELKALEKEIRQIVQEAADFAEQAPEPELAELYTDVLVGQY

Sequences:

>Translated_360_residues
MAKEQHVKAESRAGPARRASVSSGSASNRERPAEPVRYQATNAEMLELYRQMLLIRRFEEKAGQLYGFGMIGGFCHLYIG
QEAVAVGLQSAMRVGKDSVITGYRDHGHMLAYGIDPKVIMAELTGRAAGISRGKGGSMHMFSVDHGFYGGHGIVGAQVGL
GTGLAFKHKYADDGGVCLTYFGDGAANQGQVYESFNMAELWKLPVIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPG
IQVDGMDVLAVRGAAEEARQWVLSGKGPILLELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDAIEHLKQELEAAGVTED
ELKALEKEIRQIVQEAADFAEQAPEPELAELYTDVLVGQY
>Mature_359_residues
AKEQHVKAESRAGPARRASVSSGSASNRERPAEPVRYQATNAEMLELYRQMLLIRRFEEKAGQLYGFGMIGGFCHLYIGQ
EAVAVGLQSAMRVGKDSVITGYRDHGHMLAYGIDPKVIMAELTGRAAGISRGKGGSMHMFSVDHGFYGGHGIVGAQVGLG
TGLAFKHKYADDGGVCLTYFGDGAANQGQVYESFNMAELWKLPVIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPGI
QVDGMDVLAVRGAAEEARQWVLSGKGPILLELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDAIEHLKQELEAAGVTEDE
LKALEKEIRQIVQEAADFAEQAPEPELAELYTDVLVGQY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=352, Percent_Identity=51.1363636363636, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI4505685, Length=351, Percent_Identity=50.4273504273504, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI291084742, Length=319, Percent_Identity=53.2915360501567, Blast_Score=310, Evalue=9e-85,
Organism=Homo sapiens, GI291084744, Length=358, Percent_Identity=49.4413407821229, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI291084757, Length=351, Percent_Identity=45.2991452991453, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI11386135, Length=314, Percent_Identity=31.2101910828025, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI258645172, Length=314, Percent_Identity=31.2101910828025, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17536047, Length=315, Percent_Identity=52.0634920634921, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI32564172, Length=315, Percent_Identity=52.0634920634921, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI86563357, Length=353, Percent_Identity=28.328611898017, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI86563355, Length=353, Percent_Identity=28.328611898017, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=326, Percent_Identity=51.5337423312883, Blast_Score=337, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24639744, Length=328, Percent_Identity=53.0487804878049, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI28571106, Length=328, Percent_Identity=53.0487804878049, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24639740, Length=328, Percent_Identity=53.0487804878049, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=54.2483660130719, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24639748, Length=314, Percent_Identity=54.140127388535, Blast_Score=307, Evalue=7e-84,
Organism=Drosophila melanogaster, GI21355903, Length=313, Percent_Identity=27.1565495207668, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39548; Mature: 39417

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEQHVKAESRAGPARRASVSSGSASNRERPAEPVRYQATNAEMLELYRQMLLIRRFEE
CCCCHHCCHHHCCCCCHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
KAGQLYGFGMIGGFCHLYIGQEAVAVGLQSAMRVGKDSVITGYRDHGHMLAYGIDPKVIM
HHCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCCEEE
AELTGRAAGISRGKGGSMHMFSVDHGFYGGHGIVGAQVGLGTGLAFKHKYADDGGVCLTY
EECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEE
FGDGAANQGQVYESFNMAELWKLPVIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPG
ECCCCCCCCCHHHCCCHHHHHCCCEEEEEECCCEEECCCCCCCCHHHHHHHCCCCEECCC
IQVDGMDVLAVRGAAEEARQWVLSGKGPILLELKTYRYRGHSMSDPAKYRSREEVQAVRD
EEECCCEEEEECCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHH
KSDAIEHLKQELEAAGVTEDELKALEKEIRQIVQEAADFAEQAPEPELAELYTDVLVGQY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKEQHVKAESRAGPARRASVSSGSASNRERPAEPVRYQATNAEMLELYRQMLLIRRFEE
CCCHHCCHHHCCCCCHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
KAGQLYGFGMIGGFCHLYIGQEAVAVGLQSAMRVGKDSVITGYRDHGHMLAYGIDPKVIM
HHCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCCEEE
AELTGRAAGISRGKGGSMHMFSVDHGFYGGHGIVGAQVGLGTGLAFKHKYADDGGVCLTY
EECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEE
FGDGAANQGQVYESFNMAELWKLPVIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPG
ECCCCCCCCCHHHCCCHHHHHCCCEEEEEECCCEEECCCCCCCCHHHHHHHCCCCEECCC
IQVDGMDVLAVRGAAEEARQWVLSGKGPILLELKTYRYRGHSMSDPAKYRSREEVQAVRD
EEECCCEEEEECCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHH
KSDAIEHLKQELEAAGVTEDELKALEKEIRQIVQEAADFAEQAPEPELAELYTDVLVGQY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]