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The map label for this gene is mepA [H]

Identifier: 148380740

GI number: 148380740

Start: 2941209

End: 2942630

Strand: Reverse

Name: mepA [H]

Synonym: CBO2780

Alternate gene names: 148380740

Gene position: 2942630-2941209 (Counterclockwise)

Preceding gene: 148380741

Following gene: 148380739

Centisome position: 75.71

GC content: 29.89

Gene sequence:

>1422_bases
ATGGGAATTGACTACAAGTTATTTTCAAAAGAAAAGGTAGAAAAAGCTTTATTAAAATTTGCAGTTCCAGCTATGATTTC
TTTATTAGTTATGGAATTATATAATATGGTAGATACATTTTTCGTAGGTTTAGCTATAGGGCCGAAAGCCATAGGAGCAT
TAACCATAGCCTTTCCAGTACAAAGACTTATGTCTTCACTGGGGATGATGATAGCAGTGGGTGCATCTACTGCAGTAGCC
AGAAGTTTAGGTAAAAAAGATTATGATAACCTAAAATCGGTAATATTAAACGCTATAAATATTACTGTAGTTATAATGGT
AGTTTTAACTTTTATAATTTCAATCTTTAAAAAAGATATGATCACAGGCCTATTAGGTGCTAGTCAATCTATTTATCCTT
ATGCCAAAGAATACATTTCTATAGTAGTACTTGGTGGACTATTTCAGGCCCTAACTTTAGTTATTTGTTATATAATGACA
TCCTTAGGTTATACAAATATAACATTAAAAGCTACTTCGGTAGGAGCTATATTAAATGTTATAATTGACTATTTCTTAGT
TATGCATTTAAACTTTGGAGTAGCAGGAGCAGCTATAGCAACTGTGTTTTCACAAACAGTGGCATTAGTATATGCGATAT
ATAAATTTAATAAGGTTAGAAAGAAGATAGGATTAAATTTAAAATTAAATTTTGAACTTAAATTAGATATATTAAAGCCA
ATTTTAGCAGTAGGATTTTCAACCTTTATTATAGAAATATCTGATGCAGTGGTGGCAGTAATATTAAACAATATACTTTC
TATTTATGGAGGAGATAAGGCGTTGGTTATAGTAGGGGTAACTACCAAAATATCAATGTTCTTATTCATAACAGTTATAG
GCATAAGTTCGGCAATGCAACCTATAGCAGCATTTAACTATGGTGCAAAAAATTTAGTTCGTGTAAAGGAAGTAGTTATA
AAGACTATAGTAGCTGTAACAGGAGCAACTTTAATATTATGGGCAGTAATGCTTATATTTGCAAATCCTATAATAGGATT
ATTTTTAAAGGATAGAAGTCTTTTAGGTGAAACTGTAAAAGCCTTTAGAATAATAATATCTCTATTTCCAACCATAGGGA
TATATTATGTATCCATATATTATTACCAATCTATGGGAAAGGCAAGAACTTCACTTATACTATCTGTATATAGGCAAATG
ATAATATTTATACCATTATTATTTATATTAGTTGGTAAATTTGATATCATGGGAGCTTGGATAGCTTATCCAATTTCAGA
TTTAATATCAGCTATTACAGGAGTAATATATGTAAGAGTAGCATTAAAAGAAAAAAACAAAGCTATAGAAGCTCAAGAAT
ATGAAAAAGAGAAAAAAGATAAAGCATTCAAAGGAAGATCCGTAGAAGTAGGTGGCCTTTAA

Upstream 100 bases:

>100_bases
TTTATATAAGATTATAATTTTAAAAAGAAGGAGTAGATAACAAAATGAGTGCAAAAATGTTACCTAAAAATACAAAATCC
ATTAGAACGGGGTGCTTAAT

Downstream 100 bases:

>100_bases
AGTATATAACAGTAAAGATGATGAAACAGCTTAGAAAAATAATTTAGTAAACTGTTAATTTGAACTTCTTTTATATTAAA
TTCAAAATAGAACTATATAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVA
RSLGKKDYDNLKSVILNAINITVVIMVVLTFIISIFKKDMITGLLGASQSIYPYAKEYISIVVLGGLFQALTLVICYIMT
SLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVI
KTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQM
IIFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGRSVEVGGL

Sequences:

>Translated_473_residues
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVA
RSLGKKDYDNLKSVILNAINITVVIMVVLTFIISIFKKDMITGLLGASQSIYPYAKEYISIVVLGGLFQALTLVICYIMT
SLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVI
KTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQM
IIFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGRSVEVGGL
>Mature_472_residues
GIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVAR
SLGKKDYDNLKSVILNAINITVVIMVVLTFIISIFKKDMITGLLGASQSIYPYAKEYISIVVLGGLFQALTLVICYIMTS
LGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKPI
LAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVIK
TIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMI
IFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGRSVEVGGL

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51781; Mature: 51650

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINITVVIMVVLTFIISIFKKDM
HHHHHHCCHHEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGLLGASQSIYPYAKEYISIVVLGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHH
PIAAFNYGAKNLVRVKEVVIKTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMIIFIPLLFILVGKFDIMGAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGRSVEVGGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure 
GIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINITVVIMVVLTFIISIFKKDM
HHHHHHCCHHEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGLLGASQSIYPYAKEYISIVVLGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHH
PIAAFNYGAKNLVRVKEVVIKTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMIIFIPLLFILVGKFDIMGAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGRSVEVGGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA