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The map label for this gene is 148380678

Identifier: 148380678

GI number: 148380678

Start: 2870583

End: 2871647

Strand: Reverse

Name: 148380678

Synonym: CBO2720

Alternate gene names: NA

Gene position: 2871647-2870583 (Counterclockwise)

Preceding gene: 148380679

Following gene: 148380677

Centisome position: 73.88

GC content: 31.92

Gene sequence:

>1065_bases
TTGGAGGGGATTATGAACAATTTTATTAAAATAGGAAATAAAAAAATAGGTGAAGGTGAAAAAACTTTTATTATAGCAGA
AATGTCAGCAAACCATCTTCAAAGTTTTGAAAGAGCAGTAGAAATAATAAAAAAAGCTAAAGAATCTGGAGCAGATGCTA
TAAAGCTTCAAACGTATACTCCAGATACTATAACTATAGATTGTAACAACGAATATTTTCAAATAAAACAAGGAACTATT
TGGGATGGAACAACTTTATATAAGCTTTATAAAAAAGCATATACCCCTTGGGAATGGCAGCCAAAGCTAAAAAAAATAGC
AGAGGATTTAGGATTAATTTGTTTTTCATCACCCTTTGACAAGACTTCAGTAGACTTTTTAGAGGATATGAATGTAGAAG
CTTACAAAATAGCTTCCTTTGAAATAACAGACATTCCTTTTATAGAATATATAGCATCAAAAGGAAAGCCTATAATAATG
TCTACAGGTATAGCAACTTTAGGTGATATAGAAGAGGCTATAAAAGCATGTCATAGAATGGGTAATTATGAAATAGTCCT
TTTAAAATGCACTTCAGCTTATCCAGCACCACTAGAAGATATAAATTTAAAAACCATACCAAATATGAAAGAAACATTTA
AAACAGTAGTGGGGCTTTCAGATCATACTTTAGGTCATTCAGTGGCCTTAGGGGCAGTAGCCTTAGGATCTAAAATAGTA
GAGAAACACTTTACTCTAAAAAGAGAAGATGGAGGCCCAGATGCGAAATTTTCTATGGAACCTGAAGAATTTAAAGCCAT
GATACAGGGCATAAGAGAAGTAGAAAAGGCGTTAGGTGGTGTTACCTATGATCTTACAGAAAAACAAAGAAATAGTAGGG
AACATTCTAGATCTTTGTTTGTGGTAAAAGATATTAAAAAAGGAGAAGTGTTCACGGAAGAAAATGTGAAGAGTATAAGA
CCAGGGTTTGGTATGGAAACTAAATATATTAAGTGTGTTTTAGGGAAAAAAGCAAAAAAAGATATAAAAAAGGGAACTCC
AATAAGTTTGGAAATAGTATATTAA

Upstream 100 bases:

>100_bases
AAATATTATTTAATTTTTTTATATTAGTGTTTATAATTAAGAAAAAAATGTTTTAAACGATAAATATAATAACGAATTTT
AGATGATTATGTAGATTACT

Downstream 100 bases:

>100_bases
GCAATAAGAAAAGTGTATTTACTCTGATGTAAAATAATGTACTAAGTATTAAATATGAGATTATATATTATAAGTAGTGG
TGGATTTAGTATGGATATGC

Product: N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MEGIMNNFIKIGNKKIGEGEKTFIIAEMSANHLQSFERAVEIIKKAKESGADAIKLQTYTPDTITIDCNNEYFQIKQGTI
WDGTTLYKLYKKAYTPWEWQPKLKKIAEDLGLICFSSPFDKTSVDFLEDMNVEAYKIASFEITDIPFIEYIASKGKPIIM
STGIATLGDIEEAIKACHRMGNYEIVLLKCTSAYPAPLEDINLKTIPNMKETFKTVVGLSDHTLGHSVALGAVALGSKIV
EKHFTLKREDGGPDAKFSMEPEEFKAMIQGIREVEKALGGVTYDLTEKQRNSREHSRSLFVVKDIKKGEVFTEENVKSIR
PGFGMETKYIKCVLGKKAKKDIKKGTPISLEIVY

Sequences:

>Translated_354_residues
MEGIMNNFIKIGNKKIGEGEKTFIIAEMSANHLQSFERAVEIIKKAKESGADAIKLQTYTPDTITIDCNNEYFQIKQGTI
WDGTTLYKLYKKAYTPWEWQPKLKKIAEDLGLICFSSPFDKTSVDFLEDMNVEAYKIASFEITDIPFIEYIASKGKPIIM
STGIATLGDIEEAIKACHRMGNYEIVLLKCTSAYPAPLEDINLKTIPNMKETFKTVVGLSDHTLGHSVALGAVALGSKIV
EKHFTLKREDGGPDAKFSMEPEEFKAMIQGIREVEKALGGVTYDLTEKQRNSREHSRSLFVVKDIKKGEVFTEENVKSIR
PGFGMETKYIKCVLGKKAKKDIKKGTPISLEIVY
>Mature_354_residues
MEGIMNNFIKIGNKKIGEGEKTFIIAEMSANHLQSFERAVEIIKKAKESGADAIKLQTYTPDTITIDCNNEYFQIKQGTI
WDGTTLYKLYKKAYTPWEWQPKLKKIAEDLGLICFSSPFDKTSVDFLEDMNVEAYKIASFEITDIPFIEYIASKGKPIIM
STGIATLGDIEEAIKACHRMGNYEIVLLKCTSAYPAPLEDINLKTIPNMKETFKTVVGLSDHTLGHSVALGAVALGSKIV
EKHFTLKREDGGPDAKFSMEPEEFKAMIQGIREVEKALGGVTYDLTEKQRNSREHSRSLFVVKDIKKGEVFTEENVKSIR
PGFGMETKYIKCVLGKKAKKDIKKGTPISLEIVY

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=301, Percent_Identity=29.5681063122924, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI21357081, Length=257, Percent_Identity=30.7392996108949, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 39721; Mature: 39721

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIMNNFIKIGNKKIGEGEKTFIIAEMSANHLQSFERAVEIIKKAKESGADAIKLQTYT
CCHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
PDTITIDCNNEYFQIKQGTIWDGTTLYKLYKKAYTPWEWQPKLKKIAEDLGLICFSSPFD
CCEEEEECCCCEEEEECCCEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEECCCCC
KTSVDFLEDMNVEAYKIASFEITDIPFIEYIASKGKPIIMSTGIATLGDIEEAIKACHRM
CCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHC
GNYEIVLLKCTSAYPAPLEDINLKTIPNMKETFKTVVGLSDHTLGHSVALGAVALGSKIV
CCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EKHFTLKREDGGPDAKFSMEPEEFKAMIQGIREVEKALGGVTYDLTEKQRNSREHSRSLF
HHHCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHCCHHHHCEEE
VVKDIKKGEVFTEENVKSIRPGFGMETKYIKCVLGKKAKKDIKKGTPISLEIVY
EEEECCCCCCCCCCCHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MEGIMNNFIKIGNKKIGEGEKTFIIAEMSANHLQSFERAVEIIKKAKESGADAIKLQTYT
CCHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
PDTITIDCNNEYFQIKQGTIWDGTTLYKLYKKAYTPWEWQPKLKKIAEDLGLICFSSPFD
CCEEEEECCCCEEEEECCCEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEECCCCC
KTSVDFLEDMNVEAYKIASFEITDIPFIEYIASKGKPIIMSTGIATLGDIEEAIKACHRM
CCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHC
GNYEIVLLKCTSAYPAPLEDINLKTIPNMKETFKTVVGLSDHTLGHSVALGAVALGSKIV
CCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EKHFTLKREDGGPDAKFSMEPEEFKAMIQGIREVEKALGGVTYDLTEKQRNSREHSRSLF
HHHCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHCCHHHHCEEE
VVKDIKKGEVFTEENVKSIRPGFGMETKYIKCVLGKKAKKDIKKGTPISLEIVY
EEEECCCCCCCCCCCHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]