Click here to switch to the map view.

The map label for this gene is vanR [H]

Identifier: 148379575

GI number: 148379575

Start: 1747617

End: 1748309

Strand: Reverse

Name: vanR [H]

Synonym: CBO1613

Alternate gene names: 148379575

Gene position: 1748309-1747617 (Counterclockwise)

Preceding gene: 148379577

Following gene: 148379574

Centisome position: 44.98

GC content: 29.87

Gene sequence:

>693_bases
ATGATTGAATATAAGGTTTTAATAGTTGATGATGAAGATGAAATAAGAGAAGCTATAGAAATTTATTTAAAAAATGAAGG
TATAACTGTTTTTAAAGCTAAAGATGGAATAGATGCCTTAATGCTTTTAGAAGACCATGATATCCATCTTATTATTATGG
ATATCATGATGCCTAAAATGGATGGCATTAACGCTACTTTTAAAATTAGAGAAAATAAAAACATTCCTATAATAATGCTT
TCTGCTAAATCTGAGGACACAGATAAGATACTAGGGCTTAATATAGGGGCAGATGATTATGTTACAAAACCCTTTAATAT
GCTAGAGCTAGTAGCTAGGGTTAAATCTCAGCTTAGAAGATATGTCAACTTAGGAAATTATAAAGAAACTGAGGATAAAG
TTGTGGCAGGAGCTCTTATATTAGATAAAAAAACAAAATTAATAATTGTAGATGGAAAAGAAATAAGACTTACCCCTATT
GAATATAGAATACTAGAACTTCTAATGGAAAACAAAGGTAGAGTTTTTTCCATTGAAGAAATATATGAAAAAGCTTGGAA
GGAGCCCTATTACAATGGTGAAAACACCGTAGCTGTGCATATAAGAAGAATAAGAGAAAAAATTGAAATTAACTCTAGAG
AACCAAGATATTTAAAGGTGGTGTGGGGAATTGGTTATAAAATCCAAGAATAA

Upstream 100 bases:

>100_bases
TTATTATTGTAGAAAAAAATAGTAAGGTTAATTTTGATGACCTATTTAGGAGGTGATAAAAATGTTATAATTTATTCCGT
AAAGAAAGGATGGGACAAGT

Downstream 100 bases:

>100_bases
ATTTATTTATATAATATGTTTCATTGTAGGTATATATATGCTGTCTCTTTCATTTTTAACCGGCTATGATTTAATAAAAA
ACAAAAGGTATCTTGTGAAA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKMDGINATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPI
EYRILELLMENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE

Sequences:

>Translated_230_residues
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKMDGINATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPI
EYRILELLMENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE
>Mature_230_residues
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKMDGINATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPI
EYRILELLMENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=35.8407079646018, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=36.1233480176211, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.4821428571429, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.4561403508772, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=33.1858407079646, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=32.5892857142857, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=32.4444444444444, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.061135371179, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=30.1310043668122, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787229, Length=214, Percent_Identity=32.2429906542056, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=28, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=29.4642857142857, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787487, Length=105, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=112, Percent_Identity=34.8214285714286, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26818; Mature: 26818

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKM
CCEEEEEEECCHHHHHHHHEEEEECCCEEEEEECCCCEEEEEEECCCEEEEEEEECCCCC
DGINATFKIRENKNIPIIMLSAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRR
CCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
YVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPIEYRILELLMENKGRVFSIEE
HHCCCCCCCCCCCEEEEEEEEECCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCEEEHHH
IYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE
HHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEEEECCEEECC
>Mature Secondary Structure
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKM
CCEEEEEEECCHHHHHHHHEEEEECCCEEEEEECCCCEEEEEEECCCEEEEEEEECCCCC
DGINATFKIRENKNIPIIMLSAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRR
CCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
YVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPIEYRILELLMENKGRVFSIEE
HHCCCCCCCCCCCEEEEEEEEECCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCEEEHHH
IYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE
HHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]