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The map label for this gene is nprM [H]

Identifier: 148379415

GI number: 148379415

Start: 1570906

End: 1572684

Strand: Reverse

Name: nprM [H]

Synonym: CBO1443

Alternate gene names: 148379415

Gene position: 1572684-1570906 (Counterclockwise)

Preceding gene: 148379416

Following gene: 148379414

Centisome position: 40.46

GC content: 30.3

Gene sequence:

>1779_bases
ATGAAAAGCAAAAAATTATTAGCTACAGTGTTAAGTGCTGTAATCACTTTCTCCGCAGTTTCAGCAGTTTCAGCTGCACC
TGTAGGAAAAGAAAGTAAAAGTGAACCAAAAATCACAACAATATCCTGGGACAAAAGTGAACAAAACACTAAAAAGGATG
CTACAGACATAAAGCAAAAGAAATTTAACAACGCTCAAGAAGTAACTAATTTCTTTGAAAAAAACATCTCTAAATTTGGG
GTAAAAAAAGGTACTCTTAAGAGTACTAAAACTTTAAAAGATGATAAAGGTAAAACTCACTATCATACAATTTATGAAGT
AGAAGGTATACCTGTATACTATGGAAGAATTGTATTTACTACTGAAAAGGACTCAACTATGAACTCTATAAATGGTAGAG
TTGATACTGTTTTTGAAAATGGAAATTGGAAAAACAAAATCAAACTATCAAAAGAAGACGCCATAGCAAAAGCTAAAGGT
GATATTAAAGATCAAAAATCAAATAGTGAAAAAGCTGATTTATATTTGTACAATTTTGAAGGAAAACCTTATGTAGTTTA
TTTGGTAAATACAATGACAGATAGCGGTAATTGGAATGTTTTTGTTAATGCTGAAGACGGCTCTATAGTAAATAAATTTG
ATACTACTCCTACTTTAGTTGAGAATAAAGATAAAAAATTACCTAATGCTAAAAAAATTAAAGATGAAGCTGAAAAAAAT
GAAGCTAAAAAGGCTAATGCTAGTAATGTAAATAGTGTAACTGATGTACAAGGCCAAAGCGTTAAAGGAATGGGAAGAAC
TAGCTTAGATGGACTAGTAAATCTTGATCTAACTTATGGCAGTGGAAGATATTATTTAAAAGACAATAATAGAAAAATTT
ATCTATATGATTTAAAAAATCAAGTTAGTGGTGACGATTTGTACAGATATATTATAGAACATTATTACTATGGTGCTCCT
GAATATAAACAGAGATTAATGTCTCAATCCGAACTAGTATCTAATTCAAATAATAATTTTATAAATGATAATCAAGTTAA
TTCTGTAGATGCTTATGTAAATACAGCTAAGACCTATGATTATTATAAAAATAAATTATCTAGAAATAGTATTGATAATA
AAGGTATGAATGTTAATGGATTTGTCCATGTAGACAAAAATTTGGGTAACGCCTTTTGGTATGGACCATATGATAGTATG
TTCTTTGGTGATGGTGACGGAGTACGCTTCTCTGCTCTTGCTAAATCTTTAGATGTTGTAGGACATGAACTTAGTCATGG
TGTTACTAATAAACAATCTAACCTTAATTATGCAAATGAATCTGGTGCTTTAAACGAATCCTTCTCAGATATTATGGGAA
CAGCTGTTGAGGGTAAAAACTTTGTATTAGGTGAAGATTGCTGGATTGCTGGAGGGGTAATGAGAGATATGGAAAACCCA
TCTAGAGGAAATCAACCAGCTCATATGAAAGATTATGTATATATGTCTGAAGATAATGGTGGGGTTCATAAAAATTCAGG
TATAATAAACCATGCGGCTTATTTAATTGCAGATGGATTTGAAAAAATGGGTGCAAAAGATAGTAAAGATATTATGGGAA
AACTATTTTATATAGCTAATTGCTATTACTGGGATCAAACAACAGATTTTGCTAAATGTAGAAATGATGTAGTTAGAGTT
GCTAAAGATCTTTACGGTGAAAATAGTAAAGAAGTTCAAATTGTAAAAAATGCTTTTGATAAAGTTGGAGTATCTGCTAC
ACCTCAATTATCATTATAA

Upstream 100 bases:

>100_bases
TTATAAAATATATTTATAAAACTATATAATTTTAGCATTTTACTTTATAAACATTAATAGGTTTATAAGTAAAAATATAT
TAAATGGGGGTTATTTATTC

Downstream 100 bases:

>100_bases
TCCAAATATCATTAAAACTGTAAAACTATAGATATAACTATATAAAAAATTAGATTTAAATAAATAAGATGATTTCTATT
CAAGTAAGAAATCATCTTAT

Product: secreted protease

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSEPKITTISWDKSEQNTKKDATDIKQKKFNNAQEVTNFFEKNISKFG
VKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMNSINGRVDTVFENGNWKNKIKLSKEDAIAKAKG
DIKDQKSNSEKADLYLYNFEGKPYVVYLVNTMTDSGNWNVFVNAEDGSIVNKFDTTPTLVENKDKKLPNAKKIKDEAEKN
EAKKANASNVNSVTDVQGQSVKGMGRTSLDGLVNLDLTYGSGRYYLKDNNRKIYLYDLKNQVSGDDLYRYIIEHYYYGAP
EYKQRLMSQSELVSNSNNNFINDNQVNSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFVHVDKNLGNAFWYGPYDSM
FFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGALNESFSDIMGTAVEGKNFVLGEDCWIAGGVMRDMENP
SRGNQPAHMKDYVYMSEDNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMGKLFYIANCYYWDQTTDFAKCRNDVVRV
AKDLYGENSKEVQIVKNAFDKVGVSATPQLSL

Sequences:

>Translated_592_residues
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSEPKITTISWDKSEQNTKKDATDIKQKKFNNAQEVTNFFEKNISKFG
VKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMNSINGRVDTVFENGNWKNKIKLSKEDAIAKAKG
DIKDQKSNSEKADLYLYNFEGKPYVVYLVNTMTDSGNWNVFVNAEDGSIVNKFDTTPTLVENKDKKLPNAKKIKDEAEKN
EAKKANASNVNSVTDVQGQSVKGMGRTSLDGLVNLDLTYGSGRYYLKDNNRKIYLYDLKNQVSGDDLYRYIIEHYYYGAP
EYKQRLMSQSELVSNSNNNFINDNQVNSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFVHVDKNLGNAFWYGPYDSM
FFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGALNESFSDIMGTAVEGKNFVLGEDCWIAGGVMRDMENP
SRGNQPAHMKDYVYMSEDNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMGKLFYIANCYYWDQTTDFAKCRNDVVRV
AKDLYGENSKEVQIVKNAFDKVGVSATPQLSL
>Mature_592_residues
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSEPKITTISWDKSEQNTKKDATDIKQKKFNNAQEVTNFFEKNISKFG
VKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMNSINGRVDTVFENGNWKNKIKLSKEDAIAKAKG
DIKDQKSNSEKADLYLYNFEGKPYVVYLVNTMTDSGNWNVFVNAEDGSIVNKFDTTPTLVENKDKKLPNAKKIKDEAEKN
EAKKANASNVNSVTDVQGQSVKGMGRTSLDGLVNLDLTYGSGRYYLKDNNRKIYLYDLKNQVSGDDLYRYIIEHYYYGAP
EYKQRLMSQSELVSNSNNNFINDNQVNSVDAYVNTAKTYDYYKNKLSRNSIDNKGMNVNGFVHVDKNLGNAFWYGPYDSM
FFGDGDGVRFSALAKSLDVVGHELSHGVTNKQSNLNYANESGALNESFSDIMGTAVEGKNFVLGEDCWIAGGVMRDMENP
SRGNQPAHMKDYVYMSEDNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMGKLFYIANCYYWDQTTDFAKCRNDVVRV
AKDLYGENSKEVQIVKNAFDKVGVSATPQLSL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 66188; Mature: 66188

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSEPKITTISWDKSEQNTKKDATDIKQK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
KFNNAQEVTNFFEKNISKFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEEEE
TEKDSTMNSINGRVDTVFENGNWKNKIKLSKEDAIAKAKGDIKDQKSNSEKADLYLYNFE
ECCCCHHHHCCCEEEEEEECCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCEEEEEEEC
GKPYVVYLVNTMTDSGNWNVFVNAEDGSIVNKFDTTPTLVENKDKKLPNAKKIKDEAEKN
CCEEEEEEEEEECCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
EAKKANASNVNSVTDVQGQSVKGMGRTSLDGLVNLDLTYGSGRYYLKDNNRKIYLYDLKN
HHHHCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCC
QVSGDDLYRYIIEHYYYGAPEYKQRLMSQSELVSNSNNNFINDNQVNSVDAYVNTAKTYD
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
YYKNKLSRNSIDNKGMNVNGFVHVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVV
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCEEECCCCEEHHHHHHHHHHH
GHELSHGVTNKQSNLNYANESGALNESFSDIMGTAVEGKNFVLGEDCWIAGGVMRDMENP
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCEEECCHHHHCCCC
SRGNQPAHMKDYVYMSEDNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMGKLFYIAN
CCCCCCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHCHHHHCCCCCHHHHHHEEEEEE
CYYWDQTTDFAKCRNDVVRVAKDLYGENSKEVQIVKNAFDKVGVSATPQLSL
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSEPKITTISWDKSEQNTKKDATDIKQK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
KFNNAQEVTNFFEKNISKFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEEEE
TEKDSTMNSINGRVDTVFENGNWKNKIKLSKEDAIAKAKGDIKDQKSNSEKADLYLYNFE
ECCCCHHHHCCCEEEEEEECCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCEEEEEEEC
GKPYVVYLVNTMTDSGNWNVFVNAEDGSIVNKFDTTPTLVENKDKKLPNAKKIKDEAEKN
CCEEEEEEEEEECCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
EAKKANASNVNSVTDVQGQSVKGMGRTSLDGLVNLDLTYGSGRYYLKDNNRKIYLYDLKN
HHHHCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCC
QVSGDDLYRYIIEHYYYGAPEYKQRLMSQSELVSNSNNNFINDNQVNSVDAYVNTAKTYD
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
YYKNKLSRNSIDNKGMNVNGFVHVDKNLGNAFWYGPYDSMFFGDGDGVRFSALAKSLDVV
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCEEECCCCEEHHHHHHHHHHH
GHELSHGVTNKQSNLNYANESGALNESFSDIMGTAVEGKNFVLGEDCWIAGGVMRDMENP
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCEEECCHHHHCCCC
SRGNQPAHMKDYVYMSEDNGGVHKNSGIINHAAYLIADGFEKMGAKDSKDIMGKLFYIAN
CCCCCCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHCHHHHCCCCCHHHHHHEEEEEE
CYYWDQTTDFAKCRNDVVRVAKDLYGENSKEVQIVKNAFDKVGVSATPQLSL
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]