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The map label for this gene is rnz [H]

Identifier: 148379351

GI number: 148379351

Start: 1499317

End: 1500357

Strand: Direct

Name: rnz [H]

Synonym: CBO1376

Alternate gene names: 148379351

Gene position: 1499317-1500357 (Clockwise)

Preceding gene: 148379350

Following gene: 148379352

Centisome position: 38.57

GC content: 31.22

Gene sequence:

>1041_bases
ATGGTTGATTTGGCTTTATTAGGATGTGGGGGAGGCATGCCTATTCCAGATAGGTTCTTATCTTCCCTTCTTATGAATTA
TAGAGGGAGAAAAATACTTATAGATTGTGGAGAAGGAACTCAAGTATCTATGAAAATACTAGGGTGGGGCTTTAAGTCTA
TTGATATTATATGTATAACTCATATGCATGGAGATCATGTAGTTGGGCTACCAGGGCTCTTGGCTACTATAGGTAATAGT
GGCAGAGAAGAGCCTTTAACTATAATAGGTCCAGAAGGCATAGAAAATGTAATAACTGGACTTAGAACTATAGTTCCCTA
TTTACCTTATGATATAGTTATAATAGAAAATCCTAAAGAATCATTAAATGTAAATGTGCTGAAAAATGGTATGGAAGTAT
TAAAAGAATATGGTAGCGGCAATTTAATAAAGAATAATAGCTTAAAAGATTGTATAAAAAATGGAGAAGATAGTATTAAT
CAATATGAAAACTATAATGATAAGCTAAGATATGATATAGAAATTTCTACATTGGAATTAGACCATTCTTGTCCTTGCAT
AGGATATGGATTTTATATTAATAGAAAGCCTAAATTTAATCTAGAAAAAGCTGAAGGAAATAATGTACCGAAGTTTTTAT
GGAGTAGACTTCAAAAAGGAGAAAGTTTAGTTTATGAGGGGATAAAATATAATTCCAGTATGGTTATGGGGAGAGGCCGT
AAAGGAATAAAATTAAATTATGTTACAGATACAAGACCAATAGATCCTATAATAGATTTTATAAAAAATAGCGATTTGTT
CATATGTGAAGGAACTTATGGACAGGATGAAGATTTACATAAAGCCATAAAAAATAAACATATGACTTTTAGAGAAGGAG
CTAAGTTGGCTAACAAAGGTAAGGTGTCACAGCTTATATTAACGCATTTTAGTCCGGCTATGATAGATCCAGAAAGTTTT
AAACAAAATGCTATGGAAGTTTTTCCAGATACTTTAATAGGAAAAGACAGACTTATTAAAACATTGTCTTTTAAGGAATA
G

Upstream 100 bases:

>100_bases
AAATAATGACATATAATAATAATTAAGATATAAGTGAGTAACAATAAATGCAAATTATTAATATGAAAATAATATAAAAA
CTAAAGTTAGGAGGAATAAA

Downstream 100 bases:

>100_bases
TTATATATTTTTTAAGATTGAAACATAATTTATTACATGATAAAATATTTTTATTATAAAATATAATTTAAAATTTAATT
AAAGATGAATGAAGATTATT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNS
GREEPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKEYGSGNLIKNNSLKDCIKNGEDSIN
QYENYNDKLRYDIEISTLELDHSCPCIGYGFYINRKPKFNLEKAEGNNVPKFLWSRLQKGESLVYEGIKYNSSMVMGRGR
KGIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGQDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESF
KQNAMEVFPDTLIGKDRLIKTLSFKE

Sequences:

>Translated_346_residues
MVDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNS
GREEPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKEYGSGNLIKNNSLKDCIKNGEDSIN
QYENYNDKLRYDIEISTLELDHSCPCIGYGFYINRKPKFNLEKAEGNNVPKFLWSRLQKGESLVYEGIKYNSSMVMGRGR
KGIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGQDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESF
KQNAMEVFPDTLIGKDRLIKTLSFKE
>Mature_346_residues
MVDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNS
GREEPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKEYGSGNLIKNNSLKDCIKNGEDSIN
QYENYNDKLRYDIEISTLELDHSCPCIGYGFYINRKPKFNLEKAEGNNVPKFLWSRLQKGESLVYEGIKYNSSMVMGRGR
KGIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGQDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESF
KQNAMEVFPDTLIGKDRLIKTLSFKE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=323, Percent_Identity=29.1021671826625, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI87082078, Length=345, Percent_Identity=28.4057971014493, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 38769; Mature: 38769

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICIT
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCEEEEEEE
HMHGDHVVGLPGLLATIGNSGREEPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKE
EECCCEEECCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCCH
SLNVNVLKNGMEVLKEYGSGNLIKNNSLKDCIKNGEDSINQYENYNDKLRYDIEISTLEL
HCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCHHHHHHHCCCCCCEEEEEEEEEEEE
DHSCPCIGYGFYINRKPKFNLEKAEGNNVPKFLWSRLQKGESLVYEGIKYNSSMVMGRGR
CCCCCEEEEEEEECCCCCCCEECCCCCCCHHHHHHHHHCCCCEEHHCEEECCEEEEECCC
KGIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGQDEDLHKAIKNKHMTFREGAKLANKG
CCEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHCCHHHCCC
KVSQLILTHFSPAMIDPESFKQNAMEVFPDTLIGKDRLIKTLSFKE
CHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHCCCCC
>Mature Secondary Structure
MVDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICIT
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCEEEEEEE
HMHGDHVVGLPGLLATIGNSGREEPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKE
EECCCEEECCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCCH
SLNVNVLKNGMEVLKEYGSGNLIKNNSLKDCIKNGEDSINQYENYNDKLRYDIEISTLEL
HCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCHHHHHHHCCCCCCEEEEEEEEEEEE
DHSCPCIGYGFYINRKPKFNLEKAEGNNVPKFLWSRLQKGESLVYEGIKYNSSMVMGRGR
CCCCCEEEEEEEECCCCCCCEECCCCCCCHHHHHHHHHCCCCEEHHCEEECCEEEEECCC
KGIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGQDEDLHKAIKNKHMTFREGAKLANKG
CCEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHCCHHHCCC
KVSQLILTHFSPAMIDPESFKQNAMEVFPDTLIGKDRLIKTLSFKE
CHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA