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The map label for this gene is xdhA2 [H]

Identifier: 148379266

GI number: 148379266

Start: 1396200

End: 1398497

Strand: Direct

Name: xdhA2 [H]

Synonym: CBO1285

Alternate gene names: 148379266

Gene position: 1396200-1398497 (Clockwise)

Preceding gene: 148379265

Following gene: 148379267

Centisome position: 35.92

GC content: 32.42

Gene sequence:

>2298_bases
ATGGAAGATTCTTATGATTTAATTGGAAAAAGCATAAATAGAGTAGATGCAGTAGCTAAAGTTACAGGTAGAGCTAAGTA
TTGCTCAGATCATTTTGAAGCTAATTCACTTGTAGGAATGGTTTTAAGAAGTCCCTATGCTCATGCAAAAGTAAAAAATA
TAGATACTAAAGAAGCTGAAAGCTTAGATGGTGTTGAAGCTGTATTAACGTATAAAAATGTACCAAATACGAAATTTCCT
ACGGCAGGACATCCATATTCATTAGATCCAAGTCATAGAGACATAGAAGATTATGTATTACTTACAGACAAAGCACGCTT
TGTAGGAGATGCAGTTGCAGCAGTTATTGCGACTGATGAACTTATAGCCAAAAAAGCCTTAAAATTAATAAAAGTAGAAT
ATGAAGTTTTGCCTTTTGTAATCGATCAAGAAGAAGCAATAAAAGAGGGAGCTCCTGTTATTCATGATGAAAGGCCCAAT
AATATAGTTAGTGATTTTGGTATAACAGTAGGAGATCCAGATGAAGTATTTAAAAATGCAGATAAAATTTATAAAGGTCA
ATATGAAACTCAAATAGTGCAACATTGTCAAATGGAAACGCACAATGCTATGGCAAAGCTTGATGAGAAAGGTAGAATGC
TTATTATAACATCAACACAAATACCACATATTGTACGAAGAATAGTTTCAAAAGCTTGTAATTTACCTATTGGTAAAATA
AGAGTAATAAAGCCTTATGTTGGTGGAGGCTTTGGAGGAAAGCAAGATGTTATAATAGAACCACTTACAGCTATAATGTC
TCTTGCAGTTAATGGAAGATGTGTAAGGTTACAATTAAGTAGAGAAGAGGCAATTGTTGCAACTAGAACAAGACATGCAA
TGAGAGTAAATATCAAAATAGCTTTATCAAAAGATAATAAAATAGAAGGTTATGATATAGAGAACTTTGTAAATAATGGA
GCTTATGCATCCCATGGACATTCAATTGCTATGAGTGCAGGAAGTAAAATTAGACCTCTTTATGATATAAAGGCAGAAAA
ATATCGTCCCAAAACTATATATACTAATCTTCCAGTTGCAGGTGCAATGAGAGCATATGGTATACCACAAATGTGTTTTG
TTATAGAATCTATGATTGATGATATATGTAATGATCTAAATATAGACCCTGTAGATTTTAGACTTAATAGTTTTATAAAG
AAAGGTCATATAGATAAGGAATCAGATCTTGTAGTTAGAACCTTTGGATTACCAGAATGTTTAAAAAGAGGTAGAAAATT
AATAGATTGGGAGGGAAAAAGAGAATTATATAAAAATCAAAATGGTCCTATAAGAAAAGGTGTTGGAATGGCCTGTTTTA
GTTATTTTTCAGGAACTTGGCCAGTATCACTTGAGGCAGCGGGAACAAGAATAGTAATGAATCAAGATGGTTCAGTCCAA
GTTCAAGTAGGAGCTACAGAAATAGGACAGGGTAGTGATACAGTATTTAGTCAAATGGCAGCAGAAACTATTGGAATACC
ATTTGATATGGTAACAATAGTCTCCCAGCAAGATACAGATATTACTCCTTTTGATACAGGATCCTATGCATCAAGACAAT
CTTTTATAGCAGGCCAAGCTATAAAAAAAGCAGCAACAGAAGTAAAAAGAAAAGCTCTAAAAATTGCCAGTGATAAATGT
GGATTAGATGCAGAGCTTTTGGATATTGTAGATGCAAAGGTGATAGAAAAAGGATTAAGAAGAGAACTTTATACTTTAGA
AGAAATTGCGATGGAGGCATATTACAATAGAGAAAAATATGCACCTATAACAAGTGATTTAACCGTAAAGGTTAAAAATA
ATGCTATAGCCTATGGGGCAACCTTTGTAGAAGTAGAAGTTGATATAAGAACAGGAAAAATAAAAGTTTTAGATATTTAT
AACATACATGATTCAGGAAAAATTTTAAATAAAAAGTTAGCAGAAGGACAAGTACACGGTGGTGTTAGTATGGCTTTAGG
ATTTGCCTTATCAGAAAAATTCATAATAGATGAGAAAACAGGATCTATAATAAACAATAATCTTTTACATTATAAACTTC
CAACTATTATGGATACTCCAAACATAAAATGTGAATTTGTAAATACCTATGATCCAACATCTAGTTATGGACAAAAATCT
TTAGGTGAAAATACAACAATCTCTCCAGCTCCAGCTATACGTAATGCCGTATTAAATGCAACAGGAGTAGCATTTAATAA
ATTGCCAATGGATGCTCAATCTGTTTTTGAGAAATTTAAAGAGGTTGGACTTATATAG

Upstream 100 bases:

>100_bases
CTAGTAAATATAAGAGAGAAGTAAAAGAAAAAAAAGAATCATAAAATAAATAATATATATAGTTATTATATAATGCAAAA
TATTAAAGGGGGAACTATAC

Downstream 100 bases:

>100_bases
GAGGCGAAATAATATGTATGATATAAATGAAATTTTAGAACCTAAAACATTAGAAAAGGCATTAGAATTATTATCAGAAC
ACGATAATTTAACGGTAATA

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIVATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKESDLVVRTFGLPECLKRGRKLIDWEGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKALKIASDKC
GLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI

Sequences:

>Translated_765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIVATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKESDLVVRTFGLPECLKRGRKLIDWEGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKALKIASDKC
GLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
>Mature_765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIVATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKESDLVVRTFGLPECLKRGRKLIDWEGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKALKIASDKC
GLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=715, Percent_Identity=26.7132867132867, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI71773480, Length=737, Percent_Identity=26.3229308005427, Blast_Score=180, Evalue=6e-45,
Organism=Escherichia coli, GI1789230, Length=753, Percent_Identity=46.6135458167331, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=809, Percent_Identity=30.655129789864, Blast_Score=349, Evalue=4e-97,
Organism=Escherichia coli, GI1786478, Length=775, Percent_Identity=26.9677419354839, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17540638, Length=749, Percent_Identity=25.5006675567423, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17539860, Length=736, Percent_Identity=24.320652173913, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566215, Length=732, Percent_Identity=24.0437158469945, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17737937, Length=744, Percent_Identity=27.4193548387097, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24647193, Length=729, Percent_Identity=24.2798353909465, Blast_Score=149, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24647199, Length=725, Percent_Identity=23.0344827586207, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24647195, Length=729, Percent_Identity=22.7709190672154, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24647201, Length=739, Percent_Identity=23.0040595399188, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24647197, Length=717, Percent_Identity=23.1520223152022, Blast_Score=119, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84427; Mature: 84427

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAE
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCCHHHH
SLDGVEAVLTYKNVPNTKFPTAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDE
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
LIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPNNIVSDFGITVGDPDEVFKNA
HHHHHHHHHHHEEHHHCCEEECCHHHHHCCCCCEECCCCCCHHHHCCCCCCCHHHHHHCH
DKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCE
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIVATRTRHAMRVNIKI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEEEEEE
ALSKDNKIEGYDIENFVNNGAYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVA
EECCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCH
GAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIKKGHIDKESDLVVRTFGLPEC
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHH
LKRGRKLIDWEGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
HHCCCEEECCCCCHHHHCCCCCCCHHCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCEE
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQA
EEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IKKAATEVKRKALKIASDKCGLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIYNIHDSGKILNKKLAEGQVHG
CCCCCCEEEEEECCEEEEEEEEEEEEEEEEECEEEEEEEEEECCCCHHHHHHHHCCCCCC
GVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
CHHHHHHHHHCCEEEEECCCCCHHCCCEEEEECCCEECCCCCEEEEEECCCCCCHHHHHH
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAE
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCCHHHH
SLDGVEAVLTYKNVPNTKFPTAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDE
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
LIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPNNIVSDFGITVGDPDEVFKNA
HHHHHHHHHHHEEHHHCCEEECCHHHHHCCCCCEECCCCCCHHHHCCCCCCCHHHHHHCH
DKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCE
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIVATRTRHAMRVNIKI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEEEEEE
ALSKDNKIEGYDIENFVNNGAYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVA
EECCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCH
GAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIKKGHIDKESDLVVRTFGLPEC
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHH
LKRGRKLIDWEGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
HHCCCEEECCCCCHHHHCCCCCCCHHCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCEE
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQA
EEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IKKAATEVKRKALKIASDKCGLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIYNIHDSGKILNKKLAEGQVHG
CCCCCCEEEEEECCEEEEEEEEEEEEEEEEECEEEEEEEEEECCCCHHHHHHHHCCCCCC
GVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
CHHHHHHHHHCCEEEEECCCCCHHCCCEEEEECCCEECCCCCEEEEEECCCCCCHHHHHH
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]