Click here to switch to the map view.

The map label for this gene is dut [H]

Identifier: 148379218

GI number: 148379218

Start: 1354911

End: 1355537

Strand: Direct

Name: dut [H]

Synonym: CBO1235

Alternate gene names: 148379218

Gene position: 1354911-1355537 (Clockwise)

Preceding gene: 148379216

Following gene: 148379220

Centisome position: 34.86

GC content: 27.75

Gene sequence:

>627_bases
ATGAACAATAAAGTTAATGTTTATATAAAGGTTTCAGAGGATGGTAAAATGCCAAGCTATGGATCTTTAAATGCTGCAGG
CTGTGATTTATATGCTACAAAGTATATGGAGATAAAGCCAGGAGAAACAAAAGTTATGCCATTAAATTTTGTTATGGCTA
TGGATGAAAACTTAGAAGCACAAATAAGACCAAGAAGTGGATTATCCTTAAAAACTAACTTAAGAGTTCCTAATAGTCCA
GGAACTATAGATAGTGATTATAGGGATACAGTAGGAGTTATACTGGAAAATACATATGATATAGCTAATTTGCCTTATGA
TATAGCAAAAGATCCTAATGTATTGAAAGTTTTAAAAGAAAAATATAAAGAAATATCTTTAATTGATTATTTAAATAGTA
AAGAAGATATAAATCTAGATAATAATAATTTTTTAAGTATATTGAAGCAAAAGATATATTTAGATGAAAAGGGAAATCCT
TATGGAACTATATATATAAATAAAGGAGAGAGAATAGCTCAAATGGTATTCAAAGAATATAAAAGAGCTAATTTTATAGA
ATGCGAAAATCCTCAAAAAATAGGAGAAAATAGAGGCGGAGGATTTGGACATACAGGAGTAAAATAA

Upstream 100 bases:

>100_bases
TATAAAAGATTACTCATTAATATTATAATCATATATTTTTATAGTATAATATGTATAGTTAACAAAAGTATAAGATTATG
TCAAAAGAGGTGAAAGTAGT

Downstream 100 bases:

>100_bases
TATTAATAAAAGGTGCTGAAAGTTAATTTTCAGCACCTTTTATTAATATTATTTTAGTTATTTAGTTTGTTACATTCACT
AAGAGTTTTTACATTAACAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGETKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLIDYLNSKEDINLDNNNFLSILKQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPQKIGENRGGGFGHTGVK

Sequences:

>Translated_208_residues
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGETKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLIDYLNSKEDINLDNNNFLSILKQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPQKIGENRGGGFGHTGVK
>Mature_208_residues
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGETKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLIDYLNSKEDINLDNNNFLSILKQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPQKIGENRGGGFGHTGVK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 23504; Mature: 23504

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGETKVMPLNFVMAMDENLEA
CCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEEEEEEECCCCEE
QIRPRSGLSLKTNLRVPNSPGTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKE
EECCCCCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KYKEISLIDYLNSKEDINLDNNNFLSILKQKIYLDEKGNPYGTIYINKGERIAQMVFKEY
HHHHEEHHHHCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHH
KRANFIECENPQKIGENRGGGFGHTGVK
HCCCCEECCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGETKVMPLNFVMAMDENLEA
CCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEEEEEEECCCCEE
QIRPRSGLSLKTNLRVPNSPGTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKE
EECCCCCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KYKEISLIDYLNSKEDINLDNNNFLSILKQKIYLDEKGNPYGTIYINKGERIAQMVFKEY
HHHHEEHHHHCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHH
KRANFIECENPQKIGENRGGGFGHTGVK
HCCCCEECCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA