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The map label for this gene is rppH

Identifier: 148361184

GI number: 148361184

Start: 3418143

End: 3418670

Strand: Reverse

Name: rppH

Synonym: LPC_3158

Alternate gene names: 148361184

Gene position: 3418670-3418143 (Counterclockwise)

Preceding gene: 148361186

Following gene: 148361183

Centisome position: 95.59

GC content: 43.56

Gene sequence:

>528_bases
ATGGTTATCGATCGTGCCGGATATCGCTTGAATGTAGGTATTATACTCGTCAACGATTCCGATAGAGTTTTTTGGGGGAG
ACGAAGCGGGCATGACGCTTGGCAATTCCCGCAAGGTGGATTGGCACCAGGCGAGACGGCCATGCAGGCAATGTATCGTG
AATTGCATGAAGAAGTGGGGTTAGATAAAGGTGATGTTGAAATATTGGGTTCGACCAGGCGTTGGCTAAAGTATCGACTT
CCGAAGCAATATTTGCGTCATGGCAGTGAGCCTTTGGTGATTGGCCAGAAACAAAAATGGTATTTGTTAAAGCTTGTAAC
AAGCGAGCAAAAAGTCAGATTGGATTTGAGTGATTCTCCCGAATTCGATAGCTGGCGGTGGGTGGATTTTCATGAGCCTG
AGCAACAAGTTATTTTCTTTAAGAGGCAGGTTTATATTCAAGCGTTAAAAGAATTAGAACCTTTGTTAAAAAAAGAACGC
CGTACCCCTTATGGCTTAAAACGTAAAAGAGGTAATCAAAGAGCTTAG

Upstream 100 bases:

>100_bases
GGAATAAATTAGTCCAAATAATATTTACAGATTTAATTGTAAGCTCTTGTACTTTGTGGAAAAATCAAGTTATTAACGGT
TTATTCTAAGCAGTGACATC

Downstream 100 bases:

>100_bases
ATGCTTAAAATACTTAAACGGATAGTACAAGATGTTACCGCTGCCAGTGATTTGAAAGAAGCACTTGGTATTTTGGTGCA
ACGTATTAATACAGCCATTA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MVIDRAGYRLNVGIILVNDSDRVFWGRRSGHDAWQFPQGGLAPGETAMQAMYRELHEEVGLDKGDVEILGSTRRWLKYRL
PKQYLRHGSEPLVIGQKQKWYLLKLVTSEQKVRLDLSDSPEFDSWRWVDFHEPEQQVIFFKRQVYIQALKELEPLLKKER
RTPYGLKRKRGNQRA

Sequences:

>Translated_175_residues
MVIDRAGYRLNVGIILVNDSDRVFWGRRSGHDAWQFPQGGLAPGETAMQAMYRELHEEVGLDKGDVEILGSTRRWLKYRL
PKQYLRHGSEPLVIGQKQKWYLLKLVTSEQKVRLDLSDSPEFDSWRWVDFHEPEQQVIFFKRQVYIQALKELEPLLKKER
RTPYGLKRKRGNQRA
>Mature_175_residues
MVIDRAGYRLNVGIILVNDSDRVFWGRRSGHDAWQFPQGGLAPGETAMQAMYRELHEEVGLDKGDVEILGSTRRWLKYRL
PKQYLRHGSEPLVIGQKQKWYLLKLVTSEQKVRLDLSDSPEFDSWRWVDFHEPEQQVIFFKRQVYIQALKELEPLLKKER
RTPYGLKRKRGNQRA

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=176, Percent_Identity=50.5681818181818, Blast_Score=185, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_LEGPA (Q5X115)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_125233.1
- ProteinModelPortal:   Q5X115
- SMR:   Q5X115
- STRING:   Q5X115
- GeneID:   3117001
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp2931
- LegioList:   lpp2931
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- BioCyc:   LPNE297246:LPP2931-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20709; Mature: 20709

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIDRAGYRLNVGIILVNDSDRVFWGRRSGHDAWQFPQGGLAPGETAMQAMYRELHEEVG
CEECCCCCEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
LDKGDVEILGSTRRWLKYRLPKQYLRHGSEPLVIGQKQKWYLLKLVTSEQKVRLDLSDSP
CCCCCEEEECCHHHHHHHHCCHHHHHCCCCCEEEECCCCEEEEEEECCCCEEEEECCCCC
EFDSWRWVDFHEPEQQVIFFKRQVYIQALKELEPLLKKERRTPYGLKRKRGNQRA
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MVIDRAGYRLNVGIILVNDSDRVFWGRRSGHDAWQFPQGGLAPGETAMQAMYRELHEEVG
CEECCCCCEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
LDKGDVEILGSTRRWLKYRLPKQYLRHGSEPLVIGQKQKWYLLKLVTSEQKVRLDLSDSP
CCCCCEEEECCHHHHHHHHCCHHHHHCCCCCEEEECCCCEEEEEEECCCCEEEEECCCCC
EFDSWRWVDFHEPEQQVIFFKRQVYIQALKELEPLLKKERRTPYGLKRKRGNQRA
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA