Definition Legionella pneumophila str. Corby chromosome, complete genome.
Accession NC_009494
Length 3,576,470

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The map label for this gene is phaB [H]

Identifier: 148361174

GI number: 148361174

Start: 3407896

End: 3408651

Strand: Reverse

Name: phaB [H]

Synonym: LPC_3148

Alternate gene names: 148361174

Gene position: 3408651-3407896 (Counterclockwise)

Preceding gene: 148361179

Following gene: 148361173

Centisome position: 95.31

GC content: 43.39

Gene sequence:

>756_bases
TTGAATCAGACAAACACGCAAGAAGCCAAGGTTGCTTTAGTGACCGGGGGCGCTAAACGTATCGGCGCAGCAATTGTTAA
AAAATTACATCTCTCTGGATATCAGGTAGCCATCCATTGTCATTCTGCTTTGCATGAGGCAGATATTCTGGCCAAACATT
TGAATCAGGTACGAATGAATAGCGCCATTGTCTTGCAAAAAGAATTAACTGAGCCTGGCGCAGCAGAGGAGATCATATCC
AAAGTGAAACATTGGGCAGGCCGTTTGGATTTGCTGGTCAATAATGCTTCTGTTTTTAAACGAACGGATTGCCATTTTTT
GAATGAGGCAGACTGGCAATATCTGTTTGCAGTGAATGTCCAGGTCCCCTTTCTACTGAGTATGGCAGCTTGTCCTTTAC
TAGCTCCATGCAAGGGTTCCATTATTAACATAACTGATATTCATGCAGATAAGCCACTTAAAGGATATTCGGTATATTGT
CAAACTAAAGCCGCATTGGAGATGCAAACGAGGTCGCTTGCTCGTGAGTTGGCGCCAGAAATAAGAGTCAATGCAGTAGC
ACCCGGCGCCATTGCCTGGCCCGAGAATGACAATAGTTTAACTGCGGAAGCACAACAAAAAATTATCGAGAAAACACCAT
TAAAAAGGCATGGCAGTCCTGATTTTATCGCGCAGGCTGTTCTCTCTTTAGCTGAAAATACATTCATCACTGGTCAAACA
TTGAAAGTAGATGGAGGTAGAAGTTTGACAAGCTAG

Upstream 100 bases:

>100_bases
TGAAGTGTACACAATAATACTTGAGGATTCGAGCATCCTGGCTGATTACTTTTTGCAGTGAGGTTGCGAAAGGAGTCTGT
TACCATATGGGGAACCTACC

Downstream 100 bases:

>100_bases
AGTTGTATACTGGATTTCATTTCAAATGCTCAATTTACTATATAGGGATTATTATTATGTCAAAATGGATTTTATTATCT
GGCTCCTTTTTTTTATGCCT

Product: pteridine reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORF6 [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCHSALHEADILAKHLNQVRMNSAIVLQKELTEPGAAEEIIS
KVKHWAGRLDLLVNNASVFKRTDCHFLNEADWQYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYC
QTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKRHGSPDFIAQAVLSLAENTFITGQT
LKVDGGRSLTS

Sequences:

>Translated_251_residues
MNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCHSALHEADILAKHLNQVRMNSAIVLQKELTEPGAAEEIIS
KVKHWAGRLDLLVNNASVFKRTDCHFLNEADWQYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYC
QTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKRHGSPDFIAQAVLSLAENTFITGQT
LKVDGGRSLTS
>Mature_251_residues
MNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCHSALHEADILAKHLNQVRMNSAIVLQKELTEPGAAEEIIS
KVKHWAGRLDLLVNNASVFKRTDCHFLNEADWQYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYC
QTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKRHGSPDFIAQAVLSLAENTFITGQT
LKVDGGRSLTS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=31.0077519379845, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=31.2252964426877, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=29.0076335877863, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=31.6872427983539, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=29.5081967213115, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=29.9180327868852, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=33.1521739130435, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=26.7441860465116, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI66933014, Length=172, Percent_Identity=30.8139534883721, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=27.6679841897233, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=28.2258064516129, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=32.6530612244898, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788459, Length=253, Percent_Identity=35.5731225296443, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=31.1203319502075, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=29.9595141700405, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=29.8804780876494, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=33.739837398374, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=26.8, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=27.6264591439689, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=27.2357723577236, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787891, Length=138, Percent_Identity=34.0579710144928, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=31.7269076305221, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786812, Length=179, Percent_Identity=32.9608938547486, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=34.412955465587, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=29.8804780876494, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=30.3149606299213, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=31.0344827586207, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=29.9625468164794, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=29.3877551020408, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=30.8270676691729, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=30.5220883534137, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=278, Percent_Identity=28.4172661870504, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=29.6442687747036, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=29.6577946768061, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=29.2134831460674, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.5343511450382, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=27.1698113207547, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=28.6259541984733, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=28.6792452830189, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=28.4132841328413, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=29.6577946768061, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=260, Percent_Identity=28.0769230769231, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=279, Percent_Identity=27.2401433691756, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=252, Percent_Identity=28.1746031746032, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=30.9433962264151, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=30.5343511450382, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=29.7397769516729, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=28.4, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=28.8617886178862, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=31.7269076305221, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=28.3400809716599, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=30.0813008130081, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=31.3492063492063, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644337, Length=191, Percent_Identity=32.4607329842932, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=30.4878048780488, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27322; Mature: 27322

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCHSALHEADILAKHLNQVRMN
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHCC
SAIVLQKELTEPGAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHFLNEADWQYLFAVNV
CEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCCCCCEEEEEEEC
QVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYCQTKAALEMQTRSLARELAPE
CHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCH
IRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKRHGSPDFIAQAVLSLAENTFITGQT
HEEEEECCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEECCEE
LKVDGGRSLTS
EEECCCCCCCC
>Mature Secondary Structure
MNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCHSALHEADILAKHLNQVRMN
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHCC
SAIVLQKELTEPGAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHFLNEADWQYLFAVNV
CEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCCCCCEEEEEEEC
QVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYCQTKAALEMQTRSLARELAPE
CHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCH
IRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKRHGSPDFIAQAVLSLAENTFITGQT
HEEEEECCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEECCEE
LKVDGGRSLTS
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2583128; 9831526 [H]