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The map label for this gene is accC [H]

Identifier: 148360921

GI number: 148360921

Start: 556206

End: 557549

Strand: Reverse

Name: accC [H]

Synonym: LPC_2881

Alternate gene names: 148360921

Gene position: 557549-556206 (Counterclockwise)

Preceding gene: 148360920

Following gene: 148360922

Centisome position: 15.59

GC content: 42.04

Gene sequence:

>1344_bases
ATGCTCAGTAAAATAGTTATTGCTAACCGAGGCGAAATTGCGCTTCGTATATTACGTGCTTGTAAAGAACTCGGCATTCA
GACTGTTGCTGTTCATTCTGATGTAGACAAAGATTTATTGCACGTTCGCCTGGCTGATGAAACCGTATGCATAGGCCCTG
CGCCTGCCCAAAAAAGCTATCTCAATATTCCTGCAATTATATCTGCGGCAGAAATTACTGATGCAGTGGCGATACATCCA
GGTTATGGATTTTTATCAGAAAATGCTGATTTTGCAGATATTGTTGAGCAAAGCGGTTTCCGTTTTATTGGCCCACGCGG
CGACTCCATTCGTCTTATGGGGGATAAAGTTTCCGCGATTGCTGCCATGAAAGCGGCAGGAGTACCCTGTGTTCCCGGTT
CAGACGGTCCTTTAGGAGATGACGACAACAAAAATCTGGAGTTGGCGCGAAAAATTGGTTATCCAATCATTATCAAAGCA
GCCGGCGGCGGTGGTGGACGTGGCATGAGAGTCGTACACAGCGAATCCAATTTACTTAGTGCTATTGCGTTAACCCGAAG
CGAAGCAAAAGCCGCTTTCAATAATCCGATAGTTTACATGGAAAAATTTCTGGAAAATCCTCGCCATGTTGAATTCCAAG
TACTTGGTGATGGGAAAGGGCACGCTATACATTTGGGTGAACGTGATTGCTCGATGCAAAGACGACATCAAAAAGTCGTA
GAAGAAGCCCCGGCTCCAGGAATCACTCCTGAATTAAGGGAAGAAATTGGCGCGTCAGTGATTAAAGCTTGCAAAGAGTT
ACAATACCGAGGTGCTGGAACCTTTGAATTTTTATTTCAAGATGGTTGTTTTTATTTCATCGAAATGAATACGCGGATTC
AGGTTGAGCATCCAGTAACTGAAATGATCACTGGTATTGATTTAATTAAAGAACAAATCAAAATTGCCAGCGATATACCT
CTAACATTAACCCAAAAAGATATTAAATTACGCGGCCATGCTATTGAATGCCGAATCAATGCGGAAGATCCCAGGAATTT
TATGCCCTCTCCTGGAACCATAAAATTACTTCATCAACCAGGAGGTCCAGGCGTTCGTTTTGATTCTCACATCTACAGCA
GCTATGTTGTTCCACCTAATTACGATTCCATGATAGGAAAATTAATAAGTTATGGGGCGACAAGAGCAGAAGCGATTGCC
AGGATGCGTAATGCTCTTGATGAAATTATCATTGATGGCATAAAGACAAATATTGAATTACACCAACGTATTCTTCATGA
CAAATCTTTTATGGAAGGTGGCACAAACATTCACTATCTAGAAAAAATGCTCAAGGATTCATAG

Upstream 100 bases:

>100_bases
AGCAGATCGTGCTGGGAAAATTGTTGAAATCTTGGTAAAAAACGGGGATCCCGTTGAATATGACCAGGCCTTGTTTATTA
TAGAATAGAGGGGCCTGTTT

Downstream 100 bases:

>100_bases
CGTGTGGTTTCAACTAAAAATAGAACATTGTCCTAATGACAAGATTGAAGAAATAACCGAGGAACTCGAAGAATATGGTG
CCTTGTCCATCACGCTTACG

Product: acetyl CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSYLNIPAIISAAEITDAVAIHP
GYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKA
AGGGGGRGMRVVHSESNLLSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQKVV
EEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVTEMITGIDLIKEQIKIASDIP
LTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQPGGPGVRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIA
RMRNALDEIIIDGIKTNIELHQRILHDKSFMEGGTNIHYLEKMLKDS

Sequences:

>Translated_447_residues
MLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSYLNIPAIISAAEITDAVAIHP
GYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKA
AGGGGGRGMRVVHSESNLLSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQKVV
EEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVTEMITGIDLIKEQIKIASDIP
LTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQPGGPGVRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIA
RMRNALDEIIIDGIKTNIELHQRILHDKSFMEGGTNIHYLEKMLKDS
>Mature_447_residues
MLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSYLNIPAIISAAEITDAVAIHP
GYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKA
AGGGGGRGMRVVHSESNLLSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQKVV
EEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVTEMITGIDLIKEQIKIASDIP
LTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQPGGPGVRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIA
RMRNALDEIIIDGIKTNIELHQRILHDKSFMEGGTNIHYLEKMLKDS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=48.5260770975057, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=46.9933184855234, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=449, Percent_Identity=46.9933184855234, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI295821183, Length=449, Percent_Identity=46.9933184855234, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=47.2160356347439, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=47.2160356347439, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=47.2160356347439, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=30.3501945525292, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=30.3501945525292, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=30.2912621359223, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=74.7747747747748, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=177, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.0496613995485, Blast_Score=390, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=45.7013574660633, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=44.6428571428571, Blast_Score=350, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=28.2208588957055, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=27.0428015564202, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=27.0428015564202, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.0835214446953, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.5357142857143, Blast_Score=328, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.4196428571429, Blast_Score=328, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=31.7919075144509, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=472, Percent_Identity=33.2627118644068, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24651757, Length=423, Percent_Identity=46.3356973995272, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=46.2053571428571, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=385, Percent_Identity=45.4545454545455, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=28.8270377733598, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=28.8270377733598, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=28.8270377733598, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=28.8270377733598, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48952; Mature: 48952

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNIPAIISAAEITDAVAIHPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAI
CCCHHHEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEEEECCHHHHH
AAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKAAGGGGGRGMRVVHSESNLLS
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHH
AIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCEEEECCCHH
EMITGIDLIKEQIKIASDIPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQP
HHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEECC
GGPGVRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIARMRNALDEIIIDGIKTNIEL
CCCCCEECCHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
HQRILHDKSFMEGGTNIHYLEKMLKDS
HHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNIPAIISAAEITDAVAIHPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAI
CCCHHHEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEEEECCHHHHH
AAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKAAGGGGGRGMRVVHSESNLLS
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHH
AIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCEEEECCCHH
EMITGIDLIKEQIKIASDIPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQP
HHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEECC
GGPGVRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIARMRNALDEIIIDGIKTNIEL
CCCCCEECCHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
HQRILHDKSFMEGGTNIHYLEKMLKDS
HHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]