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The map label for this gene is uppS [H]

Identifier: 148360882

GI number: 148360882

Start: 595584

End: 596300

Strand: Direct

Name: uppS [H]

Synonym: LPC_2842

Alternate gene names: 148360882

Gene position: 595584-596300 (Clockwise)

Preceding gene: 148360888

Following gene: 148360881

Centisome position: 16.65

GC content: 39.33

Gene sequence:

>717_bases
TTGAATCATAAATTACCTCAACACATTGCCGTTGTCATGGATGGAAACGGGCGTTGGGCTGAAAGCCGCGGTTTGCCCCG
TGTAGAGGGACACAAAGCGGGCCTTGACTCAGTTAAAAAGATTATCAATTGTTGCCTGGAAAAAAAAATTTCCTGCTTAA
GCCTGTTTGCATTTAGCTCTGAAAATTGGTCAAGACCAGTGACAGAAGTCAATTTTCTTATGGAGTTGTTTTTGGAGGCT
TTGCGAAAAGAGATAGACGATTTAAACCAGCATGGAATACGGTTAAAGTTTACTGGCGATAGAGAACCTTTGTCTCAAGT
ATTACAAAAGCAAATGTGTGATGCGGAAGCTCTTACCAAGAATAATCAACAATTAATTCTCAATGTTGTTGTGAATTATG
GTGGGAAATGGGATATAGTGACGGCGGCTAAAAAATTAATACACGCTGTTTTAGATGGGAAGTTGGCATGTGATGAAATC
AATGAGGCAGTATTCGCTCAATTTCTTGATACGAGTGGTATGCCGGAACCCGATCTGTTTATTCGAACTAGTGGTGAATT
AAGGATAAGTAATTTTTTTCTTTGGCAGTTAGCTTATACTGAGCTGTATTTTACTGATGTTCATTGGCCTGATTTCAATG
AACATGAGTTTGAATTGGCATTGACTTCTTTTGCCAAGCGGGCAAGAAGGTTTGGGCAAATTTCACAATCTGAATAA

Upstream 100 bases:

>100_bases
TGTTTCATAAACAAGGTCAATTGATTTCTTAAGTAGTACTTAAATTTTTATCTCAAAGAGGTTAGACTATGCATCATTTT
TATTAGTCGGATAAGTTGTT

Downstream 100 bases:

>100_bases
AGGTAAAACCATGTTTATGCAACGATTGATCACGACATTAATATTAGCGCCCCCTGGTTTTGCTAGCTAATTTTTAATGC
CCCTTCCTGGATTTTATGGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSSENWSRPVTEVNFLMELFLEA
LRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMCDAEALTKNNQQLILNVVVNYGGKWDIVTAAKKLIHAVLDGKLACDEI
NEAVFAQFLDTSGMPEPDLFIRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALTSFAKRARRFGQISQSE

Sequences:

>Translated_238_residues
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSSENWSRPVTEVNFLMELFLEA
LRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMCDAEALTKNNQQLILNVVVNYGGKWDIVTAAKKLIHAVLDGKLACDEI
NEAVFAQFLDTSGMPEPDLFIRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALTSFAKRARRFGQISQSE
>Mature_238_residues
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSSENWSRPVTEVNFLMELFLEA
LRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMCDAEALTKNNQQLILNVVVNYGGKWDIVTAAKKLIHAVLDGKLACDEI
NEAVFAQFLDTSGMPEPDLFIRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALTSFAKRARRFGQISQSE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=35.8490566037736, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=35.8490566037736, Blast_Score=141, Evalue=5e-34,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=49.1525423728814, Blast_Score=241, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=41.3145539906103, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=226, Percent_Identity=35.3982300884956, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=30.2325581395349, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=36.283185840708, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27203; Mature: 27203

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSS
CCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ENWSRPVTEVNFLMELFLEALRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMCDAEALTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHC
NNQQLILNVVVNYGGKWDIVTAAKKLIHAVLDGKLACDEINEAVFAQFLDTSGMPEPDLF
CCHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEE
IRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALTSFAKRARRFGQISQSE
EEECCCEEEHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNHKLPQHIAVVMDGNGRWAESRGLPRVEGHKAGLDSVKKIINCCLEKKISCLSLFAFSS
CCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ENWSRPVTEVNFLMELFLEALRKEIDDLNQHGIRLKFTGDREPLSQVLQKQMCDAEALTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHC
NNQQLILNVVVNYGGKWDIVTAAKKLIHAVLDGKLACDEINEAVFAQFLDTSGMPEPDLF
CCHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEE
IRTSGELRISNFFLWQLAYTELYFTDVHWPDFNEHEFELALTSFAKRARRFGQISQSE
EEECCCEEEHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA