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The map label for this gene is lpxD [H]

Identifier: 148360877

GI number: 148360877

Start: 601594

End: 602625

Strand: Direct

Name: lpxD [H]

Synonym: LPC_2837

Alternate gene names: 148360877

Gene position: 601594-602625 (Clockwise)

Preceding gene: 148360878

Following gene: 148360876

Centisome position: 16.82

GC content: 42.83

Gene sequence:

>1032_bases
TTGGCGGATGCGTTGCTAACCTTAGAGGAACTGGCAAACTATTTAAATGGCGTCTGGCATGGCAATGCCAATCACGCCAT
TTTTAGTCTATCCTCGTTGGCTCGAGCTTCATCTAAGGATCTTGCGTATTTTGATAATCCCTTATTGCAGTCTGTCTTAA
ACTCTACCAGAGCAGGTGCTGTTTTATTAAAGCCCGAGCACAAAGATTGGTGTCCTGTGAACTGTATTGTAGTTCCCAAT
CCGTCAGAAGCAATGTTTAAAGCAGCAAAGAGCCTGCCTCACCTTGCTACCAATGTTTGCGGAATTCATCCTACAGCTCA
AATCCACAAATCTGCCCAAATAGGTCAATACGTATCAGTTGGCGCTAACAGCGTGATTGGTGAAAATGTACAATTGGATG
ATTACGTAACTATTGGCTCTAATACGACCATTGAATCTTCAGTACTGATTGGCAGAGGGAGTCAGCTGGGTTCTGGAGCA
ATAATTCATTCTGGTACAGTTTTGGGCCAATCTGTAATTATTGATTCTGGGTGTATTGTTGGTGCTGCCCCGTTTAATTG
CTACAAGGAACATGGTGTCTGGCAACAAGCACCAAACTTTGGTGGAGTTGTAATAGGCCAAAGAACTCAAATCGGTGCAA
ATACAGTAATTCACAGAGGCTCCATTGGCGATACTTATTTAGGCGATGGAGTCTGTATAGACAGTTTAGTACTCATCGCG
CATGATGTTTATATAGGGAATAACACTGCTATTGCAGGTTCTGCTGCAATTGGTGCTTTAGTGCAAATAGGCAGTGATTG
TATCATAGGTGGGGCAAGTTGCCTTGCAGCGAACATTCGTTTGACTAATGATGTAGTAATAACAGGAATGTCTACAGTGA
CAAAATCCATCGCTCGCCCCGGGATTTATTCTTCGGGAACGACGGTTCACGATCATCGCAAGTGGCGTCGTAACACAGCA
CGGTTCAGGCATTTGGATGACTACATTACAAAGCTGATAACAATAGAAAAAAAATTGAATAATAACAACTAA

Upstream 100 bases:

>100_bases
AAGGATGAGAAGTACGATATTATTGTTCAGAAAGATGCAGCGCCCTTCAGCAGCGAATCTCTTGATGTAACAGATAAAGT
TATCAAAGCAATTAATTAAT

Downstream 100 bases:

>100_bases
TTATGTTTTATCAATTTGAAGTAACATTATTTTTGAAATTTTTAATTGATTAGAATGAGCTAAACCAAGATAATGAGCCA
TTTTGTAATGCAATAGGCGA

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N- acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MADALLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLKPEHKDWCPVNCIVVPN
PSEAMFKAAKSLPHLATNVCGIHPTAQIHKSAQIGQYVSVGANSVIGENVQLDDYVTIGSNTTIESSVLIGRGSQLGSGA
IIHSGTVLGQSVIIDSGCIVGAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIA
HDVYIGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYSSGTTVHDHRKWRRNTA
RFRHLDDYITKLITIEKKLNNNN

Sequences:

>Translated_343_residues
MADALLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLKPEHKDWCPVNCIVVPN
PSEAMFKAAKSLPHLATNVCGIHPTAQIHKSAQIGQYVSVGANSVIGENVQLDDYVTIGSNTTIESSVLIGRGSQLGSGA
IIHSGTVLGQSVIIDSGCIVGAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIA
HDVYIGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYSSGTTVHDHRKWRRNTA
RFRHLDDYITKLITIEKKLNNNN
>Mature_342_residues
ADALLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGAVLLKPEHKDWCPVNCIVVPNP
SEAMFKAAKSLPHLATNVCGIHPTAQIHKSAQIGQYVSVGANSVIGENVQLDDYVTIGSNTTIESSVLIGRGSQLGSGAI
IHSGTVLGQSVIIDSGCIVGAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIAH
DVYIGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARPGIYSSGTTVHDHRKWRRNTAR
FRHLDDYITKLITIEKKLNNNN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=338, Percent_Identity=34.6153846153846, Blast_Score=211, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 36263; Mature: 36131

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADALLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGA
CCCHHHHHHHHHHHHCCEEECCCCCEEEEHHHHHHCCCCCCHHHCCHHHHHHHCCCCCCE
VLLKPEHKDWCPVNCIVVPNPSEAMFKAAKSLPHLATNVCGIHPTAQIHKSAQIGQYVSV
EEECCCCCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHCCHHHC
GANSVIGENVQLDDYVTIGSNTTIESSVLIGRGSQLGSGAIIHSGTVLGQSVIIDSGCIV
CCCCCCCCCEEECCEEEECCCCEEECEEEEECCCCCCCCEEEECCCCCCCEEEEECCCEE
GAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIA
ECCCCHHHHHCCCHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHEEHH
HDVYIGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARP
EEEEECCCCEECCHHHHHHHHHCCCCEEECCHHHEEEEEEEECCEEEECHHHHHHHHHCC
GIYSSGTTVHDHRKWRRNTARFRHLDDYITKLITIEKKLNNNN
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADALLTLEELANYLNGVWHGNANHAIFSLSSLARASSKDLAYFDNPLLQSVLNSTRAGA
CCHHHHHHHHHHHHCCEEECCCCCEEEEHHHHHHCCCCCCHHHCCHHHHHHHCCCCCCE
VLLKPEHKDWCPVNCIVVPNPSEAMFKAAKSLPHLATNVCGIHPTAQIHKSAQIGQYVSV
EEECCCCCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHCCHHHC
GANSVIGENVQLDDYVTIGSNTTIESSVLIGRGSQLGSGAIIHSGTVLGQSVIIDSGCIV
CCCCCCCCCEEECCEEEECCCCEEECEEEEECCCCCCCCEEEECCCCCCCEEEEECCCEE
GAAPFNCYKEHGVWQQAPNFGGVVIGQRTQIGANTVIHRGSIGDTYLGDGVCIDSLVLIA
ECCCCHHHHHCCCHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHEEHH
HDVYIGNNTAIAGSAAIGALVQIGSDCIIGGASCLAANIRLTNDVVITGMSTVTKSIARP
EEEEECCCCEECCHHHHHHHHHCCCCEEECCHHHEEEEEEEECCEEEECHHHHHHHHHCC
GIYSSGTTVHDHRKWRRNTARFRHLDDYITKLITIEKKLNNNN
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA