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The map label for this gene is prs [H]

Identifier: 148360800

GI number: 148360800

Start: 677189

End: 678136

Strand: Reverse

Name: prs [H]

Synonym: LPC_2756

Alternate gene names: 148360800

Gene position: 678136-677189 (Counterclockwise)

Preceding gene: 148360799

Following gene: 148360803

Centisome position: 18.96

GC content: 42.51

Gene sequence:

>948_bases
ATGTCCACGATGATGATTTTTACAGGGAATGCTAACCCTGAATTAGCACTAAAAATTTCCTCACATTTGCAAATACCTAT
TGGCAAAGCCACCGTTGGTACCTTCAGCGATGGAGAGACTATGGTTGAGATTTTGGAAAATGTCCGAGGTAAAGATGTTT
TTGTCCTCCAATCAACTTGTGCGCCTGCAAATAATAATTTAATGGAATTGCTGATTATGGCGGATGCCCTGAGAAGATCA
TCTGCTGGTCGTATTACAGCTGTAGTTCCTTATTTTGGCTACGCACGCCAAGATAGGCGAGTGCGCTCCGCCCGTGTTCC
TATCACAGCTAAAGTGGTAGCAGACATGATGGCTTCCGTTGGAATTTGTCGGGTCCTTACTGTTGATTTGCACGCGGATC
AAATACAGGGTTTCTTTTATATGCCGGTCGATAACGTATACTCAACTCCGGTATTGCTGGAAGATATAACCAAACAAAAA
TTAAACAACATCATGATCGTATCGCCAGATGTCGGTGGGGTTGTTCGTGCCAGAGCAGTTGCTAAAAGACTGAATGACGC
TGAGCTGTCGATTATTGATAAACGCCGTAGTGGGCCAAATAAATCAGAAGTAATGCACATTATTGGTGAGCCCGCCAATA
AAAACTGTATTATTGTAGACGACATAGTAGATACTGCTGGAACACTTTGTACGGCTGCTCATGAATTAAAGAAAAACGGA
GCAAAAAGCGTCAGAGCCTACATTACACATCCTGTGTTGTCAGGCCCCGCAGTTAACAATATTAAACATTCAGGTCTTGA
TGAGGTGGTAGTAACTGATACCATTCCTTTATCAGCCGAAGCACAAAACTGTGAAAAAATCAGAGTGGTCAGTCTTGCTG
ATATGTTAGCTCAAGCAATCAAACGAGTAAATGTTGAGGAGTCAGTAAGCTCCATGTTTGCTGAATAA

Upstream 100 bases:

>100_bases
TGCGTACTTCGTATCGCTCAAATAATAATAATATCTTTTTGGCTGTCTTCTGCTATGTGTTTAAGTTATGTGATTAACCT
AAATCTAAGGCTTTTGACAC

Downstream 100 bases:

>100_bases
AATGAAATATTCTTTGATAATAAAAAGGGAGCTAAGGCTCCCTTTTTATTATCAATCTTTCTTAATCCCTTGTACCAACG
TATTTATCATCAAAATAACG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSTMMIFTGNANPELALKISSHLQIPIGKATVGTFSDGETMVEILENVRGKDVFVLQSTCAPANNNLMELLIMADALRRS
SAGRITAVVPYFGYARQDRRVRSARVPITAKVVADMMASVGICRVLTVDLHADQIQGFFYMPVDNVYSTPVLLEDITKQK
LNNIMIVSPDVGGVVRARAVAKRLNDAELSIIDKRRSGPNKSEVMHIIGEPANKNCIIVDDIVDTAGTLCTAAHELKKNG
AKSVRAYITHPVLSGPAVNNIKHSGLDEVVVTDTIPLSAEAQNCEKIRVVSLADMLAQAIKRVNVEESVSSMFAE

Sequences:

>Translated_315_residues
MSTMMIFTGNANPELALKISSHLQIPIGKATVGTFSDGETMVEILENVRGKDVFVLQSTCAPANNNLMELLIMADALRRS
SAGRITAVVPYFGYARQDRRVRSARVPITAKVVADMMASVGICRVLTVDLHADQIQGFFYMPVDNVYSTPVLLEDITKQK
LNNIMIVSPDVGGVVRARAVAKRLNDAELSIIDKRRSGPNKSEVMHIIGEPANKNCIIVDDIVDTAGTLCTAAHELKKNG
AKSVRAYITHPVLSGPAVNNIKHSGLDEVVVTDTIPLSAEAQNCEKIRVVSLADMLAQAIKRVNVEESVSSMFAE
>Mature_314_residues
STMMIFTGNANPELALKISSHLQIPIGKATVGTFSDGETMVEILENVRGKDVFVLQSTCAPANNNLMELLIMADALRRSS
AGRITAVVPYFGYARQDRRVRSARVPITAKVVADMMASVGICRVLTVDLHADQIQGFFYMPVDNVYSTPVLLEDITKQKL
NNIMIVSPDVGGVVRARAVAKRLNDAELSIIDKRRSGPNKSEVMHIIGEPANKNCIIVDDIVDTAGTLCTAAHELKKNGA
KSVRAYITHPVLSGPAVNNIKHSGLDEVVVTDTIPLSAEAQNCEKIRVVSLADMLAQAIKRVNVEESVSSMFAE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=43.5331230283912, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=43.2601880877743, Blast_Score=277, Evalue=7e-75,
Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=44.4794952681388, Blast_Score=277, Evalue=7e-75,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=43.5331230283912, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=35.6521739130435, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=35.9649122807018, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=28.1879194630872, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=28.1879194630872, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=28.1879194630872, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=28.1879194630872, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=63.5782747603834, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI25149168, Length=318, Percent_Identity=43.3962264150943, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17554702, Length=318, Percent_Identity=43.3962264150943, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71989924, Length=318, Percent_Identity=43.3962264150943, Blast_Score=267, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17554704, Length=313, Percent_Identity=43.7699680511182, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=34.7058823529412, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=41.0094637223975, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=40.6940063091483, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321776, Length=302, Percent_Identity=43.7086092715232, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6322667, Length=200, Percent_Identity=39.5, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=43.2432432432432, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=44.3037974683544, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=41.4201183431953, Blast_Score=260, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=33.7078651685393, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=33.7078651685393, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=33.4269662921348, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=33.4269662921348, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24651462, Length=375, Percent_Identity=32, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24651464, Length=375, Percent_Identity=32, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI45552010, Length=375, Percent_Identity=32, Blast_Score=187, Evalue=9e-48,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34129; Mature: 33998

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMMIFTGNANPELALKISSHLQIPIGKATVGTFSDGETMVEILENVRGKDVFVLQSTC
CCEEEEEECCCCCEEEEEEECCEEEEECCEEECCCCCCHHHHHHHHCCCCCEEEEEECCC
APANNNLMELLIMADALRRSSAGRITAVVPYFGYARQDRRVRSARVPITAKVVADMMASV
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GICRVLTVDLHADQIQGFFYMPVDNVYSTPVLLEDITKQKLNNIMIVSPDVGGVVRARAV
CEEEEEEEEEEHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHH
AKRLNDAELSIIDKRRSGPNKSEVMHIIGEPANKNCIIVDDIVDTAGTLCTAAHELKKNG
HHHCCCCCEEEEECCCCCCCHHHEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHCC
AKSVRAYITHPVLSGPAVNNIKHSGLDEVVVTDTIPLSAEAQNCEKIRVVSLADMLAQAI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHH
KRVNVEESVSSMFAE
HHCCHHHHHHHHHCC
>Mature Secondary Structure 
STMMIFTGNANPELALKISSHLQIPIGKATVGTFSDGETMVEILENVRGKDVFVLQSTC
CEEEEEECCCCCEEEEEEECCEEEEECCEEECCCCCCHHHHHHHHCCCCCEEEEEECCC
APANNNLMELLIMADALRRSSAGRITAVVPYFGYARQDRRVRSARVPITAKVVADMMASV
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GICRVLTVDLHADQIQGFFYMPVDNVYSTPVLLEDITKQKLNNIMIVSPDVGGVVRARAV
CEEEEEEEEEEHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHH
AKRLNDAELSIIDKRRSGPNKSEVMHIIGEPANKNCIIVDDIVDTAGTLCTAAHELKKNG
HHHCCCCCEEEEECCCCCCCHHHEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHCC
AKSVRAYITHPVLSGPAVNNIKHSGLDEVVVTDTIPLSAEAQNCEKIRVVSLADMLAQAI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHH
KRVNVEESVSSMFAE
HHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA