Click here to switch to the map view.

The map label for this gene is fthC [C]

Identifier: 148360759

GI number: 148360759

Start: 719039

End: 719620

Strand: Reverse

Name: fthC [C]

Synonym: LPC_2709

Alternate gene names: 148360759

Gene position: 719620-719039 (Counterclockwise)

Preceding gene: 148360756

Following gene: 148360761

Centisome position: 20.12

GC content: 42.61

Gene sequence:

>582_bases
ATGTCAGACCAATATAAAGTTGCTCTAAGAAATACCATAAAACAGGTAAGATCCAAGCTTTCTGTATCCTACAGAACAGC
ATCTTCCAATCAAATTTGTACTCGTATCCGCTCGCTGGAACAATACAGGCAAGCAAAGCGAATAGCCTTGTACTTTGCCG
TTAATGGAGAAGTTGATTTAACATTTCTGTGGAAAAGCGCGCCCCTCCAGGGGAAGTATTGTTATTTTCCGGTATTAAAT
AATGATTCCACTCTTTCTTTTTTACCAGCCACCCCCAGCACCCCTTTTAAAACGAATAAATACGATATACTGGAACCGGA
CGTTGATATTGAGTTGGCCTTGCCTGTTGATGAATTAGACTTGATTATCATGCCTCTGGTTGCTTTTGATGCGCACTGTA
CTCGTTTGGGTATGGGCTCAGGCTACTATGATCGCACCTTGGCTAATAAATCAAAAGCGCATCTCTTGGGAGTCGCCTAC
CAATTTCAAAGGGTTGATTACATAGAACCACGCCCTTGGGATGTTCCCCTGGATGCCGTAATAACTCAAAAAGCTATTTA
TTGGCGAAACCCCTTGGCCTAA

Upstream 100 bases:

>100_bases
AATCACCCAATGCATAAAACAACATATTGATACCTGGAAACACTTGAACTTTAAGCCCAATCCATCTAATAATAAAAAAG
AATATTAGTGATACCAAATC

Downstream 100 bases:

>100_bases
AATGACATTCTATAGAGCGTCTGTACCAACTTCCCCTGTTCTAACCCTCACTACCTGTTCCAAAGCATAAACAAAAATCT
TGCCATCACCAATTTTACCA

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSDQYKVALRNTIKQVRSKLSVSYRTASSNQICTRIRSLEQYRQAKRIALYFAVNGEVDLTFLWKSAPLQGKYCYFPVLN
NDSTLSFLPATPSTPFKTNKYDILEPDVDIELALPVDELDLIIMPLVAFDAHCTRLGMGSGYYDRTLANKSKAHLLGVAY
QFQRVDYIEPRPWDVPLDAVITQKAIYWRNPLA

Sequences:

>Translated_193_residues
MSDQYKVALRNTIKQVRSKLSVSYRTASSNQICTRIRSLEQYRQAKRIALYFAVNGEVDLTFLWKSAPLQGKYCYFPVLN
NDSTLSFLPATPSTPFKTNKYDILEPDVDIELALPVDELDLIIMPLVAFDAHCTRLGMGSGYYDRTLANKSKAHLLGVAY
QFQRVDYIEPRPWDVPLDAVITQKAIYWRNPLA
>Mature_192_residues
SDQYKVALRNTIKQVRSKLSVSYRTASSNQICTRIRSLEQYRQAKRIALYFAVNGEVDLTFLWKSAPLQGKYCYFPVLNN
DSTLSFLPATPSTPFKTNKYDILEPDVDIELALPVDELDLIIMPLVAFDAHCTRLGMGSGYYDRTLANKSKAHLLGVAYQ
FQRVDYIEPRPWDVPLDAVITQKAIYWRNPLA

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=193, Percent_Identity=26.9430051813472, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1789278, Length=179, Percent_Identity=35.195530726257, Blast_Score=110, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: NA

Molecular weight: Translated: 22076; Mature: 21944

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQYKVALRNTIKQVRSKLSVSYRTASSNQICTRIRSLEQYRQAKRIALYFAVNGEVDL
CCCCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHCEEEEEEEECCCEEE
TFLWKSAPLQGKYCYFPVLNNDSTLSFLPATPSTPFKTNKYDILEPDVDIELALPVDELD
EEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCHHH
LIIMPLVAFDAHCTRLGMGSGYYDRTLANKSKAHLLGVAYQFQRVDYIEPRPWDVPLDAV
HHHHHHHHHCCHHHEECCCCCCCHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHH
ITQKAIYWRNPLA
HHHHHHEECCCCC
>Mature Secondary Structure 
SDQYKVALRNTIKQVRSKLSVSYRTASSNQICTRIRSLEQYRQAKRIALYFAVNGEVDL
CCCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHCEEEEEEEECCCEEE
TFLWKSAPLQGKYCYFPVLNNDSTLSFLPATPSTPFKTNKYDILEPDVDIELALPVDELD
EEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCHHH
LIIMPLVAFDAHCTRLGMGSGYYDRTLANKSKAHLLGVAYQFQRVDYIEPRPWDVPLDAV
HHHHHHHHHCCHHHEECCCCCCCHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHH
ITQKAIYWRNPLA
HHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]