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The map label for this gene is comA [H]

Identifier: 148360720

GI number: 148360720

Start: 757397

End: 759604

Strand: Reverse

Name: comA [H]

Synonym: LPC_2668

Alternate gene names: 148360720

Gene position: 759604-757397 (Counterclockwise)

Preceding gene: 148360719

Following gene: 148360723

Centisome position: 21.24

GC content: 40.31

Gene sequence:

>2208_bases
ATGGAAATTTATTGCTTTTTAATAGGCGTACTTTATGCCTATACCTATAATATTTATCTAACTATTGCGATTCCTTTACT
CTTTTATATCACACCAAGATATCCAATTGTCCTGTTCTTCATCGCCGGGTGCGGCTTTGCCCTGATTCATCAGTGGATTG
TATCTCCCAAGGGCATGCCTGATACGCAAGTAATCACTCAAGCCCAATTGGAAGGAACAATTGCTTCCATCCCCATGCAA
CGTCCTAACAAAACTCAATTCCATTTTGCAATTGAAAAAATTAATAATAACCCTGCTCAAGGCTTGATCCAATTAAACTG
GTATAACAAACCTCCTGTCTTACGAGCCGGTCAGCGATGGCAACTTTCAGTGAAACTAAAAAAACCTCGTAATTTCCGCA
ACCCAGGAGGTTTTAATTATGTACGTTACCTGGCGGCTCGTCATATCCATTGGACTGGTTATATTCGTTATGGGAATAAT
AAGCTAATTAGCAATCAACCCCCTTCTTTCAGTTGGTTAACACTGCGTGAAAAAATAGGGGATGCTTTGACCAAACTGGC
ACCGAATACAGAAACGGCAGGCATCATCGAAGCATTGACGTTAAATGTTACTCACCATATCAGTTCAGAACATTGGAACT
TGTTCCGAAGAACAGGAACGGTACATTTATTCGGGATTTCAGGGGAGCACATCGCTCTGGTCTCCTGCATTTTCTTTATA
GTGATAAGATGGATTTGGTCAATGAGCTATCGTTGCTGTTTGTTCTTACCGGCCCATACCATAGCGAGTATCGGTGGGCT
ACTGGCCGCCTTGCCCTATGCTTTTTTAGCCGGGTTTGAACCTCCTGTACAGCGTGCTTTAATTGGTTGTGTACTTTACA
CAATATACGCCATAGGAAAACAACGTTTTACACCATGGCAAATATGGAGATACGCCTTATTTTTAGTCTTGTGTATTGAA
CCCCATGCCGTATTCCTGCAAGGTTTTTATTTTTCATTTCTTGCTGTGGCCTGTCTTCTATTGACGCACCAACGTTGGCC
ACTGAAAAATTATAAAAAAACACTGACATTACAATTAAGCTGCCTCATTGGATTGATGCCCTTGACTCTCCATTGGTACT
CCTATGGTTCTATTAATGGATTCCTTGCCAATTTATTCTCCATACCTTTAGTCAGCTTTCTGATAGTACCCTTGGCTTTA
ATGACTATGATAACGAGTCCGCTTCATTGGTCCTGGATATTGATGAAACCATTGGCATGGCTTGTTGCCCTGTTACTGCA
AGGACTAACGTATGTTGAGCAAATAGCAGGGATTAATATCACCTGGTCCATCACCTCGGTAACAATGATGCTCGCTATGA
CAGCAGGTCTGTTTTTAAGGGTATTATTACCTGTCAAGCCATTCAAACACTTGGCTATCCTTTGGATTATCCTTCCCTTA
TTTCCGCCTCGTACTGCAATTTATCCAGGGGAAGCATTAATTAATATTTTGGATGTTGGGCAAGGACTGGCTGTTGCGAT
ACAAACGCAACATCATGTTTTACTCTACGATACGGGAGATTCCTATTTTCAGGGGAGTGATTTAGGGCAAATGGCGATAA
TACCCTTTTTCAGGTCAATTGGAATAAAAACAATTGACAAAATAGTAATAAGCCATCCTGATAAAGATCATAAGGGCGGA
TTAAATTCCCTTGAAAAAGAGATGCAAGTCAATCAATTAATAGTGAATGATCCCTATTTTTATAAACGTGGAAGTAATTG
TCATTCATACCCACAATGGCAATGGGATGGGGTGAGTTTTCGTTTTTTACCCATCAAGGAATCTTTCACTAAAAAAAATA
ACAATTCTTGTATCTTACAGGTAAGTAATTCAGCTGGCAGGGTTTTATTAACGGGAGATATTGAAAAAGCGGCTGAAGAG
TACCTGGTAAGAAACTACGGCAGTCAGCTGGCATCCGAGATTTTAGTTGTGCCTCATCATGGGAGTAAAACGTCTTCATC
CTATCGATTTTTGCTGGAAGTAAACCCGCTTTATGCCATTGCATCCTTAGGATTTGATAATCGTTTCAAATTTCCACATT
CTAAAACTTTGCAAAGCATGAAAACATTAGATATCACTTTTTTTAGAACAGACGAATGCGGAATGGCAGCAATCAAACTA
CCTGCATCAGGTCAAGTTCACAGACCAAGTTGTATGCAGGCTAATTGA

Upstream 100 bases:

>100_bases
CAGAATGCTGGAATCCCGGTTAATACTGTAAAAAATTCTTTACACAAAGGATTCAATTCGAGTAGATTTGCCAGTAAGGG
AAAGTCCAACTTAATTTGAA

Downstream 100 bases:

>100_bases
ATAGATGCATTGGCTGGCCAATGTATTTTACTTCATCATTCCAAGTGCTATACCTCTAAGTCTTATTAGCCGATTGGAAC
CACCAGTCACTCAATGGTGT

Product: DNA uptake/competence protein ComA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MEIYCFLIGVLYAYTYNIYLTIAIPLLFYITPRYPIVLFFIAGCGFALIHQWIVSPKGMPDTQVITQAQLEGTIASIPMQ
RPNKTQFHFAIEKINNNPAQGLIQLNWYNKPPVLRAGQRWQLSVKLKKPRNFRNPGGFNYVRYLAARHIHWTGYIRYGNN
KLISNQPPSFSWLTLREKIGDALTKLAPNTETAGIIEALTLNVTHHISSEHWNLFRRTGTVHLFGISGEHIALVSCIFFI
VIRWIWSMSYRCCLFLPAHTIASIGGLLAALPYAFLAGFEPPVQRALIGCVLYTIYAIGKQRFTPWQIWRYALFLVLCIE
PHAVFLQGFYFSFLAVACLLLTHQRWPLKNYKKTLTLQLSCLIGLMPLTLHWYSYGSINGFLANLFSIPLVSFLIVPLAL
MTMITSPLHWSWILMKPLAWLVALLLQGLTYVEQIAGINITWSITSVTMMLAMTAGLFLRVLLPVKPFKHLAILWIILPL
FPPRTAIYPGEALINILDVGQGLAVAIQTQHHVLLYDTGDSYFQGSDLGQMAIIPFFRSIGIKTIDKIVISHPDKDHKGG
LNSLEKEMQVNQLIVNDPYFYKRGSNCHSYPQWQWDGVSFRFLPIKESFTKKNNNSCILQVSNSAGRVLLTGDIEKAAEE
YLVRNYGSQLASEILVVPHHGSKTSSSYRFLLEVNPLYAIASLGFDNRFKFPHSKTLQSMKTLDITFFRTDECGMAAIKL
PASGQVHRPSCMQAN

Sequences:

>Translated_735_residues
MEIYCFLIGVLYAYTYNIYLTIAIPLLFYITPRYPIVLFFIAGCGFALIHQWIVSPKGMPDTQVITQAQLEGTIASIPMQ
RPNKTQFHFAIEKINNNPAQGLIQLNWYNKPPVLRAGQRWQLSVKLKKPRNFRNPGGFNYVRYLAARHIHWTGYIRYGNN
KLISNQPPSFSWLTLREKIGDALTKLAPNTETAGIIEALTLNVTHHISSEHWNLFRRTGTVHLFGISGEHIALVSCIFFI
VIRWIWSMSYRCCLFLPAHTIASIGGLLAALPYAFLAGFEPPVQRALIGCVLYTIYAIGKQRFTPWQIWRYALFLVLCIE
PHAVFLQGFYFSFLAVACLLLTHQRWPLKNYKKTLTLQLSCLIGLMPLTLHWYSYGSINGFLANLFSIPLVSFLIVPLAL
MTMITSPLHWSWILMKPLAWLVALLLQGLTYVEQIAGINITWSITSVTMMLAMTAGLFLRVLLPVKPFKHLAILWIILPL
FPPRTAIYPGEALINILDVGQGLAVAIQTQHHVLLYDTGDSYFQGSDLGQMAIIPFFRSIGIKTIDKIVISHPDKDHKGG
LNSLEKEMQVNQLIVNDPYFYKRGSNCHSYPQWQWDGVSFRFLPIKESFTKKNNNSCILQVSNSAGRVLLTGDIEKAAEE
YLVRNYGSQLASEILVVPHHGSKTSSSYRFLLEVNPLYAIASLGFDNRFKFPHSKTLQSMKTLDITFFRTDECGMAAIKL
PASGQVHRPSCMQAN
>Mature_735_residues
MEIYCFLIGVLYAYTYNIYLTIAIPLLFYITPRYPIVLFFIAGCGFALIHQWIVSPKGMPDTQVITQAQLEGTIASIPMQ
RPNKTQFHFAIEKINNNPAQGLIQLNWYNKPPVLRAGQRWQLSVKLKKPRNFRNPGGFNYVRYLAARHIHWTGYIRYGNN
KLISNQPPSFSWLTLREKIGDALTKLAPNTETAGIIEALTLNVTHHISSEHWNLFRRTGTVHLFGISGEHIALVSCIFFI
VIRWIWSMSYRCCLFLPAHTIASIGGLLAALPYAFLAGFEPPVQRALIGCVLYTIYAIGKQRFTPWQIWRYALFLVLCIE
PHAVFLQGFYFSFLAVACLLLTHQRWPLKNYKKTLTLQLSCLIGLMPLTLHWYSYGSINGFLANLFSIPLVSFLIVPLAL
MTMITSPLHWSWILMKPLAWLVALLLQGLTYVEQIAGINITWSITSVTMMLAMTAGLFLRVLLPVKPFKHLAILWIILPL
FPPRTAIYPGEALINILDVGQGLAVAIQTQHHVLLYDTGDSYFQGSDLGQMAIIPFFRSIGIKTIDKIVISHPDKDHKGG
LNSLEKEMQVNQLIVNDPYFYKRGSNCHSYPQWQWDGVSFRFLPIKESFTKKNNNSCILQVSNSAGRVLLTGDIEKAAEE
YLVRNYGSQLASEILVVPHHGSKTSSSYRFLLEVNPLYAIASLGFDNRFKFPHSKTLQSMKTLDITFFRTDECGMAAIKL
PASGQVHRPSCMQAN

Specific function: Unknown

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, N.gonorrhoeae ComA, and H.influenzae Rec2 [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=654, Percent_Identity=30.8868501529052, Blast_Score=248, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 83330; Mature: 83330

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYCFLIGVLYAYTYNIYLTIAIPLLFYITPRYPIVLFFIAGCGFALIHQWIVSPKGMP
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCC
DTQVITQAQLEGTIASIPMQRPNKTQFHFAIEKINNNPAQGLIQLNWYNKPPVLRAGQRW
CHHHHHHHHHCCHHEECCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEE
QLSVKLKKPRNFRNPGGFNYVRYLAARHIHWTGYIRYGNNKLISNQPPSFSWLTLREKIG
EEEEEEECCCCCCCCCCHHHHHHHHHHCEEEEEEEEECCCEEECCCCCCCEEEHHHHHHH
DALTKLAPNTETAGIIEALTLNVTHHISSEHWNLFRRTGTVHLFGISGEHIALVSCIFFI
HHHHHCCCCCCCCHHHHHEEEEHHECCCCHHHHHHEECCEEEEEECCCCHHHHHHHHHHH
VIRWIWSMSYRCCLFLPAHTIASIGGLLAALPYAFLAGFEPPVQRALIGCVLYTIYAIGK
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
QRFTPWQIWRYALFLVLCIEPHAVFLQGFYFSFLAVACLLLTHQRWPLKNYKKTLTLQLS
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEHH
CLIGLMPLTLHWYSYGSINGFLANLFSIPLVSFLIVPLALMTMITSPLHWSWILMKPLAW
HHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LVALLLQGLTYVEQIAGINITWSITSVTMMLAMTAGLFLRVLLPVKPFKHLAILWIILPL
HHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
FPPRTAIYPGEALINILDVGQGLAVAIQTQHHVLLYDTGDSYFQGSDLGQMAIIPFFRSI
CCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHC
GIKTIDKIVISHPDKDHKGGLNSLEKEMQVNQLIVNDPYFYKRGSNCHSYPQWQWDGVSF
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCEEEECCCEEEECCCCCCCCCCEEECCEEE
RFLPIKESFTKKNNNSCILQVSNSAGRVLLTGDIEKAAEEYLVRNYGSQLASEILVVPHH
EEEECCHHHCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCEEEECCC
GSKTSSSYRFLLEVNPLYAIASLGFDNRFKFPHSKTLQSMKTLDITFFRTDECGMAAIKL
CCCCCCCEEEEEEECCHHEEECCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCEEEEEC
PASGQVHRPSCMQAN
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIYCFLIGVLYAYTYNIYLTIAIPLLFYITPRYPIVLFFIAGCGFALIHQWIVSPKGMP
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCC
DTQVITQAQLEGTIASIPMQRPNKTQFHFAIEKINNNPAQGLIQLNWYNKPPVLRAGQRW
CHHHHHHHHHCCHHEECCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEE
QLSVKLKKPRNFRNPGGFNYVRYLAARHIHWTGYIRYGNNKLISNQPPSFSWLTLREKIG
EEEEEEECCCCCCCCCCHHHHHHHHHHCEEEEEEEEECCCEEECCCCCCCEEEHHHHHHH
DALTKLAPNTETAGIIEALTLNVTHHISSEHWNLFRRTGTVHLFGISGEHIALVSCIFFI
HHHHHCCCCCCCCHHHHHEEEEHHECCCCHHHHHHEECCEEEEEECCCCHHHHHHHHHHH
VIRWIWSMSYRCCLFLPAHTIASIGGLLAALPYAFLAGFEPPVQRALIGCVLYTIYAIGK
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
QRFTPWQIWRYALFLVLCIEPHAVFLQGFYFSFLAVACLLLTHQRWPLKNYKKTLTLQLS
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEHH
CLIGLMPLTLHWYSYGSINGFLANLFSIPLVSFLIVPLALMTMITSPLHWSWILMKPLAW
HHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LVALLLQGLTYVEQIAGINITWSITSVTMMLAMTAGLFLRVLLPVKPFKHLAILWIILPL
HHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
FPPRTAIYPGEALINILDVGQGLAVAIQTQHHVLLYDTGDSYFQGSDLGQMAIIPFFRSI
CCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHC
GIKTIDKIVISHPDKDHKGGLNSLEKEMQVNQLIVNDPYFYKRGSNCHSYPQWQWDGVSF
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCEEEECCCEEEECCCCCCCCCCEEECCEEE
RFLPIKESFTKKNNNSCILQVSNSAGRVLLTGDIEKAAEEYLVRNYGSQLASEILVVPHH
EEEECCHHHCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCEEEECCC
GSKTSSSYRFLLEVNPLYAIASLGFDNRFKFPHSKTLQSMKTLDITFFRTDECGMAAIKL
CCCCCCCEEEEEEECCHHEEECCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCEEEEEC
PASGQVHRPSCMQAN
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 8094880 [H]