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The map label for this gene is dsbD [H]

Identifier: 148360662

GI number: 148360662

Start: 847201

End: 848961

Strand: Reverse

Name: dsbD [H]

Synonym: LPC_2608

Alternate gene names: 148360662

Gene position: 848961-847201 (Counterclockwise)

Preceding gene: 148360657

Following gene: 148360663

Centisome position: 23.74

GC content: 41.68

Gene sequence:

>1761_bases
ATGAAAAAATGGCTCTTATTTTCCCTATTATTTTTAACTTCCCTTTGTGTTCATGCTGAGCCCTTGCCAGCTTCTGAAGT
ATTCAAGGTTAGTGTAAAAAAAATAGACCCCAATACCTTTGCCATACAATGGAATATCTTGCCCAAGTATTTTTTATATA
GCGACCGTATTCAATTAAATTCCGATAATGATGACATTGCACAGCTTGGAACTCTTCGCTTCCCCACCCCCTTAACCAAA
ACGGATAAACAAGGGCGAACCTTTAAAGTTTATCGCAATCAGCTTAACCTTCCAGTGGGAGTCCTGGGCATTACCCCAGG
AGAAACAATAGTCAATTTGCGTTTTCAAGGATGTGCCGACGATGGTTTTTGTTATCCCCCCGAAGTAAAACAAATCAAAC
TGGCAATTGACGATAAACTGGCTCTTTCTCAAGTTGATTTGGAAACATTCCATGCACCTGAAGCAACACCTCTTGAAAAA
CCGGAACAAGACATCGCTGATATTTTTGCAAATCATAATTGGATAATGATTCTGCTTATATTTTACGGATTTGGCCTGCT
CCTGTCCTTCACGCCTTGTATACTGCCTATGGTCCCTGTCCTTTCAGGTATTATTGTTGGCCATGGGAAAACGGCAACAA
CGAAAAAAGCGTTTTTCCTGTCATTAAGCTACGTTCTTAGCATGTCTGTCACTTATGCTGTTGTGGGTGCTGTCGTTGCC
TTGCTTGGAGCCAATTTACAAATCAGTATGCAATCACCTTGGGCTATCAGTCTATTCAGTCTGATATTCGTTTTGCTGGC
CTTGTCCATGTTTGGCTTTTATGAATTCAAACTGCCAGATGCATGGCAAAGCAAAATTGTAGGTTCAAGTCGTGAACAAC
GTGGTGGACACTATCTTGGGGCAGCCATCATGGGATGTTTGTCCACACTTATTCTGTCACCATGTGTTACAGCACCATTA
ATTGGAGTATTAACCTACATAGCACAAACCGGAAACGTATTACTCGGCAGTGTCACTCTATTTACATTAAGCCTCGGCAT
GGGTACTCCATTACTGCTGATAGGAACTTCTGCTGGTAAATGGCTACCCGAAACAGGAAGCTGGATGAATGCTGTTAAAG
CTTTCTTTGGCATATTACTTCTTGCTGTTGCCATCTATCTGATGGCACGCATTTTACCAGCAGGTTTGGTCATGGGGCTA
TGGGCTTGTCTCCTGATCTTTTCCGGCATTTACTCTGGTGCCTTAACCAAATCGAATACCAACCAGGAAAAGCTCTGCCA
AGGCATTGGTATCATTTTATTAACCTATGGATTGCTGATTCTCATTGGAGCTAGCATGGGCTCTTCCAACCCTTTGCAGC
CTTTAGCCAACTTACAAGCAGCCCCTACTGTAAGCAATGCTTTTGAATCGGCTAAAGCCCAATCTGTTAAAAGTGTTGAA
CTGGCTATAAAACAAGCGTTCGGAAAACCAGTGATGCTTGATTTTTATGCTGACTGGTGTGCATCGTGTAAAGTGATGGA
AAACACCACGTTCAAAGATCCTCGTGTACAAAAAGCTTTGAGCCATTTTATCGTTATCAAAGTGGATGTGACTGCCAATA
ATAAAAATGACAGAGCATTAATGCAGCATTTCCGTGTAGTAGCCCCCCCGACTTTTATCTTTTTTAATGCTGAGGGCGTA
CAACTCAATAATTTGAAAAGAGTTGGTGAATTGAATGCCGATGAATTCATGCAAACAATAAAAAGCATTGATGAGAACTA
A

Upstream 100 bases:

>100_bases
GGACAATAAACAAACTTTCAAGGGTAAAATCAAAAAAAATTTTGGATTTGGGATTACAGAGTCTACAATAATGTTTATTA
GTAACAGTAAAAGATATCGA

Downstream 100 bases:

>100_bases
AGTAACTATGGGCGCTTTTGTATGAAATCAGTCGACACTGGAACGATTAAGCAGTATAATTAGCTCATTTTTTTTACAGA
TAGAAGTTTATGAATCATAA

Product: hypothetical protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLNSDNDDIAQLGTLRFPTPLTK
TDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEK
PEQDIADIFANHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSVTYAVVGAVVA
LLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLGAAIMGCLSTLILSPCVTAPL
IGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGL
WACLLIFSGIYSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFESAKAQSVKSVE
LAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDRALMQHFRVVAPPTFIFFNAEGV
QLNNLKRVGELNADEFMQTIKSIDEN

Sequences:

>Translated_586_residues
MKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLNSDNDDIAQLGTLRFPTPLTK
TDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEK
PEQDIADIFANHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSVTYAVVGAVVA
LLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLGAAIMGCLSTLILSPCVTAPL
IGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGL
WACLLIFSGIYSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFESAKAQSVKSVE
LAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDRALMQHFRVVAPPTFIFFNAEGV
QLNNLKRVGELNADEFMQTIKSIDEN
>Mature_586_residues
MKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLNSDNDDIAQLGTLRFPTPLTK
TDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCADDGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEK
PEQDIADIFANHNWIMILLIFYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSVTYAVVGAVVA
LLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLGAAIMGCLSTLILSPCVTAPL
IGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGKWLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGL
WACLLIFSGIYSGALTKSNTNQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFESAKAQSVKSVE
LAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDRALMQHFRVVAPPTFIFFNAEGV
QLNNLKRVGELNADEFMQTIKSIDEN

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=563, Percent_Identity=34.1030195381883, Blast_Score=338, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 64060; Mature: 64060

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLN
CCHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCEEEEEEECCCCCCEEECEEEEC
SDNDDIAQLGTLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCAD
CCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEECCCCEEEEEEEECCCC
DGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEKPEQDIADIFANHNWIMILLI
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHH
FYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSVTYAVVGAVVA
HHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLG
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCHHCCCCHHH
AAIMGCLSTLILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEECCCCC
WLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGLWACLLIFSGIYSGALTKSNT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFESAKAQSVKSVE
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
LAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDRAL
HHHHHHCCCCEEEHHHHHHHHCCEEECCCCCCCHHHHHHHCCEEEEEEEEEECCCCHHHH
MQHFRVVAPPTFIFFNAEGVQLNNLKRVGELNADEFMQTIKSIDEN
HHHHHHCCCCEEEEEECCCCEECCHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKWLLFSLLFLTSLCVHAEPLPASEVFKVSVKKIDPNTFAIQWNILPKYFLYSDRIQLN
CCHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCEEEEEEECCCCCCEEECEEEEC
SDNDDIAQLGTLRFPTPLTKTDKQGRTFKVYRNQLNLPVGVLGITPGETIVNLRFQGCAD
CCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEECCCCEEEEEEEECCCC
DGFCYPPEVKQIKLAIDDKLALSQVDLETFHAPEATPLEKPEQDIADIFANHNWIMILLI
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHH
FYGFGLLLSFTPCILPMVPVLSGIIVGHGKTATTKKAFFLSLSYVLSMSVTYAVVGAVVA
HHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGANLQISMQSPWAISLFSLIFVLLALSMFGFYEFKLPDAWQSKIVGSSREQRGGHYLG
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCHHCCCCHHH
AAIMGCLSTLILSPCVTAPLIGVLTYIAQTGNVLLGSVTLFTLSLGMGTPLLLIGTSAGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEECCCCC
WLPETGSWMNAVKAFFGILLLAVAIYLMARILPAGLVMGLWACLLIFSGIYSGALTKSNT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NQEKLCQGIGIILLTYGLLILIGASMGSSNPLQPLANLQAAPTVSNAFESAKAQSVKSVE
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
LAIKQAFGKPVMLDFYADWCASCKVMENTTFKDPRVQKALSHFIVIKVDVTANNKNDRAL
HHHHHHCCCCEEEHHHHHHHHCCEEECCCCCCCHHHHHHHCCEEEEEEEEEECCCCHHHH
MQHFRVVAPPTFIFFNAEGVQLNNLKRVGELNADEFMQTIKSIDEN
HHHHHHCCCCEEEEEECCCCEECCHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA