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The map label for this gene is macA [H]

Identifier: 148360503

GI number: 148360503

Start: 1032347

End: 1033363

Strand: Reverse

Name: macA [H]

Synonym: LPC_2444

Alternate gene names: 148360503

Gene position: 1033363-1032347 (Counterclockwise)

Preceding gene: 148360500

Following gene: 148360504

Centisome position: 28.89

GC content: 40.02

Gene sequence:

>1017_bases
ATGAAAAAATATTTAACTTTTATAGTGTCAGGCTTAGCCTTACTTGCAATAATATGGTTCATTCGCCACTTATGGATAAT
TGGAACTGTCAAGGTTGTGCGTCCTGTTTATGGAACTGCAGTTCAAGCTGTTTATGCCACAGGGACAGTCGAACCAACCG
TCATGATGCCAATTGCCTCACAAAATACAGCCCGCCTTGTCAAGTTGAATGCAGATGAGGGTTCGGAGGTAGTAAAGGGA
CAGATATTAGCCAGCCTGGAAGATGAACACCTGCAACATAACTTAAAAGAGCTGAAAGAACATGAAACATTAGCAAAAAT
AAGATACGAGCGGAATGCTCAATTAGTTAAAAAAGGAGTCATCTCCAAAGATGAGTATGATCGCACCTTGTCCGAATGGC
AAGCAGCCAGTGCCGCCGTACGCAGAATAGAAGCTCAAATCAGTTATTTACAACTGATAGCCCCTGCAGATGGCCGTATC
ATTAAACGTGACGGTGAAGTTGGACAACTAATCCCGGCAAATCAACCTGTATTTTGGCTTTCTTGCTGTGCTCCCCTAAG
AGTTTCCGCTGAAGTCGATGAAGAAGACATTGTATTGGTCAGAGTCGGGCAAAAAGTGTTGATCAGATCAGATGCTTTTC
CAAATCAAATCTTTTATGGCCGTGTCAAAAGCATCACCCCTAAAGGCGATCCAATAGCCAGAAGTTACAGAGTTCGCATT
AATTTTTCAGAAAATAATCCTTTATTGATTGGTATGACAGCTGAAACCAATATTATTGTTCATGAAAAGAAAAATGCCTT
ATTGCTGCCTGTAAGTAGTATTTCTGAAAACAAAGTTTGGATTGTAGAGGATGATGGGAAGCTCTCTCAAAATACAGTGA
CTATTGGCGCAAGAGGATTAAAACAAGCCGAGATTTTAAAAGGTGTCAATATTAACGACCTGGTTGTCTTACAACCTGAT
AATAAGTTAAAAAATGGGCAAAAAGTGCGTTTCATTCTTGTAAAACAGGAAGAATAA

Upstream 100 bases:

>100_bases
AAAACACTTTGTAACAAAGAGCATAGGGGCTTAAGCAAATTCTAATGAAACAAGCTTTTCAATCATCACTTTAAAAGCCC
ATATCAAAGGCTAGTCGTTT

Downstream 100 bases:

>100_bases
TGAAGCTATTTTTAAAGATTGCTTTAAAACATTTGCTTGCACGCAAACGACAAAGCCTGGTTTCTTTGATGGGAATTGTA
TTGGGAGTAGCCTTCTTTTT

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKKYLTFIVSGLALLAIIWFIRHLWIIGTVKVVRPVYGTAVQAVYATGTVEPTVMMPIASQNTARLVKLNADEGSEVVKG
QILASLEDEHLQHNLKELKEHETLAKIRYERNAQLVKKGVISKDEYDRTLSEWQAASAAVRRIEAQISYLQLIAPADGRI
IKRDGEVGQLIPANQPVFWLSCCAPLRVSAEVDEEDIVLVRVGQKVLIRSDAFPNQIFYGRVKSITPKGDPIARSYRVRI
NFSENNPLLIGMTAETNIIVHEKKNALLLPVSSISENKVWIVEDDGKLSQNTVTIGARGLKQAEILKGVNINDLVVLQPD
NKLKNGQKVRFILVKQEE

Sequences:

>Translated_338_residues
MKKYLTFIVSGLALLAIIWFIRHLWIIGTVKVVRPVYGTAVQAVYATGTVEPTVMMPIASQNTARLVKLNADEGSEVVKG
QILASLEDEHLQHNLKELKEHETLAKIRYERNAQLVKKGVISKDEYDRTLSEWQAASAAVRRIEAQISYLQLIAPADGRI
IKRDGEVGQLIPANQPVFWLSCCAPLRVSAEVDEEDIVLVRVGQKVLIRSDAFPNQIFYGRVKSITPKGDPIARSYRVRI
NFSENNPLLIGMTAETNIIVHEKKNALLLPVSSISENKVWIVEDDGKLSQNTVTIGARGLKQAEILKGVNINDLVVLQPD
NKLKNGQKVRFILVKQEE
>Mature_338_residues
MKKYLTFIVSGLALLAIIWFIRHLWIIGTVKVVRPVYGTAVQAVYATGTVEPTVMMPIASQNTARLVKLNADEGSEVVKG
QILASLEDEHLQHNLKELKEHETLAKIRYERNAQLVKKGVISKDEYDRTLSEWQAASAAVRRIEAQISYLQLIAPADGRI
IKRDGEVGQLIPANQPVFWLSCCAPLRVSAEVDEEDIVLVRVGQKVLIRSDAFPNQIFYGRVKSITPKGDPIARSYRVRI
NFSENNPLLIGMTAETNIIVHEKKNALLLPVSSISENKVWIVEDDGKLSQNTVTIGARGLKQAEILKGVNINDLVVLQPD
NKLKNGQKVRFILVKQEE

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=357, Percent_Identity=26.3305322128852, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87082036, Length=312, Percent_Identity=22.4358974358974, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37775; Mature: 37775

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYLTFIVSGLALLAIIWFIRHLWIIGTVKVVRPVYGTAVQAVYATGTVEPTVMMPIAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEECC
QNTARLVKLNADEGSEVVKGQILASLEDEHLQHNLKELKEHETLAKIRYERNAQLVKKGV
CCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
ISKDEYDRTLSEWQAASAAVRRIEAQISYLQLIAPADGRIIKRDGEVGQLIPANQPVFWL
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCCCCCCCCCCEEEE
SCCAPLRVSAEVDEEDIVLVRVGQKVLIRSDAFPNQIFYGRVKSITPKGDPIARSYRVRI
ECCCCEEEECCCCCCCEEEEEECCEEEEECCCCCCCEEECEEEECCCCCCCCCEEEEEEE
NFSENNPLLIGMTAETNIIVHEKKNALLLPVSSISENKVWIVEDDGKLSQNTVTIGARGL
EECCCCCEEEEEECCCEEEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCC
KQAEILKGVNINDLVVLQPDNKLKNGQKVRFILVKQEE
CHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MKKYLTFIVSGLALLAIIWFIRHLWIIGTVKVVRPVYGTAVQAVYATGTVEPTVMMPIAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEECC
QNTARLVKLNADEGSEVVKGQILASLEDEHLQHNLKELKEHETLAKIRYERNAQLVKKGV
CCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
ISKDEYDRTLSEWQAASAAVRRIEAQISYLQLIAPADGRIIKRDGEVGQLIPANQPVFWL
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCCCCCCCCCCEEEE
SCCAPLRVSAEVDEEDIVLVRVGQKVLIRSDAFPNQIFYGRVKSITPKGDPIARSYRVRI
ECCCCEEEECCCCCCCEEEEEECCEEEEECCCCCCCEEECEEEECCCCCCCCCEEEEEEE
NFSENNPLLIGMTAETNIIVHEKKNALLLPVSSISENKVWIVEDDGKLSQNTVTIGARGL
EECCCCCEEEEEECCCEEEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCC
KQAEILKGVNINDLVVLQPDNKLKNGQKVRFILVKQEE
CHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]