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The map label for this gene is dapE [H]

Identifier: 148360467

GI number: 148360467

Start: 1066622

End: 1067755

Strand: Reverse

Name: dapE [H]

Synonym: LPC_2406

Alternate gene names: 148360467

Gene position: 1067755-1066622 (Counterclockwise)

Preceding gene: 148360466

Following gene: 148360472

Centisome position: 29.85

GC content: 40.65

Gene sequence:

>1134_bases
ATGACTGATATTAAGCAAATTCTGACTGACCTCATTCGTTTTCCTTCTATTACACCAGAAGATGCTGGCTGCCAAAAATA
CATGATTCAATTTCTGGAGCAATTGGGATTTACTTGTCAACAACTGAATAATGGGCCTGTATCCAATTTCTTTGCCTGCT
ATGGCAAAATTGGGCCTTTATTGGTGTTCGCAGGCCATACCGATGTAGTTCCTGTTGGTGAAGTATCAAAATGGGATACA
GACCCTTTCTCGCTCGAAGAAAAAAATGGCGTGCTCTATGGTCGTGGGGTTGCTGATATGAAAGGCAGCCTGGCCTGTAT
GTTGCACATGGCCAGAAGATTTATTAAAACTTATCCTTCCTTTCCAGGCAGACTAGGATTTCTGATCACTAGTGGCGAAG
AAGGCGATGAATTTAATTTGGGCACCCCTTATGTGATGCAAAAACTGGAGCAGCAAGGGATTGTTATTGATTATTGCATA
GTAGGTGAACCTTCAAGCAGCTTGAAAGCTGGTGATATCATCAAAATTGGAAGGCGTGGATCATTAAGTGCCAAAATACA
TCTGAGTGGAAAGCAAGGTCATGTTGCCTATCCGCATTTGGCTGACAATCCAATTCATAGAATTAGCCCCGTATTAGCCG
AACTCACTTCAATGCAATGGGATAATGGCAATGCTTATTTTCCTCCTACCTCCATGCAAATAACTTATATTCATTGTGGA
GGGCATGCGGGTAATATTATCCCAGGCGAATTAAATCTGCATTTGAACTTTAGATATTCGACAGAGCAAACAGACGAGTC
GTTAAAAACGAGAGTAATTAATGCCTTTACACACCATAATCTTAACCCCGCTATAGAATGGCGATTAAATGGCGAACCAT
TCTTAACGAATAAAGGCATATTGCTAGAAAGTTGCAAACAAACAGTGCTTGAACATATTGGGACTCTCCCCGAGCTTTCA
ACAAGTGGTGGAACTTCAGATGGGCGTTTTATAGCACCTTATGGGGTTGAGGTTATAGAGCTGGGACTGGTAAATGCAAC
CATTCATCAGGTTAATGAATGCACTTCTCTACAGGATTTGAATACACTTGAAACCATGTATTTTTCAATCTGTGAGAAAT
TATTAATTGATTAA

Upstream 100 bases:

>100_bases
GATGGAAGCCACAGTTTATATTGTGCTGTCATTGTGAAACAAGTGGATGAAAAAACTCGCGCGAAGGTAAGCATTAATGA
TTTACTAAGAGCCAATCAAG

Downstream 100 bases:

>100_bases
TCAAGCCAATTCTGTAATGAGGGTTCGCACCAACAATCCAAATTACAGTAATAGGTTAGTAACCTCATCTTTAAATATCC
TCTGGCGGTCGGATTTGAGT

Product: succinyl-diaminopimelate desuccinylase

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTDIKQILTDLIRFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPLLVFAGHTDVVPVGEVSKWDT
DPFSLEEKNGVLYGRGVADMKGSLACMLHMARRFIKTYPSFPGRLGFLITSGEEGDEFNLGTPYVMQKLEQQGIVIDYCI
VGEPSSSLKAGDIIKIGRRGSLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHNLNPAIEWRLNGEPFLTNKGILLESCKQTVLEHIGTLPELS
TSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDLNTLETMYFSICEKLLID

Sequences:

>Translated_377_residues
MTDIKQILTDLIRFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPLLVFAGHTDVVPVGEVSKWDT
DPFSLEEKNGVLYGRGVADMKGSLACMLHMARRFIKTYPSFPGRLGFLITSGEEGDEFNLGTPYVMQKLEQQGIVIDYCI
VGEPSSSLKAGDIIKIGRRGSLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHNLNPAIEWRLNGEPFLTNKGILLESCKQTVLEHIGTLPELS
TSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDLNTLETMYFSICEKLLID
>Mature_376_residues
TDIKQILTDLIRFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPLLVFAGHTDVVPVGEVSKWDTD
PFSLEEKNGVLYGRGVADMKGSLACMLHMARRFIKTYPSFPGRLGFLITSGEEGDEFNLGTPYVMQKLEQQGIVIDYCIV
GEPSSSLKAGDIIKIGRRGSLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCGG
HAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHNLNPAIEWRLNGEPFLTNKGILLESCKQTVLEHIGTLPELST
SGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDLNTLETMYFSICEKLLID

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788816, Length=372, Percent_Identity=49.1935483870968, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1789236, Length=218, Percent_Identity=26.1467889908257, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790395, Length=269, Percent_Identity=28.6245353159851, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551016, Length=270, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17563146, Length=221, Percent_Identity=25.7918552036199, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 41639; Mature: 41508

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIKQILTDLIRFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPL
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCE
LVFAGHTDVVPVGEVSKWDTDPFSLEEKNGVLYGRGVADMKGSLACMLHMARRFIKTYPS
EEECCCCCCEECCCCCCCCCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
FPGRLGFLITSGEEGDEFNLGTPYVMQKLEQQGIVIDYCIVGEPSSSLKAGDIIKIGRRG
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCC
SLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
CCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCEECCCCEECCCCCEEEEEEEEC
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHNLNPAIEWRLNGEPFLTNKGI
CCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCH
LLESCKQTVLEHIGTLPELSTSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEEHHHHHHHHHHHHCCHHHH
NTLETMYFSICEKLLID
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDIKQILTDLIRFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPL
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCE
LVFAGHTDVVPVGEVSKWDTDPFSLEEKNGVLYGRGVADMKGSLACMLHMARRFIKTYPS
EEECCCCCCEECCCCCCCCCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
FPGRLGFLITSGEEGDEFNLGTPYVMQKLEQQGIVIDYCIVGEPSSSLKAGDIIKIGRRG
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCC
SLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
CCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCEECCCCEECCCCCEEEEEEEEC
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHNLNPAIEWRLNGEPFLTNKGI
CCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCH
LLESCKQTVLEHIGTLPELSTSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEEHHHHHHHHHHHHCCHHHH
NTLETMYFSICEKLLID
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA