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The map label for this gene is rocC [H]

Identifier: 148360378

GI number: 148360378

Start: 1171803

End: 1173266

Strand: Reverse

Name: rocC [H]

Synonym: LPC_2317

Alternate gene names: 148360378

Gene position: 1173266-1171803 (Counterclockwise)

Preceding gene: 148360374

Following gene: 148360380

Centisome position: 32.81

GC content: 40.92

Gene sequence:

>1464_bases
GTGAAGACTAATATTCCAACCCTATCAAAACCCATTAAAGACAGTGGTTACAGACGAGGTTTAAAAGATCGTCATGTCCA
ACTGATTGCACTAGGTGGAATTATCGGCTCAGGATATTTTTTAGGAACCGGTGAAGTAATTAATCTTGTTGGCCCCTCTG
TGTTTATTGCCTACTTACTTGGTGGGTTAATTATTTACCTAACCATGCTATGTATGGGTGAATTAGCAGTCGCCATTCCA
ATTTCCGGCTCTTTTGTTACTTACACTTCTGATTTTATATCCCCAACTGTCGCTTGCGGTGTCGGGTGGTCATATTGGAT
TACCTGGGTCGCCTATATCCCCGCAGAATGTGTTGCGGGAGGGATCATAATGGAATTGTTTACTGGGGTGAGTGGTTACA
TATGGGTGGTATGCTTCGGATTAATTATTACCTATATTAACCTTGCTAAAGTCGATACGTTTGGTGAAATTGAATTCTGG
CTCGCCTTAATTAAAATTATCTCATTACTCGCCTTTGTTTTCCTGGCAATACTAATTTTCTTTGGCCTCATTCATGGATC
AGAACCACCCGGTATAATAGGATTTAAGTACCTGTTAGGCGATGGAGGTCTGTTACCTAATGGGGCAATGTCGTTGTTGA
CAGCCATGGTACTTTTGTTGGTTAATTACCAAGGATCTGAAATCATAGGACTTGCAGCGGGAGAATCTGAAAACCCTGCC
CGAATGATCCCTCACGCCATCCGTAACGTTACTTTCAGAATCCTGTTTCTCTACATCATTCCAGTATTTTGCCTGGTTTT
AATTTTTCCCTGGCAAAAGGCTGGGTTATCCAACTCAGTCTTCGCTGATGCGCTTAATTTCTACGGCCTGAAATGGGCAG
GAGCAGTAACGAGTTTTGTCACTCTGTCTGCAACCTTATCCTGCGCTAATTCCGGATTTTATGGTGCTGTGCGTTCTTTA
AATGCTTTGGCACGTGATGGGATGGCCCCACATGTTTTAGCCAAATTTAATCAAAACTCTGTTCCTCAGAATGCCGTTAT
TGCCACACTGATTGGAGTTTGGATTCTTTTGGGTGTGGGTTACTTTTTTGGTCAAACGAAACTCTATATTGCTTTATTAT
TAGTATCCGGTTTTACCGGAACGCTGGCTTGGCTTTCTTTATGCGTTGCTCAAATCAGCTTTAGAAACCGTTTGTATAAA
GCCGGCTACTCCATTAAAGATCTCCGTTATGTAACACCTTATTCACCTTATACTGGAATTCTTGCTGTTATTTTGATGGT
TGGCTCCTTATTTTTCTTACTGCTAAATAAAGATCCCATCTATAAATTATCATTTATTATTGGTGTGGTGAGCTTCATTA
TACCCGTCATCATCTATAAGGTCTTTGATTTATCCAAGGTTAGGAAAAAAGCTTTGCACGTGAAAAGCAGGGTGAAATTT
CAGGATTTATTTCCGCCACAGTAA

Upstream 100 bases:

>100_bases
ATGAAAAATATTTTTTAATCTGGAGCAGTTTTAAATTTATATGGATAAATATAACATTAGCTCTATTATTTTTTACTAAC
ATAGTGAGAAAAAACAGCCC

Downstream 100 bases:

>100_bases
ATTAAACATTATTTTTGAAGTATTTCTGGGCGTGCCAGAATTCATTTTGCACGCCTCACTCATAAAATCACAGTAATTAC
CTGCATCAATCAAAAATATT

Product: amino acid permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKTNIPTLSKPIKDSGYRRGLKDRHVQLIALGGIIGSGYFLGTGEVINLVGPSVFIAYLLGGLIIYLTMLCMGELAVAIP
ISGSFVTYTSDFISPTVACGVGWSYWITWVAYIPAECVAGGIIMELFTGVSGYIWVVCFGLIITYINLAKVDTFGEIEFW
LALIKIISLLAFVFLAILIFFGLIHGSEPPGIIGFKYLLGDGGLLPNGAMSLLTAMVLLLVNYQGSEIIGLAAGESENPA
RMIPHAIRNVTFRILFLYIIPVFCLVLIFPWQKAGLSNSVFADALNFYGLKWAGAVTSFVTLSATLSCANSGFYGAVRSL
NALARDGMAPHVLAKFNQNSVPQNAVIATLIGVWILLGVGYFFGQTKLYIALLLVSGFTGTLAWLSLCVAQISFRNRLYK
AGYSIKDLRYVTPYSPYTGILAVILMVGSLFFLLLNKDPIYKLSFIIGVVSFIIPVIIYKVFDLSKVRKKALHVKSRVKF
QDLFPPQ

Sequences:

>Translated_487_residues
MKTNIPTLSKPIKDSGYRRGLKDRHVQLIALGGIIGSGYFLGTGEVINLVGPSVFIAYLLGGLIIYLTMLCMGELAVAIP
ISGSFVTYTSDFISPTVACGVGWSYWITWVAYIPAECVAGGIIMELFTGVSGYIWVVCFGLIITYINLAKVDTFGEIEFW
LALIKIISLLAFVFLAILIFFGLIHGSEPPGIIGFKYLLGDGGLLPNGAMSLLTAMVLLLVNYQGSEIIGLAAGESENPA
RMIPHAIRNVTFRILFLYIIPVFCLVLIFPWQKAGLSNSVFADALNFYGLKWAGAVTSFVTLSATLSCANSGFYGAVRSL
NALARDGMAPHVLAKFNQNSVPQNAVIATLIGVWILLGVGYFFGQTKLYIALLLVSGFTGTLAWLSLCVAQISFRNRLYK
AGYSIKDLRYVTPYSPYTGILAVILMVGSLFFLLLNKDPIYKLSFIIGVVSFIIPVIIYKVFDLSKVRKKALHVKSRVKF
QDLFPPQ
>Mature_487_residues
MKTNIPTLSKPIKDSGYRRGLKDRHVQLIALGGIIGSGYFLGTGEVINLVGPSVFIAYLLGGLIIYLTMLCMGELAVAIP
ISGSFVTYTSDFISPTVACGVGWSYWITWVAYIPAECVAGGIIMELFTGVSGYIWVVCFGLIITYINLAKVDTFGEIEFW
LALIKIISLLAFVFLAILIFFGLIHGSEPPGIIGFKYLLGDGGLLPNGAMSLLTAMVLLLVNYQGSEIIGLAAGESENPA
RMIPHAIRNVTFRILFLYIIPVFCLVLIFPWQKAGLSNSVFADALNFYGLKWAGAVTSFVTLSATLSCANSGFYGAVRSL
NALARDGMAPHVLAKFNQNSVPQNAVIATLIGVWILLGVGYFFGQTKLYIALLLVSGFTGTLAWLSLCVAQISFRNRLYK
AGYSIKDLRYVTPYSPYTGILAVILMVGSLFFLLLNKDPIYKLSFIIGVVSFIIPVIIYKVFDLSKVRKKALHVKSRVKF
QDLFPPQ

Specific function: Putative transport protein involved in arginine degradative pathway. Probably transports arginine or ornithine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=374, Percent_Identity=25.4010695187166, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788480, Length=429, Percent_Identity=36.5967365967366, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI87081708, Length=473, Percent_Identity=31.9238900634249, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI48994972, Length=473, Percent_Identity=32.5581395348837, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789017, Length=408, Percent_Identity=33.8235294117647, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786789, Length=473, Percent_Identity=31.5010570824524, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786602, Length=456, Percent_Identity=30.4824561403509, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1790653, Length=368, Percent_Identity=31.7934782608696, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786302, Length=386, Percent_Identity=31.3471502590674, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87081915, Length=415, Percent_Identity=30.8433734939759, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI87081869, Length=317, Percent_Identity=23.6593059936909, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=366, Percent_Identity=23.7704918032787, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=467, Percent_Identity=30.406852248394, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=435, Percent_Identity=29.6551724137931, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=430, Percent_Identity=31.8604651162791, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=441, Percent_Identity=27.891156462585, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324924, Length=448, Percent_Identity=26.7857142857143, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=440, Percent_Identity=28.1818181818182, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=456, Percent_Identity=30.0438596491228, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=434, Percent_Identity=30.4147465437788, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=438, Percent_Identity=26.7123287671233, Blast_Score=153, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=479, Percent_Identity=27.1398747390397, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=434, Percent_Identity=27.1889400921659, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=430, Percent_Identity=27.4418604651163, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=458, Percent_Identity=24.0174672489083, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=432, Percent_Identity=27.5462962962963, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319542, Length=416, Percent_Identity=25, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=438, Percent_Identity=25.1141552511416, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=447, Percent_Identity=26.1744966442953, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=559, Percent_Identity=24.3291592128801, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53145; Mature: 53145

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNIPTLSKPIKDSGYRRGLKDRHVQLIALGGIIGSGYFLGTGEVINLVGPSVFIAYLL
CCCCCCCCCCCCCCCHHHCCCCCCCEEEEEECCCHHCCEEECCCHHHHHHHHHHHHHHHH
GGLIIYLTMLCMGELAVAIPISGSFVTYTSDFISPTVACGVGWSYWITWVAYIPAECVAG
HHHHHHHHHHHHHHHEEEEECCCCEEEEEHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHH
GIIMELFTGVSGYIWVVCFGLIITYINLAKVDTFGEIEFWLALIKIISLLAFVFLAILIF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FGLIHGSEPPGIIGFKYLLGDGGLLPNGAMSLLTAMVLLLVNYQGSEIIGLAAGESENPA
HHHHCCCCCCCCEEEHEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCH
RMIPHAIRNVTFRILFLYIIPVFCLVLIFPWQKAGLSNSVFADALNFYGLKWAGAVTSFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCHHHHHHHHHH
TLSATLSCANSGFYGAVRSLNALARDGMAPHVLAKFNQNSVPQNAVIATLIGVWILLGVG
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
YFFGQTKLYIALLLVSGFTGTLAWLSLCVAQISFRNRLYKAGYSIKDLRYVTPYSPYTGI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHH
LAVILMVGSLFFLLLNKDPIYKLSFIIGVVSFIIPVIIYKVFDLSKVRKKALHVKSRVKF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QDLFPPQ
CCCCCCC
>Mature Secondary Structure
MKTNIPTLSKPIKDSGYRRGLKDRHVQLIALGGIIGSGYFLGTGEVINLVGPSVFIAYLL
CCCCCCCCCCCCCCCHHHCCCCCCCEEEEEECCCHHCCEEECCCHHHHHHHHHHHHHHHH
GGLIIYLTMLCMGELAVAIPISGSFVTYTSDFISPTVACGVGWSYWITWVAYIPAECVAG
HHHHHHHHHHHHHHHEEEEECCCCEEEEEHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHH
GIIMELFTGVSGYIWVVCFGLIITYINLAKVDTFGEIEFWLALIKIISLLAFVFLAILIF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FGLIHGSEPPGIIGFKYLLGDGGLLPNGAMSLLTAMVLLLVNYQGSEIIGLAAGESENPA
HHHHCCCCCCCCEEEHEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCH
RMIPHAIRNVTFRILFLYIIPVFCLVLIFPWQKAGLSNSVFADALNFYGLKWAGAVTSFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCHHHHHHHHHH
TLSATLSCANSGFYGAVRSLNALARDGMAPHVLAKFNQNSVPQNAVIATLIGVWILLGVG
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
YFFGQTKLYIALLLVSGFTGTLAWLSLCVAQISFRNRLYKAGYSIKDLRYVTPYSPYTGI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHH
LAVILMVGSLFFLLLNKDPIYKLSFIIGVVSFIIPVIIYKVFDLSKVRKKALHVKSRVKF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QDLFPPQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]