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The map label for this gene is hcr [H]

Identifier: 148360290

GI number: 148360290

Start: 1260296

End: 1262179

Strand: Reverse

Name: hcr [H]

Synonym: LPC_2227

Alternate gene names: 148360290

Gene position: 1262179-1260296 (Counterclockwise)

Preceding gene: 148360289

Following gene: 148360291

Centisome position: 35.29

GC content: 45.44

Gene sequence:

>1884_bases
ATGCTGTTTCAATACATTAAAAAGTTTTTCCTATTTCTATGGGTTCAAGCAGTCTCCATTTCTTTCCTGTTGGCGATGGC
TTCTGTTTCCTTTGCTCAACTCACAGCACAAGACCATGCTGCCCATCATCAAGGAGAAAAAGAAGGCGAGGGAATGAGTG
GTATGATGAAAAATATAGGGACTCCCTCTAAGGAACTTTACCCCTCTTTAATGAGTTTACCCACATTATCCCCCGAAAAA
CGCCTGGAAATTCAACAAAGGGCACATCAACGCATCACATCCGGCATGGCGCTCATGAAAGGTGGACTTAACGAGCTTTT
GTTGGCATCCAGCAATAACAATTACGCTAAAATGCAGGAAGCTTTAGAGAAATTACGGGAAGGGATTACGCAATATGAGA
GCGCACTGGCCGCACTTCGCGCACTGTCTGAAGGAAAAAATCCAAGCGACATCGCCTTGCAGTGGTTTAAACGAGAAATG
AATCTTCTTCCAAGTAGTCCGCAAGCCGAGAGTGTCTTAGGTGGGCCTTTTTTTCATTTAACGATTATCGCTCTATTTGG
TCTGTTTTTTTTGGTCATGATTTGGATGTATTTTTTCAAAATGAGAAGAGCTGCTGCTCTGCTCGATCGCTTAACCAAAC
AAAATGCGGCTGTATCTTCGCAGACACCACCCCAATTCTCAAAAGCACCTGAACCAACCCCTTCCTTAACATCAGCAGAG
CCCATTAAATCCTCTCAAGTTTCTAAAGTGCCATCAGAAACTGCCCCAACTATGCCTCCTACCTGCCCCGCTCATAAATG
TCCAGTCCCGCAATTTCCGGTCATGAGATCACTCACCGAACCGGAAGAGAAATGGGAAGGACAACTTCGTGTTTGCCGTA
TCTTTCAAGAAGCACCAGGAATCAAAACATATCATTTGGCATCAACCCATGAGGTGGCTCTGCCATTTACCTATTATCCT
GGCCAGTTCATAACGCTTACCGCCTTAATTAATGGTAAAACGGTCAGGCGCAGTTACACCATGGCCTCTACCCCAACCCA
ATTGCATTATTGTGCCATTACCGTCAAGCGAGAAGAGCAAGGCGTGTTTTCTCGTTATTTGCATGACGAAATTAAGGAAG
GGGATTTACTGGAGGTGATGGGGCCTAATGGTAAATTTACTTTTACTGGCGAAGAGGCAAAGAGCATTGTACTGATTTGT
GGAGGGGTAGGTATTACCCCGATGATGAGTATCATCCGCTACCTCACCGATATTGGATGGCACAATGACATTTATTTGCT
GTACTGTTGCCGCACGACCAGTGAGTTTCTCTTTCGCGAAGAATTAGAGCAACTTCAAGAAAGATACCTCAATCTCCATG
TGTACGCATCGATGCTGCGTTCAGAAGGAACCATTTGGATGGGGTTACAAGGCCTATTTACCAAGAACATCATCAGCCAT
CTTGTCCCTGATATTGCCTCTCATCGTATCCACGTTTGCGGTCCTCCTGCGATGATGGAAGCAATCCTTGGTATCTTAAA
AGAGCTTAAGGTGCCCGCTGATTTGATTCTAACGGAAGCGTTTGGACCGGAAAAGAAACCAGAAATAGCCCAGGAAGAAT
TAGAGGCCATCAAAGCCGATACCCGCGCGATGGTTTCGTTTCGGAAATCTGAAAAAATGGTTCCGATTCTGCCAGACCGC
ACCCTTCTGGAAATCGCTGAAGCCAACGGGGTTACTATTGATAACGCGTGTCGAACCGGGCAATGTGGGTTATGTAAAGT
AAAATTGCTATCAGGAGAGGTGACCATGGCTTGTGAAGATGCGCTTTCCAAGGAAGACAAACAACAGGGACTTATCTTAG
CCTGTCAGGCCAAAGCGACCAAAAATATTGAGGTGGATGCTTAA

Upstream 100 bases:

>100_bases
TAGTGAATAAACTCATATGAGGCGGGAAAACACTCGTGCAGACTGCTCCACTTTAACCATTTTTTGAATCGTCATGTTAA
GTGGGCTTTGGAGGGAAAGG

Downstream 100 bases:

>100_bases
TGAATGCGCAAGGACGTATGATGGTTTTGGGGTTAGTACTTCTAATGCTTATCACATGGCTAGGCTTTGCAGTCCATACG
TCTTATCGTTTTGCCGGGAG

Product: FAD-binding oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKEGEGMSGMMKNIGTPSKELYPSLMSLPTLSPEK
RLEIQQRAHQRITSGMALMKGGLNELLLASSNNNYAKMQEALEKLREGITQYESALAALRALSEGKNPSDIALQWFKREM
NLLPSSPQAESVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDRLTKQNAAVSSQTPPQFSKAPEPTPSLTSAE
PIKSSQVSKVPSETAPTMPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLRVCRIFQEAPGIKTYHLASTHEVALPFTYYP
GQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDEIKEGDLLEVMGPNGKFTFTGEEAKSIVLIC
GGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYLNLHVYASMLRSEGTIWMGLQGLFTKNIISH
LVPDIASHRIHVCGPPAMMEAILGILKELKVPADLILTEAFGPEKKPEIAQEELEAIKADTRAMVSFRKSEKMVPILPDR
TLLEIAEANGVTIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQGLILACQAKATKNIEVDA

Sequences:

>Translated_627_residues
MLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKEGEGMSGMMKNIGTPSKELYPSLMSLPTLSPEK
RLEIQQRAHQRITSGMALMKGGLNELLLASSNNNYAKMQEALEKLREGITQYESALAALRALSEGKNPSDIALQWFKREM
NLLPSSPQAESVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDRLTKQNAAVSSQTPPQFSKAPEPTPSLTSAE
PIKSSQVSKVPSETAPTMPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLRVCRIFQEAPGIKTYHLASTHEVALPFTYYP
GQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDEIKEGDLLEVMGPNGKFTFTGEEAKSIVLIC
GGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYLNLHVYASMLRSEGTIWMGLQGLFTKNIISH
LVPDIASHRIHVCGPPAMMEAILGILKELKVPADLILTEAFGPEKKPEIAQEELEAIKADTRAMVSFRKSEKMVPILPDR
TLLEIAEANGVTIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQGLILACQAKATKNIEVDA
>Mature_627_residues
MLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKEGEGMSGMMKNIGTPSKELYPSLMSLPTLSPEK
RLEIQQRAHQRITSGMALMKGGLNELLLASSNNNYAKMQEALEKLREGITQYESALAALRALSEGKNPSDIALQWFKREM
NLLPSSPQAESVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDRLTKQNAAVSSQTPPQFSKAPEPTPSLTSAE
PIKSSQVSKVPSETAPTMPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLRVCRIFQEAPGIKTYHLASTHEVALPFTYYP
GQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDEIKEGDLLEVMGPNGKFTFTGEEAKSIVLIC
GGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYLNLHVYASMLRSEGTIWMGLQGLFTKNIISH
LVPDIASHRIHVCGPPAMMEAILGILKELKVPADLILTEAFGPEKKPEIAQEELEAIKADTRAMVSFRKSEKMVPILPDR
TLLEIAEANGVTIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQGLILACQAKATKNIEVDA

Specific function: NADH oxidoreductase acting in concert with HCP [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=254, Percent_Identity=28.740157480315, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI284448553, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI6552328, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI193794826, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI4503327, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI284448551, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI47778923, Length=240, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1787098, Length=346, Percent_Identity=30.0578034682081, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1787658, Length=350, Percent_Identity=28.2857142857143, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788104, Length=335, Percent_Identity=27.1641791044776, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788903, Length=252, Percent_Identity=26.1904761904762, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17563928, Length=271, Percent_Identity=26.5682656826568, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563926, Length=222, Percent_Identity=28.3783783783784, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323552, Length=194, Percent_Identity=28.8659793814433, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323510, Length=191, Percent_Identity=26.7015706806283, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322146, Length=194, Percent_Identity=29.3814432989691, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322699, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321673, Length=229, Percent_Identity=26.6375545851528, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 69895; Mature: 69895

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKEGEGMSGMMKNIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
TPSKELYPSLMSLPTLSPEKRLEIQQRAHQRITSGMALMKGGLNELLLASSNNNYAKMQE
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHH
ALEKLREGITQYESALAALRALSEGKNPSDIALQWFKREMNLLPSSPQAESVLGGPFFHL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHH
TIIALFGLFFLVMIWMYFFKMRRAAALLDRLTKQNAAVSSQTPPQFSKAPEPTPSLTSAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
PIKSSQVSKVPSETAPTMPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLRVCRIFQEAPG
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHCCHHHHHHHHHHCCC
IKTYHLASTHEVALPFTYYPGQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQ
CEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEEEEECCCCCEEEEEEEEEECHHH
GVFSRYLHDEIKEGDLLEVMGPNGKFTFTGEEAKSIVLICGGVGITPMMSIIRYLTDIGW
HHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
HNDIYLLYCCRTTSEFLFREELEQLQERYLNLHVYASMLRSEGTIWMGLQGLFTKNIISH
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
LVPDIASHRIHVCGPPAMMEAILGILKELKVPADLILTEAFGPEKKPEIAQEELEAIKAD
HHHHHHHCEEEEECCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCHHHHHHHHHHHHH
TRAMVSFRKSEKMVPILPDRTLLEIAEANGVTIDNACRTGQCGLCKVKLLSGEVTMACED
HHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCCEEEEEEECCCCHHHHHH
ALSKEDKQQGLILACQAKATKNIEVDA
HHCCCHHHCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKEGEGMSGMMKNIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
TPSKELYPSLMSLPTLSPEKRLEIQQRAHQRITSGMALMKGGLNELLLASSNNNYAKMQE
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHH
ALEKLREGITQYESALAALRALSEGKNPSDIALQWFKREMNLLPSSPQAESVLGGPFFHL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHH
TIIALFGLFFLVMIWMYFFKMRRAAALLDRLTKQNAAVSSQTPPQFSKAPEPTPSLTSAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
PIKSSQVSKVPSETAPTMPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLRVCRIFQEAPG
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHCCHHHHHHHHHHCCC
IKTYHLASTHEVALPFTYYPGQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQ
CEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEEEEECCCCCEEEEEEEEEECHHH
GVFSRYLHDEIKEGDLLEVMGPNGKFTFTGEEAKSIVLICGGVGITPMMSIIRYLTDIGW
HHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
HNDIYLLYCCRTTSEFLFREELEQLQERYLNLHVYASMLRSEGTIWMGLQGLFTKNIISH
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
LVPDIASHRIHVCGPPAMMEAILGILKELKVPADLILTEAFGPEKKPEIAQEELEAIKAD
HHHHHHHCEEEEECCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCHHHHHHHHHHHHH
TRAMVSFRKSEKMVPILPDRTLLEIAEANGVTIDNACRTGQCGLCKVKLLSGEVTMACED
HHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCCEEEEEEECCCCHHHHHH
ALSKEDKQQGLILACQAKATKNIEVDA
HHCCCHHHCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10651802 [H]