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The map label for this gene is ldh [H]

Identifier: 148359820

GI number: 148359820

Start: 2695155

End: 2696228

Strand: Direct

Name: ldh [H]

Synonym: LPC_1745

Alternate gene names: 148359820

Gene position: 2695155-2696228 (Clockwise)

Preceding gene: 148359815

Following gene: 148359821

Centisome position: 75.36

GC content: 41.43

Gene sequence:

>1074_bases
ATGATGTCTGTTGACAATATTAAAAATGATAACCAGGTTTTGGCTGAAGAAGATTTCCTCGAATACGCATTGTCTCATGG
ATTTGGTGATTTACATTTTAAGGTGGATCCGCAAACGGGTATGAAGGCTATGATTGCAATTCATAGTACCAAGTTGGGGC
CTGCTTTGGGTGGTTGTCGATTTATTGAGTACCCTAATACTGCTGCTGCTTTGAAGGATGCTATGCGCCTTGCCAGAGGC
ATGAGCTTTAAGGCTGCTTCAGTCAATTTACCTTTGGGCGGTGGAAAATCGGTTATTATTAAGCCTAAGGGTTTCTTTAA
TCGATCGGAGTACATGCATCGGTTTGGTGAATTCGTTAATGAATTGAATGGCAGGTACATCACTGCTTTGGATAGCGGTA
CTGAATTAAGTGACATGGATATTATTGCTGAGCATACTGACTATGTTGCTAGTTTATCCAGATACAATGGAGATCCTTCA
CCTTCTACTGCTAAGGGTGTATTAAGAGGAATTCAGGCTGCCGTTGCCTTTAAATTAGGTAAAGATTCTCTCAAAGGTTT
GCATATTGCTATTCAGGGTCTTGGCCACGTCGGTTATGCTCTGGCAAAACAATTACACGAATTGGGCGCGACATTAACTG
TTGCTGATATTTCACCTGCTGCTGTGAACATGGCGGTTCAAGAGTTGGGAGCGAAAGCGGTCGGCACTGACATTATCCAT
AAAGTACCGTGTGATGTATTTGCTCCTTGTGCTTTAGGTGCGATTATCAATGATCTTACTATTCCCCAGTTACAAACCAG
TATTATCGCTGGCGCTGCCAATAATCAGCTGGCACACACTTACCATGGCAAGATTTTACACGAAAAAGGCATTTTGTTTG
CTGTGGATTATGTGATTAATGCAGGTGGTTTGATATTCGCAGCCTCTAAATACTTACAAACGCCTGAAGACAAGGTAAGT
GAGCAAATTGATAGTATCTATACCTCTCTGACTGAAATTTTTACTCGTTCTGCTAAGGATAATTTACCTACTAGCGAGAT
TGCTGATACTTTGGCTAAGGAAAAATTGGCTTAA

Upstream 100 bases:

>100_bases
CAAGATGCGCCAAATACGGCCGTTTGCTAAGAATTACATTGATTTAATTGACGAATAGATCTATAACTTCTCCCAAAATT
ATTGCAAGAGGAGCTTAAAA

Downstream 100 bases:

>100_bases
TTTGGATACCGTTTATGAAACATTTATCCCTTACTCCTGAGTTGTACGAATACCTGCTTGATATTTCCTTGCGTGAACAT
CCTGCTCTTGCGGCATTACG

Product: Glu/Leu/Phe/Val dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MMSVDNIKNDNQVLAEEDFLEYALSHGFGDLHFKVDPQTGMKAMIAIHSTKLGPALGGCRFIEYPNTAAALKDAMRLARG
MSFKAASVNLPLGGGKSVIIKPKGFFNRSEYMHRFGEFVNELNGRYITALDSGTELSDMDIIAEHTDYVASLSRYNGDPS
PSTAKGVLRGIQAAVAFKLGKDSLKGLHIAIQGLGHVGYALAKQLHELGATLTVADISPAAVNMAVQELGAKAVGTDIIH
KVPCDVFAPCALGAIINDLTIPQLQTSIIAGAANNQLAHTYHGKILHEKGILFAVDYVINAGGLIFAASKYLQTPEDKVS
EQIDSIYTSLTEIFTRSAKDNLPTSEIADTLAKEKLA

Sequences:

>Translated_357_residues
MMSVDNIKNDNQVLAEEDFLEYALSHGFGDLHFKVDPQTGMKAMIAIHSTKLGPALGGCRFIEYPNTAAALKDAMRLARG
MSFKAASVNLPLGGGKSVIIKPKGFFNRSEYMHRFGEFVNELNGRYITALDSGTELSDMDIIAEHTDYVASLSRYNGDPS
PSTAKGVLRGIQAAVAFKLGKDSLKGLHIAIQGLGHVGYALAKQLHELGATLTVADISPAAVNMAVQELGAKAVGTDIIH
KVPCDVFAPCALGAIINDLTIPQLQTSIIAGAANNQLAHTYHGKILHEKGILFAVDYVINAGGLIFAASKYLQTPEDKVS
EQIDSIYTSLTEIFTRSAKDNLPTSEIADTLAKEKLA
>Mature_357_residues
MMSVDNIKNDNQVLAEEDFLEYALSHGFGDLHFKVDPQTGMKAMIAIHSTKLGPALGGCRFIEYPNTAAALKDAMRLARG
MSFKAASVNLPLGGGKSVIIKPKGFFNRSEYMHRFGEFVNELNGRYITALDSGTELSDMDIIAEHTDYVASLSRYNGDPS
PSTAKGVLRGIQAAVAFKLGKDSLKGLHIAIQGLGHVGYALAKQLHELGATLTVADISPAAVNMAVQELGAKAVGTDIIH
KVPCDVFAPCALGAIINDLTIPQLQTSIIAGAANNQLAHTYHGKILHEKGILFAVDYVINAGGLIFAASKYLQTPEDKVS
EQIDSIYTSLTEIFTRSAKDNLPTSEIADTLAKEKLA

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 38217; Mature: 38217

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVDNIKNDNQVLAEEDFLEYALSHGFGDLHFKVDPQTGMKAMIAIHSTKLGPALGGCR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCE
FIEYPNTAAALKDAMRLARGMSFKAASVNLPLGGGKSVIIKPKGFFNRSEYMHRFGEFVN
EEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHH
ELNGRYITALDSGTELSDMDIIAEHTDYVASLSRYNGDPSPSTAKGVLRGIQAAVAFKLG
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
KDSLKGLHIAIQGLGHVGYALAKQLHELGATLTVADISPAAVNMAVQELGAKAVGTDIIH
CHHHCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHH
KVPCDVFAPCALGAIINDLTIPQLQTSIIAGAANNQLAHTYHGKILHEKGILFAVDYVIN
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEHHCCEEEECCCCEEEEEHHHC
AGGLIFAASKYLQTPEDKVSEQIDSIYTSLTEIFTRSAKDNLPTSEIADTLAKEKLA
CCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MMSVDNIKNDNQVLAEEDFLEYALSHGFGDLHFKVDPQTGMKAMIAIHSTKLGPALGGCR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCE
FIEYPNTAAALKDAMRLARGMSFKAASVNLPLGGGKSVIIKPKGFFNRSEYMHRFGEFVN
EEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHH
ELNGRYITALDSGTELSDMDIIAEHTDYVASLSRYNGDPSPSTAKGVLRGIQAAVAFKLG
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
KDSLKGLHIAIQGLGHVGYALAKQLHELGATLTVADISPAAVNMAVQELGAKAVGTDIIH
CHHHCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHH
KVPCDVFAPCALGAIINDLTIPQLQTSIIAGAANNQLAHTYHGKILHEKGILFAVDYVIN
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEHHCCEEEECCCCEEEEEHHHC
AGGLIFAASKYLQTPEDKVSEQIDSIYTSLTEIFTRSAKDNLPTSEIADTLAKEKLA
CCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]