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The map label for this gene is gad [H]

Identifier: 148359556

GI number: 148359556

Start: 2339420

End: 2340733

Strand: Reverse

Name: gad [H]

Synonym: LPC_1468

Alternate gene names: 148359556

Gene position: 2340733-2339420 (Counterclockwise)

Preceding gene: 148359557

Following gene: 148359552

Centisome position: 65.45

GC content: 41.25

Gene sequence:

>1314_bases
TTGAATAGCATTCCTCATCTCATTTTAGGTGATATTATCACTCCTACGCAAACTGGCCAAAGTCTTCTTATCAAGAAAGG
TTATGTCTTGATCGATGGTGATAGCATTATTGAGGTGGGCGAGCAGGCCCATTTAAATCAAGAAGTATCATGTACAGTGT
CAAATTATCCTGATCATTTAATCCTCCCAGGCCTAATTGATACACATAGTCATCTTTCCCAGTACGCTATTAGTGGATCT
GGCGATTTGCCGTTGATGGATTGGTTAAATGCTTTGGTTTTCCCTGCAGAAGCAGCTTTCGCAAATGACCTGAAAAGATG
TCAACGCCAAGCGGAGCTTTTTATGCATGCTTGTTTGGGTTCTGGCACAACGACTATCAATACTATGGTAACCAGCAATC
GAGAAGCAACAGAAGTAGTTTGCGATGTGGCTGCACGCATGGGTATCAGAGCGTTTATTGGATTGGTATTGATGGATAGA
AATGCTCCTGATAGTTTAGTGGTTGATTGTGATCAAGCATTTAAAGATCTGACCTTTTTAAAAGATAATTACCATGGTAA
AAATAATATACATATTACTGTTTCTCCCCGGTTTGCAGTGACTTGTTCTGCGGCTATGTTGAGGCAAGCAGGTGAGTTCG
CCCGTGCAAACAAGCTGATATTGCATACCCATCTTGATAAGGATGAAGGGTTTGATGAATTGATTCAAAGCTTGTTTAGT
ACAGCTCATGATTATTTTGATGTGTTTGAATCCACACAATGTATTGCTGATAAGACTGTGTTTGCGCATGGCACTTTGTT
ATCACTTCACGAAATGAAACGCATGGGAGACTATGCCAAGCAAGTTGGAATTAGCCATTGTCCCTCCAGTAATTTTTCTT
TTGCTATGGGAATGGCACCGGTTTCTTTTTTTAAAGGCTTGGGGATTGAGGTTGGATTGGGCTCAGACAGTGGTGGAGGG
GACAGTCTTTCTCTTTTTGATGAAATGCGTTCAGCGAGTTTTACTAATAAAGCATTATGGAGGCTTGATAAAAAGACGGC
TCTGCTTGATGCAAAAAGCTGGCTATATCATGCTACTCTTGGAGGAGCGAAATTGCTGGGGTTAGAGAAGCAAATTGGCA
GCATCGAAGCAGGTAAAAAGGCGGATTTGATTATCCTGGATGACAGGAATAACTATCCTCTGGCAGAGCTTTCTTCTTTG
TCACAAGAGTTAGCTCTTGATGAACTTCAGTACCGTCTGGCAAGAGTGGTTGCCAGATCCTGCGAAAACAAGTTAGTTGC
TGTTTATATTGATGGAAAGAAAGTTTATCAGTAA

Upstream 100 bases:

>100_bases
AAGAGCTCTTTTTACTATGATATTTTTTACCCCAAATTTCAGTTAGTCCAAGAGGTTGTCTATACTTTTTGATAGTAAGA
AATAAATCTCAGGATATGAA

Downstream 100 bases:

>100_bases
TCACCAGACCTAATGAGATTCGAGATAAAATCAAGATGATTAATTTCCCAAAATTTTTGAATACGTTTTTAACGTGGAAG
CATCGGGTGACCGATAAACA

Product: guanine aminohydrolase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNSIPHLILGDIITPTQTGQSLLIKKGYVLIDGDSIIEVGEQAHLNQEVSCTVSNYPDHLILPGLIDTHSHLSQYAISGS
GDLPLMDWLNALVFPAEAAFANDLKRCQRQAELFMHACLGSGTTTINTMVTSNREATEVVCDVAARMGIRAFIGLVLMDR
NAPDSLVVDCDQAFKDLTFLKDNYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAPVSFFKGLGIEVGLGSDSGGG
DSLSLFDEMRSASFTNKALWRLDKKTALLDAKSWLYHATLGGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSL
SQELALDELQYRLARVVARSCENKLVAVYIDGKKVYQ

Sequences:

>Translated_437_residues
MNSIPHLILGDIITPTQTGQSLLIKKGYVLIDGDSIIEVGEQAHLNQEVSCTVSNYPDHLILPGLIDTHSHLSQYAISGS
GDLPLMDWLNALVFPAEAAFANDLKRCQRQAELFMHACLGSGTTTINTMVTSNREATEVVCDVAARMGIRAFIGLVLMDR
NAPDSLVVDCDQAFKDLTFLKDNYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAPVSFFKGLGIEVGLGSDSGGG
DSLSLFDEMRSASFTNKALWRLDKKTALLDAKSWLYHATLGGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSL
SQELALDELQYRLARVVARSCENKLVAVYIDGKKVYQ
>Mature_437_residues
MNSIPHLILGDIITPTQTGQSLLIKKGYVLIDGDSIIEVGEQAHLNQEVSCTVSNYPDHLILPGLIDTHSHLSQYAISGS
GDLPLMDWLNALVFPAEAAFANDLKRCQRQAELFMHACLGSGTTTINTMVTSNREATEVVCDVAARMGIRAFIGLVLMDR
NAPDSLVVDCDQAFKDLTFLKDNYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAPVSFFKGLGIEVGLGSDSGGG
DSLSLFDEMRSASFTNKALWRLDKKTALLDAKSWLYHATLGGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSL
SQELALDELQYRLARVVARSCENKLVAVYIDGKKVYQ

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=413, Percent_Identity=29.2978208232446, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789249, Length=430, Percent_Identity=28.1395348837209, Blast_Score=171, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6319963, Length=331, Percent_Identity=30.8157099697885, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24643849, Length=459, Percent_Identity=28.9760348583878, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 47871; Mature: 47871

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIPHLILGDIITPTQTGQSLLIKKGYVLIDGDSIIEVGEQAHLNQEVSCTVSNYPDHL
CCCCCCHHHCCCCCCCCCCCEEEEECCEEEECCCHHHHCCHHHCCCCCEEEEECCCCCCE
ILPGLIDTHSHLSQYAISGSGDLPLMDWLNALVFPAEAAFANDLKRCQRQAELFMHACLG
EECCCHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SGTTTINTMVTSNREATEVVCDVAARMGIRAFIGLVLMDRNAPDSLVVDCDQAFKDLTFL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEHHHHHHHHHHH
KDNYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
HCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHH
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAP
HHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCH
VSFFKGLGIEVGLGSDSGGGDSLSLFDEMRSASFTNKALWRLDKKTALLDAKSWLYHATL
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHEEEEC
GGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSLSQELALDELQYRLARVVARS
CCHHEEEHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CENKLVAVYIDGKKVYQ
CCCCEEEEEECCCCCCC
>Mature Secondary Structure
MNSIPHLILGDIITPTQTGQSLLIKKGYVLIDGDSIIEVGEQAHLNQEVSCTVSNYPDHL
CCCCCCHHHCCCCCCCCCCCEEEEECCEEEECCCHHHHCCHHHCCCCCEEEEECCCCCCE
ILPGLIDTHSHLSQYAISGSGDLPLMDWLNALVFPAEAAFANDLKRCQRQAELFMHACLG
EECCCHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SGTTTINTMVTSNREATEVVCDVAARMGIRAFIGLVLMDRNAPDSLVVDCDQAFKDLTFL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEHHHHHHHHHHH
KDNYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
HCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHH
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAP
HHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCH
VSFFKGLGIEVGLGSDSGGGDSLSLFDEMRSASFTNKALWRLDKKTALLDAKSWLYHATL
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHEEEEC
GGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSLSQELALDELQYRLARVVARS
CCHHEEEHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CENKLVAVYIDGKKVYQ
CCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]