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The map label for this gene is mmgB [H]

Identifier: 148359505

GI number: 148359505

Start: 2277773

End: 2278627

Strand: Reverse

Name: mmgB [H]

Synonym: LPC_1415

Alternate gene names: 148359505

Gene position: 2278627-2277773 (Counterclockwise)

Preceding gene: 148359506

Following gene: 148359504

Centisome position: 63.71

GC content: 37.31

Gene sequence:

>855_bases
ATGAAACAAACAAAACTTACTCTTCTGGGTGCGGGGACAATGGGTTCGGGTATCACTCAGCTTTTTGCACAATACGGATT
TTATGTCACTTTAATCGATAACCTCCAATCTCAATTGGATAAAGCAAAAGACACTATCGCTAAAAATTTACACTATCTGG
CATTAACTCAAAATTTAGAATCGACACATTCTATTGAAACCATCCTGGCATCAATTACCTTTACAACAAAGTTAGATGAG
CTTAAGCAATCGGAATATATTATAGAAAATATCACTGAGAACTGGGAGCGGAAAAAAGCGTTGTATCAGGTATTAAAAAA
AGAATGTAGCGCAACCTGTATTTTGGGGGTAAACACTTCATCCATCCCCATTACTAAAATCGCATCACTTGTTGATCACC
CTCAACGCGTTATAGGTGTTCACTTTATGAACCCGGCACCGATGATGCCTATGGTAGAGGTCATTAAGGGATATCACACT
GACGAATTGACAATAGAAAAAACAAGAACATTACTAGAACAAGTACATAAAAAAATGATCGTTGTTAAGGACTCTGTTGG
TTTTGTGAGTAACCGAGCCATGATGATTTTTATTAACGAAGCCATCTTTATGGTACAGGAAAACATTGCATCAATCGAAG
ACATCGATGTTCTATTTAAACAATGCTTTGGGCATAAGATGGGGCCGCTGCATACGGCTGATTTAATTGGGTTGGATACG
GTTCTCTATTCTTTGGAAACCATCTATTCAGAATTAAACGATCCAAAATATCGACCATGCTGGTTATTAAGAAATATGGT
GGATGCAGGGCTTCTTGGGCAAAAAACAAAAAAGGGATTTTATCAATATGAATAG

Upstream 100 bases:

>100_bases
GGTCACTCCCCTATGTTGGATTTAGGGCAAACAGCCAGAGTTGAGCTTTTACTTATAATTCAATACGAATAGCTGTGATA
AGCTTTGGTGGACAAACGGC

Downstream 100 bases:

>100_bases
GGGGTAGTTTACCATTCGCTATTTCAACCCGGATGGTTAAATTGTAAACAAACACTAGGGAGAGCAATTTTGCCAAATTA
CCAGCCTCAATACGTGAAGC

Product: 3-hydroxyacyl CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKQTKLTLLGAGTMGSGITQLFAQYGFYVTLIDNLQSQLDKAKDTIAKNLHYLALTQNLESTHSIETILASITFTTKLDE
LKQSEYIIENITENWERKKALYQVLKKECSATCILGVNTSSIPITKIASLVDHPQRVIGVHFMNPAPMMPMVEVIKGYHT
DELTIEKTRTLLEQVHKKMIVVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
VLYSLETIYSELNDPKYRPCWLLRNMVDAGLLGQKTKKGFYQYE

Sequences:

>Translated_284_residues
MKQTKLTLLGAGTMGSGITQLFAQYGFYVTLIDNLQSQLDKAKDTIAKNLHYLALTQNLESTHSIETILASITFTTKLDE
LKQSEYIIENITENWERKKALYQVLKKECSATCILGVNTSSIPITKIASLVDHPQRVIGVHFMNPAPMMPMVEVIKGYHT
DELTIEKTRTLLEQVHKKMIVVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
VLYSLETIYSELNDPKYRPCWLLRNMVDAGLLGQKTKKGFYQYE
>Mature_284_residues
MKQTKLTLLGAGTMGSGITQLFAQYGFYVTLIDNLQSQLDKAKDTIAKNLHYLALTQNLESTHSIETILASITFTTKLDE
LKQSEYIIENITENWERKKALYQVLKKECSATCILGVNTSSIPITKIASLVDHPQRVIGVHFMNPAPMMPMVEVIKGYHT
DELTIEKTRTLLEQVHKKMIVVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
VLYSLETIYSELNDPKYRPCWLLRNMVDAGLLGQKTKKGFYQYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=31.4569536423841, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=31.740614334471, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=31.740614334471, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=29.1228070175439, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=29.7872340425532, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1787661, Length=280, Percent_Identity=32.1428571428571, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1788682, Length=218, Percent_Identity=35.3211009174312, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790281, Length=220, Percent_Identity=28.1818181818182, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=32.5259515570934, Blast_Score=170, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17563036, Length=292, Percent_Identity=33.5616438356164, Blast_Score=158, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=32.404181184669, Blast_Score=150, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=29.2857142857143, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=28.7234042553192, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=27.0462633451957, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=27.0462633451957, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=27.0462633451957, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=27.0462633451957, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193203623, Length=193, Percent_Identity=25.3886010362694, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533614, Length=193, Percent_Identity=25.3886010362694, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=29.2253521126761, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=29.2253521126761, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=29.4326241134752, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=29.7071129707113, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32177; Mature: 32177

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTKLTLLGAGTMGSGITQLFAQYGFYVTLIDNLQSQLDKAKDTIAKNLHYLALTQNLE
CCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHEEEECCCC
STHSIETILASITFTTKLDELKQSEYIIENITENWERKKALYQVLKKECSATCILGVNTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
SIPITKIASLVDHPQRVIGVHFMNPAPMMPMVEVIKGYHTDELTIEKTRTLLEQVHKKMI
CCHHHHHHHHHHCHHHHEEEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEE
VVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
EEECCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VLYSLETIYSELNDPKYRPCWLLRNMVDAGLLGQKTKKGFYQYE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure
MKQTKLTLLGAGTMGSGITQLFAQYGFYVTLIDNLQSQLDKAKDTIAKNLHYLALTQNLE
CCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHEEEECCCC
STHSIETILASITFTTKLDELKQSEYIIENITENWERKKALYQVLKKECSATCILGVNTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
SIPITKIASLVDHPQRVIGVHFMNPAPMMPMVEVIKGYHTDELTIEKTRTLLEQVHKKMI
CCHHHHHHHHHHCHHHHEEEEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEE
VVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
EEECCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VLYSLETIYSELNDPKYRPCWLLRNMVDAGLLGQKTKKGFYQYE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]