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The map label for this gene is sppA [H]

Identifier: 148359293

GI number: 148359293

Start: 2030081

End: 2031037

Strand: Reverse

Name: sppA [H]

Synonym: LPC_1189

Alternate gene names: 148359293

Gene position: 2031037-2030081 (Counterclockwise)

Preceding gene: 148359295

Following gene: 148359291

Centisome position: 56.79

GC content: 36.89

Gene sequence:

>957_bases
ATGAATAATGAGTCATCTTCTAATTCTAATTTGGATTCACAAGCTTTGCTTAATCAATTGGTAATTGACTATCTCCAAGA
AAGGAAAAGAAAGCGTCGATGGAAATGGATTATAAGAGCTATTATCCTGGTCGTATTAGTTTATTCATCTTATAAGATTG
TTTCAGTCGCCAAAACCACGGAAGCATCTAAGGATAAAGAGCATATTGGACTAATTGATATTAACGGTGAAATTGCTGAT
TCCAGTTCAGCAAGTGCTGATAATTTCACTAAAGGAATTGAGAAGGCTTATAAAAGTAAAGGATTAAAAGCATTAATTGT
ACGGATAAATAGCCCTGGAGGCAGTCCTGTACAGGCGGAATATATTTATAATGTTTTACAATATTATAAAAGTCTAAAAC
CAAACATTAAAACTTACGCTGTTTGTGTCGATATGTGTGCTTCTGCTGCCTATTATGTTGCAGTTGGAGCAGATGAAATC
TATGCAAGTCCTGCAAGCATGGTCGGCTCAATAGGTGTTTTATATAATGGCTTTGGTTTTGTTGATGCATTGCAGAAGCT
TGGTATTTCACGCAGATTACAAACTTCAGGAGTCAATAAAGCTTTCCTGGACCCTTTTTCCCCAACGACTGAATTTCAGA
AAGAAAAGCTACAAACCATGCTTGATATAGTTCATAAGCAATTTATTACTCGTGTCAAAGAAGGAAGAGGAAATAGATTA
CATGTTGATGATGAGACTTTTTCCGGGTTATTTTGGACTGGCGAGCAAGCGTTGGCTAATGGTTTAATTGATGGTTATGC
CAGTAGCGGGCAGTTGGCGCGAGAGGTAATTAAAATTACTGATATAGTTGACTATACTTACAAGCAAAATGTCTTTGACC
GCCTAACTAAAAATTTGGGCACGGCGATGGCAGATGAGTTGCCAGTAATTTTAGGAATGAAGCCAGGATTAAGATAA

Upstream 100 bases:

>100_bases
GTCCATTCGCATAGGAACACCTTTCTAGTTATTTTAGGGTATTAATTCTAGTTTACATGCCATAAAATGGGTATTATTTA
CATTTTTTCAAGAGTTTTTT

Downstream 100 bases:

>100_bases
GAGTGGAGAGGAGTATTTATCCGCTTTCTCAGCTTCGAGAGAGCGGATATTCGAAAATAATTTAAAATCGATAAGCCTAA
ATGAACGTCTTAAATGAGCT

Product: signal peptide peptidase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILVVLVYSSYKIVSVAKTTEASKDKEHIGLIDINGEIAD
SSSASADNFTKGIEKAYKSKGLKALIVRINSPGGSPVQAEYIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEI
YASPASMVGSIGVLYNGFGFVDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HVDDETFSGLFWTGEQALANGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLGTAMADELPVILGMKPGLR

Sequences:

>Translated_318_residues
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILVVLVYSSYKIVSVAKTTEASKDKEHIGLIDINGEIAD
SSSASADNFTKGIEKAYKSKGLKALIVRINSPGGSPVQAEYIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEI
YASPASMVGSIGVLYNGFGFVDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HVDDETFSGLFWTGEQALANGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLGTAMADELPVILGMKPGLR
>Mature_318_residues
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILVVLVYSSYKIVSVAKTTEASKDKEHIGLIDINGEIAD
SSSASADNFTKGIEKAYKSKGLKALIVRINSPGGSPVQAEYIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEI
YASPASMVGSIGVLYNGFGFVDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HVDDETFSGLFWTGEQALANGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLGTAMADELPVILGMKPGLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=257, Percent_Identity=28.4046692607004, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787527, Length=237, Percent_Identity=27.0042194092827, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35250; Mature: 35250

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILVVLVYSSYKIVSVAKTT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHH
EASKDKEHIGLIDINGEIADSSSASADNFTKGIEKAYKSKGLKALIVRINSPGGSPVQAE
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHH
YIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEIYASPASMVGSIGVLYNGFGF
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCHHHHCCHHHHHHHHHHHHCCCCH
VDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HHHHHHCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
HVDDETFSGLFWTGEQALANGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLG
EECCCCCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAMADELPVILGMKPGLR
HHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MNNESSSNSNLDSQALLNQLVIDYLQERKRKRRWKWIIRAIILVVLVYSSYKIVSVAKTT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHH
EASKDKEHIGLIDINGEIADSSSASADNFTKGIEKAYKSKGLKALIVRINSPGGSPVQAE
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHH
YIYNVLQYYKSLKPNIKTYAVCVDMCASAAYYVAVGADEIYASPASMVGSIGVLYNGFGF
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCHHHHCCHHHHHHHHHHHHCCCCH
VDALQKLGISRRLQTSGVNKAFLDPFSPTTEFQKEKLQTMLDIVHKQFITRVKEGRGNRL
HHHHHHCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
HVDDETFSGLFWTGEQALANGLIDGYASSGQLAREVIKITDIVDYTYKQNVFDRLTKNLG
EECCCCCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAMADELPVILGMKPGLR
HHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA