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The map label for this gene is purD [H]

Identifier: 148359210

GI number: 148359210

Start: 1930675

End: 1931994

Strand: Reverse

Name: purD [H]

Synonym: LPC_1104

Alternate gene names: 148359210

Gene position: 1931994-1930675 (Counterclockwise)

Preceding gene: 148359211

Following gene: 148359209

Centisome position: 54.02

GC content: 39.09

Gene sequence:

>1320_bases
TTGATCAATATCCTTATTGTTGGTTCAGGTGCGCGTGAGCATGCAATAGCTACAGCATTGAGTAAATCAGAGAATAAACC
AAAGATTTATTGCTTTGGAACAACTCGTAATCCTGGTATCCAAAGACTCACCTCAGATTATTGGGTAGGTGATATTACAG
ACCCTGAGCAAGTTAACCAGCAAGCAAAAGAATGGGAAATTAATTTGGCCATTATTGGTCCAGAAGCGCCTTTGGAACAT
GCTGTTGCTGATGCTTTGTGGGATTGTGGAATTCCTGTTATAGGCCCCAGGAAAAATTTGGCTAAAATTGAAACCAGTAA
AGCGTTCGCCAGAGAGTTGATGGAAAAATACGGTATTCCAGGTTTGCCTAAGTATAAAGTATTTACCAGTTTAGAGGGAA
TAGGGGAGTTTTTATCAGAGTTAGGTGAAAATAATTACGTTGTTAAGGCCAATGGTTTAATGGCGGGCAAGGGTGTAAAA
GTAGGTGGAGAACATCTGTTGTCATTTGAAGAGGCTTTAAACTATTGTAAAGAAATTTTTACTCATAATCAGTCTTTAGT
CATTGAAGAAAAATTAATAGGTCAAGAATTTTCATTTATGTGTTTTTCTGATGGCATCTCATTAGTTCCAATGCCTATTG
TGCAAGATCATAAACGAGCTTATGAGCATGATGAGGGTCCTAATACAGGTGGTATGGGGAGTTATTCAGCGGCAGATCAC
AGCTTGCCATTTTTGTCTCCAGAGGATGTTCGTGCTGCTTTTGAAATTAATCAATCAGTAATCAAAGCGCTTATGACGGA
AATGTCTGATAAATACATAGGAATACTTTATGGCGGATTTATGGCCACCGCACATGGGGTGTATGTGATTGAGTTTAATG
CTCGCTTTGGAGATCCTGAGGCTCTTAACGTGCTTAGCTTGTTGGAATCTGATTTTGTTAAATTATGTGTTGCGATGGCT
AACGGCAATTTACAAAAAGAATCCGTTCGCTTTTTGAATCAAGCCACAGTTTGTAAATACGCTGTCCCTGATGGTTATCC
TGATAATCCATTGCGCCATGTTGAAATTGATATTTCTGCTGTCGAACCTAAAGATACTCTATATTTGGCTGCAGTGAATT
TTAAGAATGGCAAACTCTATGCCACAGGTTCGAGGACAGCCGCTTATGTCGGTATAGCGAATACTATCAGTGAGGCAGAA
GAAATTGCTGAACAACAGATAAAAAATATAAAAGGCCCTTTATTTCACAGAAAAGATATTGGCACATCGCCTTTAATTAA
TACACGCGTTGAAGTAATGCGTAGGTTGCGTGCCTTATGA

Upstream 100 bases:

>100_bases
GTAAATACATTTGTGGACAGATTACTGAAGAAAAAATTAAATTGTTGGAGAAAAAAAGATTAACCGAGAATGACCAAGAA
ACAGAGATAGGAGAGATGTC

Downstream 100 bases:

>100_bases
TTCGTTTAGGAATATTAGGATCGACTCGTGGAACCAATATGTTGGCTCTTGTTGATGCAATCAATGAGGGAACTCTTAAG
GCAAAGATAGAGCTTGTTAT

Product: phosphoribosylamine-glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQQAKEWEINLAIIGPEAPLEH
AVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIPGLPKYKVFTSLEGIGEFLSELGENNYVVKANGLMAGKGVK
VGGEHLLSFEEALNYCKEIFTHNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
SLPFLSPEDVRAAFEINQSVIKALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPEALNVLSLLESDFVKLCVAMA
NGNLQKESVRFLNQATVCKYAVPDGYPDNPLRHVEIDISAVEPKDTLYLAAVNFKNGKLYATGSRTAAYVGIANTISEAE
EIAEQQIKNIKGPLFHRKDIGTSPLINTRVEVMRRLRAL

Sequences:

>Translated_439_residues
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQQAKEWEINLAIIGPEAPLEH
AVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIPGLPKYKVFTSLEGIGEFLSELGENNYVVKANGLMAGKGVK
VGGEHLLSFEEALNYCKEIFTHNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
SLPFLSPEDVRAAFEINQSVIKALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPEALNVLSLLESDFVKLCVAMA
NGNLQKESVRFLNQATVCKYAVPDGYPDNPLRHVEIDISAVEPKDTLYLAAVNFKNGKLYATGSRTAAYVGIANTISEAE
EIAEQQIKNIKGPLFHRKDIGTSPLINTRVEVMRRLRAL
>Mature_439_residues
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQQAKEWEINLAIIGPEAPLEH
AVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIPGLPKYKVFTSLEGIGEFLSELGENNYVVKANGLMAGKGVK
VGGEHLLSFEEALNYCKEIFTHNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
SLPFLSPEDVRAAFEINQSVIKALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPEALNVLSLLESDFVKLCVAMA
NGNLQKESVRFLNQATVCKYAVPDGYPDNPLRHVEIDISAVEPKDTLYLAAVNFKNGKLYATGSRTAAYVGIANTISEAE
EIAEQQIKNIKGPLFHRKDIGTSPLINTRVEVMRRLRAL

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=433, Percent_Identity=35.3348729792148, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI209869995, Length=433, Percent_Identity=35.3348729792148, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI209869993, Length=433, Percent_Identity=35.3348729792148, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI28416899, Length=433, Percent_Identity=35.3348729792148, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1790438, Length=445, Percent_Identity=32.5842696629214, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17567511, Length=436, Percent_Identity=33.4862385321101, Blast_Score=194, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6321203, Length=455, Percent_Identity=30.1098901098901, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24582400, Length=362, Percent_Identity=37.0165745856354, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI62471619, Length=427, Percent_Identity=34.4262295081967, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 48311; Mature: 48311

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQ
CEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHH
QAKEWEINLAIIGPEAPLEHAVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIP
HHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GLPKYKVFTSLEGIGEFLSELGENNYVVKANGLMAGKGVKVGGEHLLSFEEALNYCKEIF
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHH
THNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
HCCCCEEEHHHHCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
SLPFLSPEDVRAAFEINQSVIKALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCEEEEEEECCCCCHH
ALNVLSLLESDFVKLCVAMANGNLQKESVRFLNQATVCKYAVPDGYPDNPLRHVEIDISA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEEEEE
VEPKDTLYLAAVNFKNGKLYATGSRTAAYVGIANTISEAEEIAEQQIKNIKGPLFHRKDI
ECCCCEEEEEEEEECCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GTSPLINTRVEVMRRLRAL
CCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MINILIVGSGAREHAIATALSKSENKPKIYCFGTTRNPGIQRLTSDYWVGDITDPEQVNQ
CEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHH
QAKEWEINLAIIGPEAPLEHAVADALWDCGIPVIGPRKNLAKIETSKAFARELMEKYGIP
HHHHEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GLPKYKVFTSLEGIGEFLSELGENNYVVKANGLMAGKGVKVGGEHLLSFEEALNYCKEIF
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHH
THNQSLVIEEKLIGQEFSFMCFSDGISLVPMPIVQDHKRAYEHDEGPNTGGMGSYSAADH
HCCCCEEEHHHHCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
SLPFLSPEDVRAAFEINQSVIKALMTEMSDKYIGILYGGFMATAHGVYVIEFNARFGDPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCEEEEEEECCCCCHH
ALNVLSLLESDFVKLCVAMANGNLQKESVRFLNQATVCKYAVPDGYPDNPLRHVEIDISA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEEEEE
VEPKDTLYLAAVNFKNGKLYATGSRTAAYVGIANTISEAEEIAEQQIKNIKGPLFHRKDI
ECCCCEEEEEEEEECCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GTSPLINTRVEVMRRLRAL
CCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA