| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is pbpC [H]
Identifier: 148359200
GI number: 148359200
Start: 1910858
End: 1913164
Strand: Reverse
Name: pbpC [H]
Synonym: LPC_1094
Alternate gene names: 148359200
Gene position: 1913164-1910858 (Counterclockwise)
Preceding gene: 148359202
Following gene: 148359197
Centisome position: 53.49
GC content: 37.67
Gene sequence:
>2307_bases ATGAGAAAAGTAATAAAATATCTTAGCATAATCTTGGGTTCGCTATTTGTCAGTGGGTTTTTATTATTATTTTTTTCTCC CAAACCTTCTTTATTAGAAGAATTCAATTTTTCTAAAGCGGTATATGATGATAATCAACAATTATTAAGATTAATTTTAA GTGAAGATGACAAATACAGACTTTATGTACCGTTATCTCAAATACCCAAGGAGCTAATGGAGGCCACACTTTTACAAGAA GATCAGTATTTTCCCTGGCATAAAGGAGTAAACCCTTTTTCCATGGTGAAAGCGATTTGGCAAACTTATGTGGTTAAATC GCGCAGAATCGGGGCTTCAACAATCACAATGCAGGTGGCACGAATTCGTTTTGGAATTAACTCCAAGAAAATTTCTGGAA AATTATGGCAAATTATTAGGGCGTTACAAATAGAGCGTCATTATGATAAAGATAAAATTCTTGAGGCTTATTTCAATTTG GCACCTTATGGTGGAAATATAGAGGGAGTAGGGGCGGCGAGCTTAATTTATTTTAATAAGCCTGTTAGTAAACTTGGTTT ACCAGAGGCACTAACTTTAAGCATTATCCCTCAAAATCCAGTAAAAAGGACATCAAAAAACAGTGAATTAAAAAAAATAA GAAATCGTTTATTTGCCAGATGGCTGAAGCAGCATCCGCAAGACCAGGAGAAGCAACCTCTGTTTGGACTGCCTTTAGTT ATGCAAACGAATCAAAACCTACCCTTCCTGGCTCCTCATTTTGTAAATATGGTACTGAAGGAAAATCCTGGTTTATCACA AAGTATTTCAACAACTTTGGATTACAGGCTTCAGTTAATAGTTGAGCGAATTACAAGGCATTATTTAGCAAGAAAAAAAA TGTTTGGTGTTCACAACGCGGCGGTATTACTTGTGGATAGCCGTACTATGAGTATTAAAGCGTTGATGGGATCTGCTGAT TTTTTTAATAATAAGATAAGTGGACAAATCAATGGTGTAGAAACCAAAAGGTCACCTGGCTCAACTCTGAAACCATTTAT TTATGGATTAGCCCTTGATCAAGGTTTAATTCACCCCAATACAGTTTTAAAGGATGTACCACAGAGTTTTAATGGTTATA ATCCGGAAAACTTCGATTATGATTTTATGGGACCCATCAAAGCAAAAGATGCTTTGGTACTTAGTCGTAATATCCCGGCC ATCGAGCTTTCCAATCAATTAACTAATCCAACATTACATAAATTACTTGAACAGGCGCATGTAACTCAGTTGCGTTCCGA ATCATATTATGGCTTGTCTCTTAATTTGGGTGGTGTTGAACTTACTATGAAAGAGTTAGTCGGTTTATATGCTATGCTGA TTAATGATGGGGTCTGGTATCCAATCAATTCATTAAAAGGGGTTCCGCGACAAAAAGGTCGACGCTTGCTTAGCACAGAA GCAAGCTTTTTAGTTTTCGATATGCTAAAAAATACTCCAATGAAAGAGTCGAATAATGAGGGCAGCTCACAATTACCAAT TGCCTGGAAAACAGGAACTTCCTCAGGATACAGAGATGCCTGGACAGTTGGAGTTTTTGGTCCTTATGTATTGGCAGTTT GGATAGGAAATTTTGATAATCAGGCAAATCCGGCTTTTATAGGTAAAGAAATTGCTGCGCCTTTATTTTTTGAATTGATT GATGCAATAAAACATGAAAGAGGACCAATAGCTCGAGTTGAAAAATACCCTGAACACATGCATTTGGAAAAAATAGAAGT ATGCAAAGCCTCAGGTATGCTTCCTGGTCGATATTGTACGGATACAGAATGGACCTGGTTTATTCCAGGTAAATCTCCTA TTAAAACGGATACAATTTTTCGAGAGGTGGCAATTAACGGTAAGACGGGGCTTCGTACTTGTCACATCGATGAAAATACT CGTTTTGAAGTGTATGAGTTTTGGCCCTCCGATTTATTAAGAATATTCAGGAGGGCAGGGATTCAACGCCATACCCCGCC ATTTTTTGAACCAGGTTGTGCTTTGTCGGGAAATAGTGGTATTAGCCCCCAAATTACATCTCCCCAGGCAGGGGTAAGTT ATATTGTCCATGCTAATACCCAATCAAACAAGATAATCCCATTAACTGCGGTAACAGATGCTGGAATTGCACATTTATAC TGGTTTATCAATGAAAGTTTTGTAGCTGAAACAAAATCAGATGAACCTTATCTCTGGCAGGCGAAACCTGGTAAATATGT GGTAAGGGTGGTAGATGACCGTGGTTTATCTGATGCGCGGGATATTATTATTCAGATGGTTAGTTGA
Upstream 100 bases:
>100_bases TTATTAATTTATAATTATTAGTCTATCCTTTGCCAATTCTAATGCATTTCAATATTAATTTGAATATAATTTAACCTTTA TATCATCCCTGTTGTGGGCA
Downstream 100 bases:
>100_bases CGCATATTTGATGATGTATAAGTGATCCCTTGTCCTAATCGGAGCAAGGGATTTAAAATTAAACTGAGGCCGAGTTTCTT GACTCTTCATCTTCGTTCTC
Product: penicillin binding protein 1C
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 768; Mature: 768
Protein sequence:
>768_residues MRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSEDDKYRLYVPLSQIPKELMEATLLQE DQYFPWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVARIRFGINSKKISGKLWQIIRALQIERHYDKDKILEAYFNL APYGGNIEGVGAASLIYFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFGLPLV MQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNAAVLLVDSRTMSIKALMGSAD FFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPA IELSNQLTNPTLHKLLEQAHVTQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRRLLSTE ASFLVFDMLKNTPMKESNNEGSSQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDNQANPAFIGKEIAAPLFFELI DAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENT RFEVYEFWPSDLLRIFRRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGIAHLY WFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDIIIQMVS
Sequences:
>Translated_768_residues MRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSEDDKYRLYVPLSQIPKELMEATLLQE DQYFPWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVARIRFGINSKKISGKLWQIIRALQIERHYDKDKILEAYFNL APYGGNIEGVGAASLIYFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFGLPLV MQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNAAVLLVDSRTMSIKALMGSAD FFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPA IELSNQLTNPTLHKLLEQAHVTQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRRLLSTE ASFLVFDMLKNTPMKESNNEGSSQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDNQANPAFIGKEIAAPLFFELI DAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENT RFEVYEFWPSDLLRIFRRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGIAHLY WFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDIIIQMVS >Mature_768_residues MRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSEDDKYRLYVPLSQIPKELMEATLLQE DQYFPWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVARIRFGINSKKISGKLWQIIRALQIERHYDKDKILEAYFNL APYGGNIEGVGAASLIYFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFGLPLV MQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNAAVLLVDSRTMSIKALMGSAD FFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPA IELSNQLTNPTLHKLLEQAHVTQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRRLLSTE ASFLVFDMLKNTPMKESNNEGSSQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDNQANPAFIGKEIAAPLFFELI DAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENT RFEVYEFWPSDLLRIFRRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGIAHLY WFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDIIIQMVS
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=750, Percent_Identity=30.2666666666667, Blast_Score=295, Evalue=8e-81, Organism=Escherichia coli, GI1786343, Length=535, Percent_Identity=26.1682242990654, Blast_Score=135, Evalue=9e-33, Organism=Escherichia coli, GI87082258, Length=218, Percent_Identity=32.1100917431193, Blast_Score=91, Evalue=2e-19, Organism=Escherichia coli, GI1789601, Length=204, Percent_Identity=29.9019607843137, Blast_Score=81, Evalue=3e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.- [C]
Molecular weight: Translated: 86871; Mature: 86871
Theoretical pI: Translated: 9.77; Mature: 9.77
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSEDDKYR CHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCCCCHHEECCCHHHHHHHHCCCCCEE LYVPLSQIPKELMEATLLQEDQYFPWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVA EEEEHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHEEE RIRFGINSKKISGKLWQIIRALQIERHYDKDKILEAYFNLAPYGGNIEGVGAASLIYFNK HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC PVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFGLPLV CHHHHCCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE MQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNA EECCCCCCEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE AVLLVDSRTMSIKALMGSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPN EEEEEECCCEEEEEECCCHHHHCCCCCCEECCEECCCCCCCCHHHHHHHHHHCCCCCCCH TVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPAIELSNQLTNPTLHKLLEQAH HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHH VTQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRRLLSTE HHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCHHHCCHHHHCC ASFLVFDMLKNTPMKESNNEGSSQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDN HHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHEEEEHEECCCCC QANPAFIGKEIAAPLFFELIDAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCT CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCHHHHHHHHHCCCCCCCEEC DTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENTRFEVYEFWPSDLLRIFRRAG CCCEEEEECCCCCCCHHHHHHHHEECCCCCCEEEEECCCCCEEEEEECHHHHHHHHHHCC IQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGIAHLY CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCHHHHH WFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDIIIQMVS HHHCCHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHCCC >Mature Secondary Structure MRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSEDDKYR CHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCCCCHHEECCCHHHHHHHHCCCCCEE LYVPLSQIPKELMEATLLQEDQYFPWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVA EEEEHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHEEE RIRFGINSKKISGKLWQIIRALQIERHYDKDKILEAYFNLAPYGGNIEGVGAASLIYFNK HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC PVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFGLPLV CHHHHCCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE MQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNA EECCCCCCEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE AVLLVDSRTMSIKALMGSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPN EEEEEECCCEEEEEECCCHHHHCCCCCCEECCEECCCCCCCCHHHHHHHHHHCCCCCCCH TVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPAIELSNQLTNPTLHKLLEQAH HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHH VTQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRRLLSTE HHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCHHHCCHHHHCC ASFLVFDMLKNTPMKESNNEGSSQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDN HHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHEEEEHEECCCCC QANPAFIGKEIAAPLFFELIDAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCT CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCHHHHHHHHHCCCCCCCEEC DTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENTRFEVYEFWPSDLLRIFRRAG CCCEEEEECCCCCCCHHHHHHHHEECCCCCCEEEEECCCCCEEEEEECHHHHHHHHHHCC IQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGIAHLY CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCHHHHH WFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDIIIQMVS HHHCCHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]