Click here to switch to the map view.

The map label for this gene is pacS [H]

Identifier: 148358573

GI number: 148358573

Start: 3218590

End: 3221133

Strand: Direct

Name: pacS [H]

Synonym: LPC_0445

Alternate gene names: 148358573

Gene position: 3218590-3221133 (Clockwise)

Preceding gene: 148358575

Following gene: 148358572

Centisome position: 89.99

GC content: 39.78

Gene sequence:

>2544_bases
ATGTCCAAACCTTATTTTTTTTATGTCAGCGGAATGAATTGCACCAGTTGCAGCAATGCTATAGAGTCCTTTTTAAGAAA
CTCCAATTTAATCAAAATCAATACATTTCATGCGGACATGAGCACTCCGGATCCCAAAAAAATTGTGATATCTCTTTCCG
AAGAAAAGGAAAATGAACATGAAAGCAACTGGAAAACCATTAAAAAATTAATTGATGACACAGGTTTTACTTGCGAAAAT
TATGAATCCCCTCAAATGAAAGATCAAAAACCCGCTCTTCCTCTCGAGAAAACGCAGACAACCGTTCAACAGGAAGCCAC
CCAATTATCCGCACTCTTTAGCAGCGCAAAAAAAATAATCAGCTCCCATTGGTTGCTTGGAGGATTGGGTTGTATCACCG
GAGTTAGCTTAATGATCCTGACTATGGCGATAGGTGGTTTACCTCTTGCGCTAATGATTCCTTTAGCGGGCCTCAGCACT
TTATTAACTATTGCGCTTGGTGCCCAATCTTATTACGAGGCTTGGAAAAAGTTAGTCCACTCTCGCACACTCACAATGGA
CACATTGTTTTCAATTAGCACTATTTCTGTTCTTATTGTGTCGCTTGCTTCATTCTTTGTACCGTGGTTGCCTATGATGT
TTGAGGCAGGATTACTTATTTATGGATTCAGGCATATTGGTATCGCTATTGAGGACACTATCAAAGACAAAATAAGCTCC
GCCAAATTTCAAGACAGAGCCCCGCAAAAAGTCAGATTATATCGCCATCCTGATTTTAAAAAAACGAGGATTGATGAGAT
TCAACCCAACGACATTATACAAGTCAAACCAGGTGAGCTTGTACCATTGGATAGCGTTTGTGAGCAAGACACCCTTATTT
ATCCCACCATCATTACCGGTGCTGTCATACCTAAACAATTTCGTAGTGGTGAAAAAATACTTGCCGGAATGCGTCTGGCA
AATGATGCAAAACCACTCACCCTCCGCGTTCTAAAAACTGCAAAAGAGTCATACCTTGCCCGTCTTGATGAAAGCATAGC
CCAATCTGTACTTGAAAAGGCACCGATAGAGGTAAAAACAGGGCAGCTTCTTAGCTATTTTATCCCATCCATTATTGCTC
TCTCCATCCTTTCAGGGATCATTGTCGGCTTGATTGCCACACCAGCACTTGCGATACAATGCGCTATTTCAGTGTTGGTT
TCTGCTTGTCCTTGTACGCTTGGTTTAATTATTCCTCTAGCAGTAAAAACTGGAATTCATAAAGGAGCCGAACACGGTGT
GCGGTTTAAAAATTCCAGGGTATTACAATTAGCAGAACAAATTGATGTAGTCATTTTTGACTTGAATGGCACTTTAACAA
CCGGCGTTCCTGTGGTTAACGAATATGCTGTATTAAATGATGCTGATCTTTCTTCTGAGCAATTTCTGAGTATTTGCAAT
GTGTTGGAAGAACAATCAAAACACCCTTTCGGCAAAGCAATACAATCGTTTACCCAAGGAATCAATAAACAAAAATTCAA
TATTGCTAATTTGGATCATTCGAACCATTCAGGCATTTCAGCAGAGATTAATGGTATTCAATATACTATTGGCAGTAAAA
CCTTAATGCAGGAAATAGGGATTTCTACATCTTCGCTTGAAAACCAAATGAACCTGGTTGCGGGCGATAGCCTGGTGTTT
CTAGCCAGAAACAAACAACTATTGGGTTATCTGGTCATCACCGACCCCTTACGAAAAGATGCAAAGCAAACAGTTGATGC
TTTAATTAAAATGGGAAAAGAAGTGCATCTATGCACTGGTGCAGATGAAAAAACCGCTTATCGCTATGCGCAAGCTCTTG
GCATTAAGAAGGTACATGCTAATTGTGTCGCTACAACTATCAATACAGAAGATAGATCCAAACCAGTTTATATTAAATCA
TTACAAAATCAGGGACTAAAAGTAGCTATGATTGGAGATGCGGCTAATGACGCAAACGCCCTTGCTGCGAGCGACTTCGG
TATAGCTGTACTGTCTCAAGACAGCGATGAAATCACCCAACAACACGCCTCAGCCATTATACAAAGTGGAACTATATTGC
CTATAGCCAATGCCTTTGCCATATCAAAACAAACAGTAAACAATATCAATCAGAATTTGTTAATTAGCTTAGGGTACAAT
TTGACAACAGTATTAATAGCCGGTGGTCTGTTAGTCACCCTTGGTTTTGTGCTGAATCCTGCTGTTGGTGTGGCATTAAT
GGTAACCCAGGCTTGTTTTGTCTTGCTCAATGTATACCGCTTTAAAGAGCAACCCTTGCAACATTTGCAAGACAAAGTTC
AGGAAAAACCAGAACCGGCTCCTTCTTCTTATGAAGCCATGAAAAAGCATTCACCCAATTTCCATACAGCTCCCGAGATT
AATCATAATTCAGTCATTCAATCTGGAAAGCAGACGATTAATAAAAATAAATCACCTTCCTTTTGGAGTGATTATTTTCC
TGAATTATTTGAAGAAGAAAAGGACACAGGTACCGAACATCTAATGAATAACAAAATAGGATAA

Upstream 100 bases:

>100_bases
TAGGCCTTGATTTAAAACCCCTACTCAATGGTCGGTGTTGATTGATAAATCCGGTACAAAGTTCTCAGGATGAGTTAACC
ATTTAACTCAGCGAGCTATT

Downstream 100 bases:

>100_bases
GCCCTAAATAAAGCTTGGCTGAATTTGAAATGGGGAAGGCCAATCACCCTCCTCAATCATAACAATCAATTTTGATTTAT
TATGCTCTAAAGTGTCAAGA

Product: cation transporting ATPase PacS

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 847; Mature: 846

Protein sequence:

>847_residues
MSKPYFFYVSGMNCTSCSNAIESFLRNSNLIKINTFHADMSTPDPKKIVISLSEEKENEHESNWKTIKKLIDDTGFTCEN
YESPQMKDQKPALPLEKTQTTVQQEATQLSALFSSAKKIISSHWLLGGLGCITGVSLMILTMAIGGLPLALMIPLAGLST
LLTIALGAQSYYEAWKKLVHSRTLTMDTLFSISTISVLIVSLASFFVPWLPMMFEAGLLIYGFRHIGIAIEDTIKDKISS
AKFQDRAPQKVRLYRHPDFKKTRIDEIQPNDIIQVKPGELVPLDSVCEQDTLIYPTIITGAVIPKQFRSGEKILAGMRLA
NDAKPLTLRVLKTAKESYLARLDESIAQSVLEKAPIEVKTGQLLSYFIPSIIALSILSGIIVGLIATPALAIQCAISVLV
SACPCTLGLIIPLAVKTGIHKGAEHGVRFKNSRVLQLAEQIDVVIFDLNGTLTTGVPVVNEYAVLNDADLSSEQFLSICN
VLEEQSKHPFGKAIQSFTQGINKQKFNIANLDHSNHSGISAEINGIQYTIGSKTLMQEIGISTSSLENQMNLVAGDSLVF
LARNKQLLGYLVITDPLRKDAKQTVDALIKMGKEVHLCTGADEKTAYRYAQALGIKKVHANCVATTINTEDRSKPVYIKS
LQNQGLKVAMIGDAANDANALAASDFGIAVLSQDSDEITQQHASAIIQSGTILPIANAFAISKQTVNNINQNLLISLGYN
LTTVLIAGGLLVTLGFVLNPAVGVALMVTQACFVLLNVYRFKEQPLQHLQDKVQEKPEPAPSSYEAMKKHSPNFHTAPEI
NHNSVIQSGKQTINKNKSPSFWSDYFPELFEEEKDTGTEHLMNNKIG

Sequences:

>Translated_847_residues
MSKPYFFYVSGMNCTSCSNAIESFLRNSNLIKINTFHADMSTPDPKKIVISLSEEKENEHESNWKTIKKLIDDTGFTCEN
YESPQMKDQKPALPLEKTQTTVQQEATQLSALFSSAKKIISSHWLLGGLGCITGVSLMILTMAIGGLPLALMIPLAGLST
LLTIALGAQSYYEAWKKLVHSRTLTMDTLFSISTISVLIVSLASFFVPWLPMMFEAGLLIYGFRHIGIAIEDTIKDKISS
AKFQDRAPQKVRLYRHPDFKKTRIDEIQPNDIIQVKPGELVPLDSVCEQDTLIYPTIITGAVIPKQFRSGEKILAGMRLA
NDAKPLTLRVLKTAKESYLARLDESIAQSVLEKAPIEVKTGQLLSYFIPSIIALSILSGIIVGLIATPALAIQCAISVLV
SACPCTLGLIIPLAVKTGIHKGAEHGVRFKNSRVLQLAEQIDVVIFDLNGTLTTGVPVVNEYAVLNDADLSSEQFLSICN
VLEEQSKHPFGKAIQSFTQGINKQKFNIANLDHSNHSGISAEINGIQYTIGSKTLMQEIGISTSSLENQMNLVAGDSLVF
LARNKQLLGYLVITDPLRKDAKQTVDALIKMGKEVHLCTGADEKTAYRYAQALGIKKVHANCVATTINTEDRSKPVYIKS
LQNQGLKVAMIGDAANDANALAASDFGIAVLSQDSDEITQQHASAIIQSGTILPIANAFAISKQTVNNINQNLLISLGYN
LTTVLIAGGLLVTLGFVLNPAVGVALMVTQACFVLLNVYRFKEQPLQHLQDKVQEKPEPAPSSYEAMKKHSPNFHTAPEI
NHNSVIQSGKQTINKNKSPSFWSDYFPELFEEEKDTGTEHLMNNKIG
>Mature_846_residues
SKPYFFYVSGMNCTSCSNAIESFLRNSNLIKINTFHADMSTPDPKKIVISLSEEKENEHESNWKTIKKLIDDTGFTCENY
ESPQMKDQKPALPLEKTQTTVQQEATQLSALFSSAKKIISSHWLLGGLGCITGVSLMILTMAIGGLPLALMIPLAGLSTL
LTIALGAQSYYEAWKKLVHSRTLTMDTLFSISTISVLIVSLASFFVPWLPMMFEAGLLIYGFRHIGIAIEDTIKDKISSA
KFQDRAPQKVRLYRHPDFKKTRIDEIQPNDIIQVKPGELVPLDSVCEQDTLIYPTIITGAVIPKQFRSGEKILAGMRLAN
DAKPLTLRVLKTAKESYLARLDESIAQSVLEKAPIEVKTGQLLSYFIPSIIALSILSGIIVGLIATPALAIQCAISVLVS
ACPCTLGLIIPLAVKTGIHKGAEHGVRFKNSRVLQLAEQIDVVIFDLNGTLTTGVPVVNEYAVLNDADLSSEQFLSICNV
LEEQSKHPFGKAIQSFTQGINKQKFNIANLDHSNHSGISAEINGIQYTIGSKTLMQEIGISTSSLENQMNLVAGDSLVFL
ARNKQLLGYLVITDPLRKDAKQTVDALIKMGKEVHLCTGADEKTAYRYAQALGIKKVHANCVATTINTEDRSKPVYIKSL
QNQGLKVAMIGDAANDANALAASDFGIAVLSQDSDEITQQHASAIIQSGTILPIANAFAISKQTVNNINQNLLISLGYNL
TTVLIAGGLLVTLGFVLNPAVGVALMVTQACFVLLNVYRFKEQPLQHLQDKVQEKPEPAPSSYEAMKKHSPNFHTAPEIN
HNSVIQSGKQTINKNKSPSFWSDYFPELFEEEKDTGTEHLMNNKIG

Specific function: May play a role in the osmotic adaptation [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=666, Percent_Identity=27.7777777777778, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI115529486, Length=687, Percent_Identity=27.6564774381368, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI55743073, Length=558, Percent_Identity=27.2401433691756, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI48762689, Length=211, Percent_Identity=29.8578199052133, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI48762685, Length=211, Percent_Identity=29.8578199052133, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI48762691, Length=211, Percent_Identity=29.8578199052133, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI48762687, Length=211, Percent_Identity=29.8578199052133, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786691, Length=771, Percent_Identity=27.1076523994812, Blast_Score=232, Evalue=8e-62,
Organism=Escherichia coli, GI1789879, Length=740, Percent_Identity=24.1891891891892, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1786914, Length=459, Percent_Identity=24.400871459695, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17556548, Length=675, Percent_Identity=25.9259259259259, Blast_Score=175, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320475, Length=639, Percent_Identity=30.2034428794992, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319772, Length=802, Percent_Identity=23.8154613466334, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI221329854, Length=593, Percent_Identity=25.2951096121417, Blast_Score=116, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 92676; Mature: 92545

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPYFFYVSGMNCTSCSNAIESFLRNSNLIKINTFHADMSTPDPKKIVISLSEEKENEH
CCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECHHCCCCH
ESNWKTIKKLIDDTGFTCENYESPQMKDQKPALPLEKTQTTVQQEATQLSALFSSAKKII
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SSHWLLGGLGCITGVSLMILTMAIGGLPLALMIPLAGLSTLLTIALGAQSYYEAWKKLVH
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SRTLTMDTLFSISTISVLIVSLASFFVPWLPMMFEAGLLIYGFRHIGIAIEDTIKDKISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHCEEEHHHHHHHHHH
AKFQDRAPQKVRLYRHPDFKKTRIDEIQPNDIIQVKPGELVPLDSVCEQDTLIYPTIITG
CHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCHHHHCCCCCEEEHHHHHH
AVIPKQFRSGEKILAGMRLANDAKPLTLRVLKTAKESYLARLDESIAQSVLEKAPIEVKT
HHCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEH
GQLLSYFIPSIIALSILSGIIVGLIATPALAIQCAISVLVSACPCTLGLIIPLAVKTGIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGAEHGVRFKNSRVLQLAEQIDVVIFDLNGTLTTGVPVVNEYAVLNDADLSSEQFLSICN
CCHHCCCEECCHHHHHHHHHCCEEEEECCCCEECCCCCCCCEEEECCCCCCHHHHHHHHH
VLEEQSKHPFGKAIQSFTQGINKQKFNIANLDHSNHSGISAEINGIQYTIGSKTLMQEIG
HHHHHCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEECCEEEECCHHHHHHHHC
ISTSSLENQMNLVAGDSLVFLARNKQLLGYLVITDPLRKDAKQTVDALIKMGKEVHLCTG
CCHHHHHHHHHEEECCCEEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHCCCEEEEECC
ADEKTAYRYAQALGIKKVHANCVATTINTEDRSKPVYIKSLQNQGLKVAMIGDAANDANA
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCCCC
LAASDFGIAVLSQDSDEITQQHASAIIQSGTILPIANAFAISKQTVNNINQNLLISLGYN
EEECCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCC
LTTVLIAGGLLVTLGFVLNPAVGVALMVTQACFVLLNVYRFKEQPLQHLQDKVQEKPEPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSSYEAMKKHSPNFHTAPEINHNSVIQSGKQTINKNKSPSFWSDYFPELFEEEKDTGTEH
CCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHH
LMNNKIG
HHCCCCC
>Mature Secondary Structure 
SKPYFFYVSGMNCTSCSNAIESFLRNSNLIKINTFHADMSTPDPKKIVISLSEEKENEH
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECHHCCCCH
ESNWKTIKKLIDDTGFTCENYESPQMKDQKPALPLEKTQTTVQQEATQLSALFSSAKKII
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SSHWLLGGLGCITGVSLMILTMAIGGLPLALMIPLAGLSTLLTIALGAQSYYEAWKKLVH
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SRTLTMDTLFSISTISVLIVSLASFFVPWLPMMFEAGLLIYGFRHIGIAIEDTIKDKISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHCEEEHHHHHHHHHH
AKFQDRAPQKVRLYRHPDFKKTRIDEIQPNDIIQVKPGELVPLDSVCEQDTLIYPTIITG
CHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCHHHHCCCCCEEEHHHHHH
AVIPKQFRSGEKILAGMRLANDAKPLTLRVLKTAKESYLARLDESIAQSVLEKAPIEVKT
HHCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEH
GQLLSYFIPSIIALSILSGIIVGLIATPALAIQCAISVLVSACPCTLGLIIPLAVKTGIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGAEHGVRFKNSRVLQLAEQIDVVIFDLNGTLTTGVPVVNEYAVLNDADLSSEQFLSICN
CCHHCCCEECCHHHHHHHHHCCEEEEECCCCEECCCCCCCCEEEECCCCCCHHHHHHHHH
VLEEQSKHPFGKAIQSFTQGINKQKFNIANLDHSNHSGISAEINGIQYTIGSKTLMQEIG
HHHHHCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEECCEEEECCHHHHHHHHC
ISTSSLENQMNLVAGDSLVFLARNKQLLGYLVITDPLRKDAKQTVDALIKMGKEVHLCTG
CCHHHHHHHHHEEECCCEEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHCCCEEEEECC
ADEKTAYRYAQALGIKKVHANCVATTINTEDRSKPVYIKSLQNQGLKVAMIGDAANDANA
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCCCC
LAASDFGIAVLSQDSDEITQQHASAIIQSGTILPIANAFAISKQTVNNINQNLLISLGYN
EEECCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCC
LTTVLIAGGLLVTLGFVLNPAVGVALMVTQACFVLLNVYRFKEQPLQHLQDKVQEKPEPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSSYEAMKKHSPNFHTAPEINHNSVIQSGKQTINKNKSPSFWSDYFPELFEEEKDTGTEH
CCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHH
LMNNKIG
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8370468 [H]