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The map label for this gene is ykgC [H]

Identifier: 148358455

GI number: 148358455

Start: 342584

End: 343978

Strand: Reverse

Name: ykgC [H]

Synonym: LPC_0321

Alternate gene names: 148358455

Gene position: 343978-342584 (Counterclockwise)

Preceding gene: 148358456

Following gene: 148358454

Centisome position: 9.62

GC content: 44.23

Gene sequence:

>1395_bases
ATGGTTTTAAAGTTTGATACCATCATATTAGGTGGGGGCAAAGGTGGGAAGACTCTTGCAATGGATTTGGCTAAAAGCGG
CCAGAAAATCGCGATGGTTGAAAACAATCAGATCGGCGGGACTTGTATCAATGTGGCATGCATACCTACGAAAACGCTTG
TGCAGTCAGCAAAAGTGGCGCATTACTGCCGTAAAGCAAAAGACTATGGTTTAAATACTACATTGCACCCAATTGATTTT
AAAGCAATTCGAGCACGTAAAGACGCTGTGGTGAATGGGATGCGTGAAGCGAATTTAAAACAATTTTTAGATTCGGGCAT
GGATCTCATGTTAGGACATGGTCATTTTATTGGACCAAAAATGATTGAAGTTACCCTATCCTCACCACGTGACAATCAAA
AAACACTGCACATCACAGCTGATAAAATTATTATTAATACAGGCGCCCTGCCTTACACTCCCCCCATTGCGGGGCTTGAT
AAAGTCAATTATTTTACCAATGACAGTTTAATGAACACCGATTCGGTACCCCAACATTTATTGATCATCGGCGGCGGTTA
TATTGGCTTGGAATTTGCACAAATGTTTCGCCGGTTTGGCGCTGAAGTCACCGTCATCGAAGCCAGCAGCGAATTTCTTG
GCCGGGAAGACAAGGACATTGCTGAACAGGTTTTTCAAACCTTATCCAACGAAGGCATTCAATTTGCTGTCGATACAAAG
ATTAATGCCATTCGCCAAGAGCAAACTGAAGTGATTATCGAAGCGAATCGACAAGGCCAATCAGAAATTATTCGTGGCAC
AGCTGTCCTGGTTGCAGTAGGACGTATTGCCAATACAGCAGGATTGCATTTGGATAAAACTGGCGTTGAACTTGATGAGC
GTGGATTCATCAAAGTCAATGAGTTTCTCGAAACGACAGCGGCAGGAATTTGGGCATTGGGCGATGTCAAGGGAGGGGCA
CAGTTTACCCACCTGTCTCTTGATGACTATCGTCTGGTGAAACATAATTTACAAAACCCCCAGAAAAAGCTTTCTTCCCA
AAACAGGCTTATTCCTTACACAGTGTTTCTCGACCCGGAATTAGCACGCATTGGACTTACTGAAGCTCAAGCCAGATCCC
AAGGCCGCCCAATTAAAATCGCCAAAATTCCGGCAGCTGCGATTCCTCGCGCCAAAACCCAAGGGGAAACAACGGGTGTT
TTAAAAGCAGTCATTGACGCTGAAACCGATTTGATTTTGGGCGTTTCTATTTTCTGTGCGGAGGCAGGGGAAATATTAGG
GGTCATCCAATTAGCAATGGAGTTGCGCATACCTTATCAAAAATTGCGCGATATGATGTTCGCTCACCCTACTCTAGTGG
AAGGCATCAATCTGTGGTTTGCGCAAATAATTTGA

Upstream 100 bases:

>100_bases
ATTTTTTATCGCCTTGCGTGAGCTTTCCTCTTTAATTCAAGTATTGTAAATAAGGATCATCATCAAGTGGATAAAACATT
GAAATTTTGGGGAGAATGGA

Downstream 100 bases:

>100_bases
ATTGATGTAAACCATACTCGCCATATTACATGCTACAAGGCAAGTGGTTAATAGAGGCATTTTACTTCACTTCTTCAATA
AATCCTGTGTATAGGCAGTA

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MVLKFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLHPIDF
KAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLD
KVNYFTNDSLMNTDSVPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRPIKIAKIPAAAIPRAKTQGETTGV
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRIPYQKLRDMMFAHPTLVEGINLWFAQII

Sequences:

>Translated_464_residues
MVLKFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLHPIDF
KAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLD
KVNYFTNDSLMNTDSVPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRPIKIAKIPAAAIPRAKTQGETTGV
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRIPYQKLRDMMFAHPTLVEGINLWFAQII
>Mature_464_residues
MVLKFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVAHYCRKAKDYGLNTTLHPIDF
KAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPKMIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLD
KVNYFTNDSLMNTDSVPQHLLIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVNEFLETTAAGIWALGDVKGGA
QFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPELARIGLTEAQARSQGRPIKIAKIPAAAIPRAKTQGETTGV
LKAVIDAETDLILGVSIFCAEAGEILGVIQLAMELRIPYQKLRDMMFAHPTLVEGINLWFAQII

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.0672451193059, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=26.4957264957265, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=25.1626898047722, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=26.0869565217391, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=26.0869565217391, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=26.0869565217391, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI148277065, Length=437, Percent_Identity=26.0869565217391, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=26.0869565217391, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=26.530612244898, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI291045268, Length=437, Percent_Identity=24.9427917620137, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI65787454, Length=187, Percent_Identity=24.5989304812834, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21389617, Length=187, Percent_Identity=24.5989304812834, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI226437568, Length=187, Percent_Identity=24.5989304812834, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=39.8706896551724, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=30.3493449781659, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=27.1929824561404, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1789915, Length=437, Percent_Identity=27.2311212814645, Blast_Score=161, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=30.3030303030303, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=28.3018867924528, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=352, Percent_Identity=26.4204545454545, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=352, Percent_Identity=26.4204545454545, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=26.25, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17559934, Length=243, Percent_Identity=28.3950617283951, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=31.063829787234, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=25.2676659528908, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=23.5042735042735, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=29.7592997811816, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=27.2349272349272, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=27.027027027027, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=27.2349272349272, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=24.2299794661191, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 50685; Mature: 50685

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVA
CEEEEEEEEEECCCCCCEEEEEHHHCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHH
HYCRKAKDYGLNTTLHPIDFKAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCCCE
MIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLDKVNYFTNDSLMNTDSVPQHL
EEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEE
LIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
EEEECCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECH
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVN
HHHHHHCCCEEEEEECCCCHHHHHHHHEEEEEHHHHCCCCCCEEECCCCCCCCCCCEEHH
EFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPE
HHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHCCCCCEEEEEEEECCC
LARIGLTEAQARSQGRPIKIAKIPAAAIPRAKTQGETTGVLKAVIDAETDLILGVSIFCA
HHHCCCCHHHHHCCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
EAGEILGVIQLAMELRIPYQKLRDMMFAHPTLVEGINLWFAQII
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLKFDTIILGGGKGGKTLAMDLAKSGQKIAMVENNQIGGTCINVACIPTKTLVQSAKVA
CEEEEEEEEEECCCCCCEEEEEHHHCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHH
HYCRKAKDYGLNTTLHPIDFKAIRARKDAVVNGMREANLKQFLDSGMDLMLGHGHFIGPK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCCCE
MIEVTLSSPRDNQKTLHITADKIIINTGALPYTPPIAGLDKVNYFTNDSLMNTDSVPQHL
EEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEE
LIIGGGYIGLEFAQMFRRFGAEVTVIEASSEFLGREDKDIAEQVFQTLSNEGIQFAVDTK
EEEECCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECH
INAIRQEQTEVIIEANRQGQSEIIRGTAVLVAVGRIANTAGLHLDKTGVELDERGFIKVN
HHHHHHCCCEEEEEECCCCHHHHHHHHEEEEEHHHHCCCCCCEEECCCCCCCCCCCEEHH
EFLETTAAGIWALGDVKGGAQFTHLSLDDYRLVKHNLQNPQKKLSSQNRLIPYTVFLDPE
HHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHCCCCCEEEEEEEECCC
LARIGLTEAQARSQGRPIKIAKIPAAAIPRAKTQGETTGVLKAVIDAETDLILGVSIFCA
HHHCCCCHHHHHCCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
EAGEILGVIQLAMELRIPYQKLRDMMFAHPTLVEGINLWFAQII
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]